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Protein Ontology report - membrane cofactor protein
PR:000001401 - http://purl.obolibrary.org/obo/PR_000001401
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001401   
  PRO namemembrane cofactor protein 
  Synonyms
PRO-Short-label: EXACT:CD46
Gene-based: RELATED:MCP | MIC10
Other: EXACT:TLX | trophoblast leukocyte common antigen
  Definition"A protein that is a translation product of the human CD46 gene or a 1:1 ortholog thereof. This protein act as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue." [PRO:JAN, UniProtKB:P15529
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 18                                        
         Modification1                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037971
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001401

membrane cofactor protein

CD46


"A protein that is a translation product of the human CD46 gene or a 1:1 ortholog thereof. This protein act as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue." [PRO:JAN, UniProtKB:P15529]


organism-gene



PR:O88174

membrane cofactor protein (mouse)

mCD46


"A membrane cofactor protein that is encoded in the genome of mouse." [OMA:O88174, PRO:DNx]


organism-sequence



PR:O88174-1

membrane cofactor protein isoform m1 (mouse)

mCD46/iso:m1


"A membrane cofactor protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88174-1." [PRO:DNx, UniProtKB:O88174]


organism-sequence



PR:O88174-2

membrane cofactor protein isoform m2 (mouse)

mCD46/iso:m2


"A membrane cofactor protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88174-2." [PRO:DNx, UniProtKB:O88174]


organism-gene



PR:P15529

membrane cofactor protein (human)

hCD46


"A membrane cofactor protein that is encoded in the genome of human." [PRO:JAN, UniProtKB:P15529]


organism-sequence



PR:P15529-1

membrane cofactor protein isoform A (human)

hCD46/iso:A


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-1." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-10

membrane cofactor protein isoform h2 (human)

hCD46/iso:h2


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-10." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-11

membrane cofactor protein isoform C (human)

hCD46/iso:C


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-11." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-12

membrane cofactor protein isoform E (human)

hCD46/iso:E


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-12." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-13

membrane cofactor protein isoform G (human)

hCD46/iso:G


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-13." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-14

membrane cofactor protein isoform I (human)

hCD46/iso:I


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-14." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-15

membrane cofactor protein isoform K (human)

hCD46/iso:K


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-15." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-16

membrane cofactor protein isoform h3 (human)

hCD46/iso:h3


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-16." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-2

membrane cofactor protein isoform B (human)

hCD46/iso:B


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-2." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-3

membrane cofactor protein isoform D (human)

hCD46/iso:D


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-3." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-4

membrane cofactor protein isoform F (human)

hCD46/iso:F


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-4." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-5

membrane cofactor protein isoform H (human)

hCD46/iso:H


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-5." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-6

membrane cofactor protein isoform J (human)

hCD46/iso:J


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-6." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-7

membrane cofactor protein isoform L (human)

hCD46/iso:L


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-7." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-8

membrane cofactor protein isoform M (human)

hCD46/iso:M


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-8." [PRO:DNx, UniProtKB:P15529]


organism-sequence



PR:P15529-9

membrane cofactor protein isoform N (human)

hCD46/iso:N


"A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-9." [PRO:DNx, UniProtKB:P15529]


organism-modification



PR:000046642

membrane cofactor protein, signal peptide removed form (human)

hCD46/SigPep-


"A membrane cofactor protein (human) that has had the signal peptide removed. UniProtKB:P15529, 35-392." [PRO:DNx, Reactome:R-HSA-977362]


organism-modification



PR:000068122

membrane cofactor protein methylated 1 (human)

hCD46/Me:1


"A membrane cofactor protein (human) that has been methylated on the residue at the position equivalent to Cys-256 of the amino acid sequence represented by UniProtKB:P15529-1. Example: UniProtKB:P15529-1, Cys-256, MOD:00660." [IEDB_epitope:1058386, PRO:DNx]


organism-modification



PR:000074235

membrane cofactor protein cysteinylated 1 (human)

hCD46/Cyst:1


"A membrane cofactor protein (human) that has been cysteinylated on the residue at the position equivalent to Cys-162 of the amino acid sequence represented by UniProtKB:P15529-1. Example: UniProtKB:P15529-1, Cys-162, MOD:00765." [IEDB_epitope:2123572, PRO:DNx]


organism-modification



PR:000080580

membrane cofactor protein cysteinylated 2 (human)

hCD46/Cyst:2


"A membrane cofactor protein (human) that has been cysteinylated on the residue at the position equivalent to Cys-256 of the amino acid sequence represented by UniProtKB:P15529-1. Example: UniProtKB:P15529-1, Cys-256, MOD:00765." [IEDB_epitope:2120204, IEDB_epitope:2120492, IEDB_epitope:2120493, IEDB_epitope:2122624, PRO:DNx]


modification



PR:000018465

membrane cofactor protein, signal peptide removed form

CD46/SigPep-


"A membrane cofactor protein that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000046642

membrane cofactor protein, signal peptide removed form (human)

hCD46/SigPep-


"A membrane cofactor protein (human) that has had the signal peptide removed. UniProtKB:P15529, 35-392." [PRO:DNx, Reactome:R-HSA-977362]