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modification
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PR:000001759 |
nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form
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NFKB1/iso:2/PhosRes+
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"A nuclear factor NF-kappa-B p105 subunit isoform 2 that includes at least one phosphorylated residue." [PRO:JAN]
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modification
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PR:000001760 |
nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 1
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NFKB1/iso:2/Phos:1
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"A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form in which the phosphorylation occurs by the action of GSK-3 beta which forms an in vivo complex with and specifically phosphorylates nuclear factor NF-kappa-B p105 subunit at two Ser residues in the C-terminal region contiguos to the Death domain. Phosphorylation by GSK-3 stabilizes the protein. Example: UniProtKB:P19838-1, Ser-903/Ser-907, MOD:00046." [PMID:12871932, PRO:JAN]
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modification
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PR:000001762 |
nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 2
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NFKB1/iso:2/Phos:2
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"A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form that has been pre-phosphorylated by GSK-3 beta (PR:000001760) followed by phosphorylation of the two Ser residues within the conserved motif DSGVETS in the PEST region. Phosphorylation occurs after the stimulation of cells with proinflammatory cytokines, such as tumor necrosis factor or interleukin-1. This phosphorylation results in accelerated nuclear factor NF-kappa-B p105 degradation. Example: UniProtKB:P19838-1, Ser-903/Ser-907/Ser-927/Ser-932, MOD:00046." [PMID:12482991, PMID:12871932]
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