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Protein Ontology report - nuclear factor NF-kappa-B p105 subunit isoform 2
PR:000001758 - http://purl.obolibrary.org/obo/PR_000001758
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001758   
  PRO namenuclear factor NF-kappa-B p105 subunit isoform 2 
  Synonyms
PRO-Short-label: EXACT:NFKB1/iso:2
  Definition"A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-1 or a 1:1 ortholog thereof." [PMID:1992489] 
  PRO Categorysequence 
  ParentPR:000001754 nuclear factor NF-kappa-B p105 subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 1                                        
         Modification3                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000001758
nuclear factor NF-kappa-B p105 subunit isoform 2
NFKB1/iso:2
"A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-1 or a 1:1 ortholog thereof." [PMID:1992489]

organism-sequence


PR:P19838-1
nuclear factor NF-kappa-B p105 subunit isoform 1 (human)
hNFKB1/iso:1
"A nuclear factor NF-kappa-B p105 subunit isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19838]

modification


PR:000001759
nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form
NFKB1/iso:2/PhosRes+
"A nuclear factor NF-kappa-B p105 subunit isoform 2 that includes at least one phosphorylated residue." [PRO:JAN]

modification


PR:000001760
nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 1
NFKB1/iso:2/Phos:1
"A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form in which the phosphorylation occurs by the action of GSK-3 beta which forms an in vivo complex with and specifically phosphorylates nuclear factor NF-kappa-B p105 subunit at two Ser residues in the C-terminal region contiguos to the Death domain. Phosphorylation by GSK-3 stabilizes the protein. Example: UniProtKB:P19838-1, Ser-903/Ser-907, MOD:00046." [PMID:12871932, PRO:JAN]

modification


PR:000001762
nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 2
NFKB1/iso:2/Phos:2
"A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form that has been pre-phosphorylated by GSK-3 beta (PR:000001760) followed by phosphorylation of the two Ser residues within the conserved motif DSGVETS in the PEST region. Phosphorylation occurs after the stimulation of cells with proinflammatory cytokines, such as tumor necrosis factor or interleukin-1. This phosphorylation results in accelerated nuclear factor NF-kappa-B p105 degradation. Example: UniProtKB:P19838-1, Ser-903/Ser-907/Ser-927/Ser-932, MOD:00046." [PMID:12482991, PMID:12871932]