back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - TIR domain-containing adapter molecule 2
PR:000001750 - http://purl.obolibrary.org/obo/PR_000001750
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001750   
  PRO nameTIR domain-containing adapter molecule 2 
  Synonyms
PRO-Short-label: EXACT:TICAM2
Gene-based: RELATED:TIRAP3 | TIRP | TRAM
Other: EXACT:putative NF-kappa-B-activating protein 502 | TICAM-2 | Toll-like receptor adaptor protein 3 | Toll/interleukin-1 receptor domain-containing protein | TRIF-related adapter molecule
  Definition"A protein that is a translation product of the human TICAM2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF037745
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001750
TIR domain-containing adapter molecule 2
TICAM2
"A protein that is a translation product of the human TICAM2 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:Q86XR7
TIR domain-containing adapter molecule 2 (human)
hTICAM2
"A TIR domain-containing adapter molecule 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q86XR7]

organism-sequence


PR:Q86XR7-1
TIR domain-containing adapter molecule 2 isoform 1 (human)
hTICAM2/iso:1
"A TIR domain-containing adapter molecule 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000027201
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)
hTICAM2/iso:1/InitMet-/Myr:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at position 2 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068." [PRO:CNA]

organism-modification


PR:000040891
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
hTICAM2/iso:1/InitMet-/MyrPhos:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at Gly-2 and phosphorylated at Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046." [PMID:16757566, PRO:DAN]

Yes
organism-sequence


PR:Q86XR7-2
TIR domain-containing adapter molecule 2 isoform h2 (human)
hTICAM2/iso:h2
"A TIR domain-containing adapter molecule 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86XR7-2." [PRO:DNx, UniProtKB:Q86XR7]

organism-modification


PR:000063665
TIR domain-containing adapter molecule 2, initiator methionine removed myristoylated and phosphorylated 1 (human)
hTICAM2/InitMet-/MyrPhos:1
"A TIR domain-containing adapter molecule 2 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. Example: UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046." [PRO:DNx, Reactome:R-HSA-166160, Reactome:R-HSA-2201336, Reactome:R-HSA-6804964]

organism-gene


PR:Q8BJQ4
TIR domain-containing adapter molecule 2 (mouse)
mTICAM2
"A TIR domain-containing adapter molecule 2 that is encoded in the genome of mouse." [OMA:Q8BJQ4, PRO:CNA]

Yes
organism-sequence


PR:Q8BJQ4-1
TIR domain-containing adapter molecule 2 isoform 1 (mouse)
mTICAM2/iso:1
"A TIR domain-containing adapter molecule 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

sequence


PR:000027197
TIR domain-containing adapter molecule 2 isoform 1
TICAM2/iso:1
"A TIR domain-containing adapter molecule 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86XR7-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:Q86XR7-1
TIR domain-containing adapter molecule 2 isoform 1 (human)
hTICAM2/iso:1
"A TIR domain-containing adapter molecule 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000027201
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)
hTICAM2/iso:1/InitMet-/Myr:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at position 2 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068." [PRO:CNA]

organism-modification


PR:000040891
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
hTICAM2/iso:1/InitMet-/MyrPhos:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at Gly-2 and phosphorylated at Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046." [PMID:16757566, PRO:DAN]

Yes
organism-sequence


PR:Q8BJQ4-1
TIR domain-containing adapter molecule 2 isoform 1 (mouse)
mTICAM2/iso:1
"A TIR domain-containing adapter molecule 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000027199
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed form
TICAM2/iso:1/InitMet-
"A TIR domain-containing adapter molecule 2 isoform 1 that has had the initiator methionine removed. Example: UniProtKB:Q86XR7-1, 2-235." [PRO:CNA]

modification


PR:000027200
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form
TICAM2/iso:1/InitMet-/MyrRes+
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed form that has been N-terminally myristoylated. Example: UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068." [PMID:16603631, PRO:CNA]

organism-modification


PR:000027201
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)
hTICAM2/iso:1/InitMet-/Myr:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at position 2 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068." [PRO:CNA]

organism-modification


PR:000040891
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
hTICAM2/iso:1/InitMet-/MyrPhos:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at Gly-2 and phosphorylated at Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046." [PMID:16757566, PRO:DAN]

Yes
Back to top
TICAM2 forms found in complexes   

TICAM2 Component
 Complexes
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028678 ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:Q8BJQ4 mTICAM2 PR:000027204 ticam2:activated TLR4 complex (mouse)
PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)
PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)