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family
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PR:000001550 |
proteinase-activated receptor
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fam:PAR
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"A rhodopsin-like G-protein coupled receptor that is a translation product of the human F2R, or F2RL1 to F2RL3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds trypsin-related proteinases. The proteinase cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PRO:WCB, PRO:XQ]
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gene
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PR:000001661 |
proteinase-activated receptor 1
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F2R
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"A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PMID:1672265, PRO:WCB]
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organism-gene
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PR:P25116 |
proteinase-activated receptor 1 (human)
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hF2R
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"A proteinase-activated receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25116]
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organism-modification
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PR:000060708 |
proteinase-activated receptor 1, signal peptide removed form (human)
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hF2R/SigPep-
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"A proteinase-activated receptor 1 (human) that has had the signal peptide removed. UniProtKB:P25116, 22-425." [PRO:DNx, Reactome:R-HSA-9708861]
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organism-modification
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PR:000073448 |
proteinase-activated receptor 1 deaminated 1 (human)
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hF2R/Deam:1
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"A proteinase-activated receptor 1 (human) that has been deaminated on the residue at the position equivalent to Asn-75 of the amino acid sequence represented by UniProtKB:P25116. UniProtKB:P25116, Asn-75, MOD:00684." [IEDB_epitope:1999361, PRO:DNx]
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organism-gene
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PR:P26824 |
proteinase-activated receptor 1 (rat)
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rF2R
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"A proteinase-activated receptor 1 that is encoded in the genome of rat." [OMA:P26824, PRO:DNx]
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organism-gene
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PR:P30558 |
proteinase-activated receptor 1 (mouse)
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mF2R
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"A proteinase-activated receptor 1 that is encoded in the genome of mouse." [OMA:P30558, PRO:DNx]
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modification
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PR:000018513 |
proteinase-activated receptor 1 proteolytic cleavage product
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F2R/ClvPrd
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"A proteinase-activated receptor 1 that has been processed by proteolytic cleavage." [PRO:DNx]
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gene
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PR:000001662 |
proteinase-activated receptor 2
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F2RL1
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"A proteinase-activated receptor that is a translation product of the human F2RL1 gene or a 1:1 ortholog thereof. It is activated by trypsin and trypsin-like proteinases, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity." [PMID:7556175, PRO:WCB]
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organism-gene
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PR:P55085 |
proteinase-activated receptor 2 (human)
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hF2RL1
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"A proteinase-activated receptor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P55085]
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organism-gene
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PR:P55086 |
proteinase-activated receptor 2 (mouse)
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mF2RL1
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"A proteinase-activated receptor 2 that is encoded in the genome of mouse." [OMA:P55086, PRO:DNx]
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organism-gene
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PR:Q63645 |
proteinase-activated receptor 2 (rat)
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rF2RL1
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"A proteinase-activated receptor 2 that is encoded in the genome of rat." [OMA:Q63645, PRO:DNx]
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gene
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PR:000001663 |
proteinase-activated receptor 3
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F2RL2
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"A proteinase-activated receptor that is a translation product of the human F2RL2 gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity." [PMID:15582715, PRO:WCB]
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organism-gene
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PR:O00254 |
proteinase-activated receptor 3 (human)
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hF2RL2
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"A proteinase-activated receptor 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O00254]
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organism-sequence
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PR:O00254-1 |
proteinase-activated receptor 3 isoform h1 (human)
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hF2RL2/iso:h1
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"A proteinase-activated receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00254-1." [PRO:DNx, UniProtKB:O00254]
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organism-sequence
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PR:O00254-2 |
proteinase-activated receptor 3 isoform h2 (human)
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hF2RL2/iso:h2
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"A proteinase-activated receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00254-2." [PRO:DNx, UniProtKB:O00254]
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organism-modification
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PR:000047350 |
proteinase-activated receptor 3, signal peptide removed form (human)
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hF2RL2/SigPep-
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"A proteinase-activated receptor 3 (human) that has had the signal peptide removed. UniProtKB:O00254, 22-374." [PRO:DNx, Reactome:R-HSA-61313]
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organism-modification
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PR:000065094 |
proteinase-activated receptor 3, mature form (human)
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hF2RL2/mature
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"A proteinase-activated receptor 3 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:O00254-1, 39-374." [PRO:DNx, Reactome:R-HSA-114532]
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organism-modification
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PR:000065094 |
proteinase-activated receptor 3, mature form (human)
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hF2RL2/mature
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"A proteinase-activated receptor 3 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:O00254-1, 39-374." [PRO:DNx, Reactome:R-HSA-114532]
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organism-gene
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PR:O08675 |
proteinase-activated receptor 3 (mouse)
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mF2RL2
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"A proteinase-activated receptor 3 that is encoded in the genome of mouse." [OMA:O08675, PRO:DNx]
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organism-gene
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PR:Q920E1 |
proteinase-activated receptor 3 (rat)
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rF2RL2
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"A proteinase-activated receptor 3 that is encoded in the genome of rat." [OMA:Q920E1, PRO:DNx]
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gene
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PR:000001664 |
proteinase-activated receptor 4
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F2RL3
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"A proteinase-activated receptor that is a translation product of the human F2RL3 gene or a 1:1 ortholog thereof. It is activated by thrombin and cathepsin G, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity." [PMID:10702240, PMID:9618465, PRO:WCB]
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organism-gene
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PR:O88634 |
proteinase-activated receptor 4 (mouse)
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mF2RL3
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"A proteinase-activated receptor 4 that is encoded in the genome of mouse." [OMA:O88634, PRO:DNx]
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organism-gene
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PR:Q920E0 |
proteinase-activated receptor 4 (rat)
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rF2RL3
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"A proteinase-activated receptor 4 that is encoded in the genome of rat." [OMA:Q920E0, PRO:DNx]
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organism-gene
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PR:Q96RI0 |
proteinase-activated receptor 4 (human)
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hF2RL3
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"A proteinase-activated receptor 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q96RI0]
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organism-modification
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PR:000047351 |
proteinase-activated receptor 4, signal peptide removed form (human)
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hF2RL3/SigPep-
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"A proteinase-activated receptor 4 (human) that has had the signal peptide removed. UniProtKB:Q96RI0, 18-385." [PRO:DNx, Reactome:R-HSA-61315]
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organism-modification
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PR:000084005 |
proteinase-activated receptor 4, mature form (human)
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hF2RL3/mature
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"A proteinase-activated receptor 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:Q96RI0, 48-385." [PRO:DNx, Reactome:R-HSA-114533]
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organism-modification
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PR:000067745 |
proteinase-activated receptor 4 deaminated 1 (human)
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hF2RL3/Deam:1
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"A proteinase-activated receptor 4 (human) that has been deaminated on the residue at the position equivalent to Asn-332 of the amino acid sequence represented by UniProtKB:Q96RI0. UniProtKB:Q96RI0, Asn-332, MOD:00684." [IEDB_epitope:1325665, PRO:DNx]
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organism-modification
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PR:000084005 |
proteinase-activated receptor 4, mature form (human)
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hF2RL3/mature
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"A proteinase-activated receptor 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:Q96RI0, 48-385." [PRO:DNx, Reactome:R-HSA-114533]
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