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Protein Ontology report - proteinase-activated receptor 1
PR:000001661 - http://purl.obolibrary.org/obo/PR_000001661
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001661   
  PRO nameproteinase-activated receptor 1 
  Synonyms
PRO-Short-label: EXACT:F2R
Gene-based: RELATED:CF2R | PAR1 | TR
Other: EXACT:coagulation factor II receptor | PAR-1 | thrombin receptor
  Definition"A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PMID:1672265, PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001550 proteinase-activated receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:347
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001661

proteinase-activated receptor 1

F2R


"A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PMID:1672265, PRO:WCB]


organism-gene



PR:P25116

proteinase-activated receptor 1 (human)

hF2R


"A proteinase-activated receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25116]


organism-modification



PR:000060708

proteinase-activated receptor 1, signal peptide removed form (human)

hF2R/SigPep-


"A proteinase-activated receptor 1 (human) that has had the signal peptide removed. UniProtKB:P25116, 22-425." [PRO:DNx, Reactome:R-HSA-9708861]


organism-modification



PR:000073448

proteinase-activated receptor 1 deaminated 1 (human)

hF2R/Deam:1


"A proteinase-activated receptor 1 (human) that has been deaminated on the residue at the position equivalent to Asn-75 of the amino acid sequence represented by UniProtKB:P25116. UniProtKB:P25116, Asn-75, MOD:00684." [IEDB_epitope:1999361, PRO:DNx]


organism-gene



PR:P26824

proteinase-activated receptor 1 (rat)

rF2R


"A proteinase-activated receptor 1 that is encoded in the genome of rat." [OMA:P26824, PRO:DNx]


organism-gene



PR:P30558

proteinase-activated receptor 1 (mouse)

mF2R


"A proteinase-activated receptor 1 that is encoded in the genome of mouse." [OMA:P30558, PRO:DNx]


modification



PR:000018513

proteinase-activated receptor 1 proteolytic cleavage product

F2R/ClvPrd


"A proteinase-activated receptor 1 that has been processed by proteolytic cleavage." [PRO:DNx]