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Protein Ontology report - interleukin-6 receptor subunit alpha
PR:000001394 - http://purl.obolibrary.org/obo/PR_000001394
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001394   
  PRO nameinterleukin-6 receptor subunit alpha 
  Synonyms
PRO-Short-label: EXACT:IL6R
Gene-based: RELATED:Il6ra
Other: EXACT:CD126 | gp80 | IL-6 receptor subunit alpha | IL-6R 1 | IL-6R subunit alpha | IL-6R-alpha | IL-6RA | membrane glycoprotein 80
  Definition"A protein that is a translation product of the human IL6R gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence3                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1708
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001394

interleukin-6 receptor subunit alpha

IL6R


"A protein that is a translation product of the human IL6R gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P08887

interleukin-6 receptor subunit alpha (human)

hIL6R


"An interleukin-6 receptor subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08887]


organism-sequence



PR:P08887-1

interleukin-6 receptor subunit alpha isoform 1 (human)

hIL6R/iso:1


"An interleukin-6 receptor subunit alpha isoform 2 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P08887-2

interleukin-6 receptor subunit alpha isoform 2 (human)

hIL6R/iso:2


"An interleukin-6 receptor subunit alpha isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000061562

interleukin-6 receptor subunit alpha isoform 2, signal peptide removed form (human)

hIL6R/iso:2/SigPep-


"An interleukin-6 receptor subunit alpha isoform 2 (human) that has had the signal peptide removed. UniProtKB:P08887-2, 20-365." [PRO:DNx, Reactome:R-HSA-1067661]


organism-modification



PR:000048029

interleukin-6 receptor subunit alpha, signal peptide removed form (human)

hIL6R/SigPep-


"An interleukin-6 receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:P08887, 20-468." [PRO:DNx, Reactome:R-HSA-197824]


organism-modification



PR:000061562

interleukin-6 receptor subunit alpha isoform 2, signal peptide removed form (human)

hIL6R/iso:2/SigPep-


"An interleukin-6 receptor subunit alpha isoform 2 (human) that has had the signal peptide removed. UniProtKB:P08887-2, 20-365." [PRO:DNx, Reactome:R-HSA-1067661]


organism-modification



PR:000054602

interleukin-6 receptor subunit alpha O-glycosylated 1 (human)

hIL6R/OGlyco:1


"An interleukin-6 receptor subunit alpha (human) that has been O-glycosylated at the residue equivalent to Thr-329 of the amino acid sequence represented by UniProtKB:P08887-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08887-1, Thr-329, MOD:00005~GNO:G43417UB." [GlyGen:P08887-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000054603

interleukin-6 receptor subunit alpha O-glycosylated 2 (human)

hIL6R/OGlyco:2


"An interleukin-6 receptor subunit alpha (human) that has been O-glycosylated at the residue equivalent to Thr-335 of the amino acid sequence represented by UniProtKB:P08887-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P08887-1, Thr-335, MOD:00005~GNO:G53434XO." [GlyGen:P08887-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P22272

interleukin-6 receptor subunit alpha (mouse)

mIL6R


"An interleukin-6 receptor subunit alpha that is encoded in the genome of mouse." [OMA:P22272, PRO:DNx]


organism-sequence



PR:P22272-1

interleukin-6 receptor subunit alpha isoform 1 (mouse)

mIL6R/iso:1


"An interleukin-6 receptor subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-modification



PR:000044514

interleukin-6 receptor subunit alpha isoform 1 soluble form (mouse)

mIL6R/iso:1/Clv:soluble


"An interleukin-6 receptor subunit alpha isoform 1 soluble form in mouse." [PRO:DNx]

Yes

organism-gene



PR:P22273

interleukin-6 receptor subunit alpha (rat)

rIL6R


"An interleukin-6 receptor subunit alpha that is encoded in the genome of rat." [OMA:P22273, PRO:DNx]


organism-gene



PR:Q5DWQ5

interleukin-6 receptor alpha chain (chicken)

chick-IL6R


"An interleukin-6 receptor subunit alpha that is encoded in the genome of chicken." [PANTHER:PTHR23036:SF27, PRO:DNx]


sequence



PR:000001794

interleukin-6 receptor subunit alpha isoform 1

IL6R/iso:1


"An interleukin-6 receptor subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22272-1 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:P22272-1

interleukin-6 receptor subunit alpha isoform 1 (mouse)

mIL6R/iso:1


"An interleukin-6 receptor subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-modification



PR:000044514

interleukin-6 receptor subunit alpha isoform 1 soluble form (mouse)

mIL6R/iso:1/Clv:soluble


"An interleukin-6 receptor subunit alpha isoform 1 soluble form in mouse." [PRO:DNx]

