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Protein Ontology report - free fatty acid receptor
PR:000001452 - http://purl.obolibrary.org/obo/PR_000001452
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001452   
  PRO namefree fatty acid receptor 
  Synonyms
PRO-Short-label: EXACT:fam:FFA_R
  Definition"A rhodopsin-like G-protein coupled receptor that is a translation product of the human FFAR1 to FFAR4, or GPR42 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds free fatty acid." [PMID:15684720, PMID:17052194, PRO:DAN, PRO:WCB, PRO:XQ] 
  CommentNote: In humans there are four tandem genes located downstream of CD22 on chromosome 19. One of these, GPR42P, is a pseudogene formed by recent duplication of FFAR3. A fifth gene, FFAR4, is on a different chromosome. 
  PRO Categoryfamily 
  ParentPR:000001094 rhodopsin-like G-protein coupled receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 10                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF006358;IUPHARfam:24
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001452

free fatty acid receptor

fam:FFA_R


"A rhodopsin-like G-protein coupled receptor that is a translation product of the human FFAR1 to FFAR4, or GPR42 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds free fatty acid." [PMID:15684720, PMID:17052194, PRO:DAN, PRO:WCB, PRO:XQ]


gene



PR:000001582

free fatty acid receptor 1

FFAR1


"A free fatty acid receptor that is a translation product of the human FFAR1 gene or a 1:1 ortholog thereof. Its preferred ligands are medium and long-chain fatty acids. It potentiates fatty acid-stimulated insulin secretion in pancreatic islets." [PMID:17052194, PRO:WCB]


organism-gene



PR:O14842

free fatty acid receptor 1 (human)

hFFAR1


"A free fatty acid receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14842]


organism-sequence



PR:O14842-1

free fatty acid receptor 1 isoform 1 (human)

hFFAR1/iso:1


"A free fatty acid receptor 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-gene



PR:Q76JU9

free fatty acid receptor 1 (mouse)

mFFAR1


"A free fatty acid receptor 1 that is encoded in the genome of mouse." [OMA:Q76JU9, PRO:DNx]


organism-sequence



PR:Q76JU9-1

free fatty acid receptor 1 isoform 1 (mouse)

mFFAR1/iso:1


"A free fatty acid receptor 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q8K3T4

free fatty acid receptor 1 (rat)

rFFAR1


"A free fatty acid receptor 1 that is encoded in the genome of rat." [OMA:Q8K3T4, PRO:DNx]


organism-sequence



PR:Q8K3T4-1

free fatty acid receptor 1 isoform 1 (rat)

rFFAR1/iso:1


"A free fatty acid receptor 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000038011

free fatty acid receptor 1 isoform 1

FFAR1/iso:1


"A free fatty acid receptor 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14842-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O14842-1

free fatty acid receptor 1 isoform 1 (human)

hFFAR1/iso:1


"A free fatty acid receptor 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q76JU9-1

free fatty acid receptor 1 isoform 1 (mouse)

mFFAR1/iso:1


"A free fatty acid receptor 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q8K3T4-1

free fatty acid receptor 1 isoform 1 (rat)

rFFAR1/iso:1


"A free fatty acid receptor 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


gene



PR:000001583

free fatty acid receptor 2

FFAR2


"A free fatty acid receptor that is a translation product of the human FFAR2 gene or a 1:1 ortholog thereof. It mediates stimulation of adipogenesis by short-chain fatty acids." [PMID:17052194, PRO:WCB]


organism-gene



PR:O15552

free fatty acid receptor 2 (human)

hFFAR2


"A free fatty acid receptor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O15552]


organism-sequence



PR:O15552-1

free fatty acid receptor 2 isoform 1 (human)

hFFAR2/iso:1


"A free fatty acid receptor 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-gene



PR:Q76EI6

free fatty acid receptor 2 (rat)

rFFAR2


"A free fatty acid receptor 2 that is encoded in the genome of rat." [OMA:Q76EI6, PRO:DNx]


organism-sequence



PR:Q76EI6-1

free fatty acid receptor 2 isoform 1 (rat)

rFFAR2/iso:1


"A free fatty acid receptor 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q8VCK6

free fatty acid receptor 2 (mouse)

mFFAR2


"A free fatty acid receptor 2 that is encoded in the genome of mouse." [OMA:Q8VCK6, PRO:DNx]


organism-sequence



PR:Q8VCK6-1

free fatty acid receptor 2 isoform 1 (mouse)

mFFAR2/iso:1


"A free fatty acid receptor 2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000038083

free fatty acid receptor 2 isoform 1

FFAR2/iso:1


"A free fatty acid receptor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15552-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O15552-1

free fatty acid receptor 2 isoform 1 (human)

hFFAR2/iso:1


"A free fatty acid receptor 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q76EI6-1

free fatty acid receptor 2 isoform 1 (rat)

rFFAR2/iso:1


"A free fatty acid receptor 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q8VCK6-1

free fatty acid receptor 2 isoform 1 (mouse)

mFFAR2/iso:1


"A free fatty acid receptor 2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000001584

free fatty acid receptor 3

FFAR3


"A free fatty acid receptor that is a translation product of the human FFAR3 gene or a 1:1 ortholog thereof. It mediates stimulation of leptin release by short-chain fatty acids." [PMID:17052194, PRO:WCB]


organism-gene



PR:B2GV46

free fatty acid receptor 3 (rat)

rFFAR3


"A free fatty acid receptor 3 that is encoded in the genome of rat." [PRO:WCB]


organism-gene



PR:O14843

free fatty acid receptor 3 (human)

hFFAR3


"A free fatty acid receptor 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14843]


organism-gene



PR:Q3UFD7

free fatty acid receptor 3 (mouse)

mFFAR3


"A free fatty acid receptor 3 that is encoded in the genome of mouse." [PRO:DAN]


gene



PR:000032626

G-protein coupled receptor 42

GPR42


"A free fatty acid receptor that is a translation product of the human GPR42 gene or a 1:1 ortholog thereof." [PRO:DAN]


organism-gene



PR:O15529

G-protein coupled receptor 42 (human)

hGPR42


"A G-protein coupled receptor 42 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15529]