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Protein Ontology report - interferon lambda
PR:000001362 - http://purl.obolibrary.org/obo/PR_000001362
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001362   
  PRO nameinterferon lambda 
  Synonyms
Other: RELATED:interferon type III | type III interferon
  Definition"A type III interferon that is distantly related to type I interferons (IFNs) and the interleukin-10 family. It comprises the translation product of the IL28A, IL28B and IL29 genes. Generally induced by viral infection and exert their antiviral and immunomodulatory activities through a unique receptor complex composed of IFN-lambdaR1 and interleukin 10 receptor 2." [PMID:16618774
  CommentNote: Some references consider 'lambda' and 'type III' to be synonyms. This is likely because lambda is the only type III interferon identified. However, the classification criteria for each nomenclature system differ. 
  PRO Categoryfamily 
  ParentPR:000028205 type III interferon
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001362

interferon lambda

IFNGR1


"A type III interferon that is distantly related to type I interferons (IFNs) and the interleukin-10 family. It comprises the translation product of the IL28A, IL28B and IL29 genes. Generally induced by viral infection and exert their antiviral and immunomodulatory activities through a unique receptor complex composed of IFN-lambdaR1 and interleukin 10 receptor 2." [PMID:16618774]


gene



PR:000001469

interleukin-28A

IFNL2


"An interferon lambda that is a translation product of the human IFNL2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8IZJ0

interferon lambda-2 (human)

hIFNL2


"An interleukin-28A that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8IZJ0]


organism-modification



PR:000047967

interferon lambda-2, signal peptide removed form (human)

hIFNL2/SigPep-


"An interferon lambda-2 (human) that has had the signal peptide removed. UniProtKB:Q8IZJ0, 26-200." [PRO:DNx, Reactome:R-HSA-448587]


gene



PR:000001470

interleukin-28B

IFNL3


"An interferon lambda that is a translation product of the human IFNL3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:B4ER10

interferon lambda-3 (chicken)

chick-IFNL3


"An interleukin-28B that is encoded in the genome of chicken." [PRO:CNA]


organism-gene



PR:Q8IZI9

interferon lambda-3 (human)

hIFNL3


"An interleukin-28B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8IZI9]


organism-modification



PR:000047968

interferon lambda-3, signal peptide removed form (human)

hIFNL3/SigPep-


"An interferon lambda-3 (human) that has had the signal peptide removed. UniProtKB:Q8IZI9, 22-196." [PRO:DNx, Reactome:R-HSA-448583]


gene



PR:000001476

interleukin-29

IFNL1


"An interferon lambda that is a translation product of the human IFNL1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8IU54

interferon lambda-1 (human)

hIFNL1


"An interleukin-29 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8IU54]


organism-modification



PR:000047966

interferon lambda-1, signal peptide removed form (human)

hIFNL1/SigPep-


"An interferon lambda-1 (human) that has had the signal peptide removed. UniProtKB:Q8IU54, 20-200." [PRO:DNx, Reactome:R-HSA-448598]