Yes

modification



PR:000001798

interleukin-6 receptor subunit alpha isoform 1 soluble form

IL6R/iso:1/Clv:soluble


"An interleukin-6 receptor subunit alpha isoform 1 that has been post-translationally cleaved to release the extracellular domain into the extracellular space." [PMID:8477802, PRO:HJD]


organism-modification



PR:000044514

interleukin-6 receptor subunit alpha isoform 1 soluble form (mouse)

mIL6R/iso:1/Clv:soluble


"An interleukin-6 receptor subunit alpha isoform 1 soluble form in mouse." [PRO:DNx]

Yes

modification



PR:000026630

interleukin-6 receptor subunit alpha isoform 1, signal peptide removed form

IL6R/iso:1/SigPep-


"An interleukin-6 receptor subunit alpha isoform 1 that has had the signal peptide removed." [PRO:DNx]


sequence



PR:000001795

interleukin-6 receptor subunit alpha isoform 2

IL6R/iso:2


"An interleukin-6 receptor subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08887-1 or a 1:1 ortholog thereof." [PRO:HJD]


organism-sequence



PR:P08887-1

interleukin-6 receptor subunit alpha isoform 1 (human)

hIL6R/iso:1


"An interleukin-6 receptor subunit alpha isoform 2 that is encoded in the genome of human." [PRO:HJD]


modification



PR:000026634

interleukin-6 receptor subunit alpha isoform 2, signal peptide removed form

IL6R/iso:2/SigPep-


"An interleukin-6 receptor subunit alpha isoform 2 that has had the signal peptide removed." [PRO:DNx]


sequence



PR:000001796

interleukin-6 receptor subunit alpha isoform 3

IL6R/iso:3


"An interleukin-6 receptor subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08887-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P08887-2

interleukin-6 receptor subunit alpha isoform 2 (human)

hIL6R/iso:2


"An interleukin-6 receptor subunit alpha isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000061562

interleukin-6 receptor subunit alpha isoform 2, signal peptide removed form (human)

hIL6R/iso:2/SigPep-


"An interleukin-6 receptor subunit alpha isoform 2 (human) that has had the signal peptide removed. UniProtKB:P08887-2, 20-365." [PRO:DNx, Reactome:R-HSA-1067661]


modification



PR:000018458

interleukin-6 receptor subunit alpha, signal peptide removed form

IL6R/SigPep-


"An interleukin-6 receptor subunit alpha that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026630

interleukin-6 receptor subunit alpha isoform 1, signal peptide removed form

IL6R/iso:1/SigPep-


"An interleukin-6 receptor subunit alpha isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026634

interleukin-6 receptor subunit alpha isoform 2, signal peptide removed form

IL6R/iso:2/SigPep-


"An interleukin-6 receptor subunit alpha isoform 2 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000048029

interleukin-6 receptor subunit alpha, signal peptide removed form (human)

hIL6R/SigPep-


"An interleukin-6 receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:P08887, 20-468." [PRO:DNx, Reactome:R-HSA-197824]


organism-modification



PR:000061562

interleukin-6 receptor subunit alpha isoform 2, signal peptide removed form (human)

hIL6R/iso:2/SigPep-


"An interleukin-6 receptor subunit alpha isoform 2 (human) that has had the signal peptide removed. UniProtKB:P08887-2, 20-365." [PRO:DNx, Reactome:R-HSA-1067661]


modification



PR:000025429

interleukin-6 receptor subunit alpha proteolytic cleavage product

IL6R/ClvPrd


"An interleukin-6 receptor subunit alpha that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000001798

interleukin-6 receptor subunit alpha isoform 1 soluble form

IL6R/iso:1/Clv:soluble


"An interleukin-6 receptor subunit alpha isoform 1 that has been post-translationally cleaved to release the extracellular domain into the extracellular space." [PMID:8477802, PRO:HJD]


organism-modification



PR:000044514

interleukin-6 receptor subunit alpha isoform 1 soluble form (mouse)

mIL6R/iso:1/Clv:soluble


"An interleukin-6 receptor subunit alpha isoform 1 soluble form in mouse." [PRO:DNx]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044514 mIL6R/iso:1/Clv:soluble acts_upstream_of_or_withinGO:0070102 interleukin-6-mediated signaling pathway PMID:8477802
enablesGO:0004915 interleukin-6 receptor activity PMID:8477802
GO:0019981 interleukin-6 binding PMID:8477802
located_inGO:0005615 extracellular space PMID:8477802
PR:P22272-1 mIL6R/iso:1 acts_upstream_of_or_withinGO:0070102 interleukin-6-mediated signaling pathway MGI_ref:50330; PMID:1312474
enablesGO:0004915 interleukin-6 receptor activity MGI_ref:50330; PMID:1312474
GO:0019981 interleukin-6 binding MGI_ref:50330; PMID:1312474
located_inGO:0009986 cell surface MGI_ref:50330; PMID:1312474