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Protein Ontology report - cytokine receptor common subunit beta
PR:000001339 - http://purl.obolibrary.org/obo/PR_000001339
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001339   
  PRO namecytokine receptor common subunit beta 
  Synonyms
PRO-Short-label: EXACT:CSF2RB
Gene-based: RELATED:IL3RB | IL5RB
Other: EXACT:CD131 | CDw131 | cytokine receptor common beta chain | GM-CSF/IL-3/IL-5 receptor common beta subunit
RELATED:Aic2b | Csf2rb1 | Il3rb1
  Definition"A protein that is a translation product of the human CSF2RB gene or a 1:1 ortholog thereof. This gene encodes the receptor beta chain shared by high-affinity IL5, IL3, and GM-CSF receptors. In mouse, there is also a closely related gene that encodes an IL3-specific beta chain." [PRO:WCB, UniProtKB:P26954] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2306
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001339
cytokine receptor common subunit beta
CSF2RB
"A protein that is a translation product of the human CSF2RB gene or a 1:1 ortholog thereof. This gene encodes the receptor beta chain shared by high-affinity IL5, IL3, and GM-CSF receptors. In mouse, there is also a closely related gene that encodes an IL3-specific beta chain." [PRO:WCB, UniProtKB:P26954]

organism-gene


PR:P32927
cytokine receptor common subunit beta (human)
hCSF2RB
"A cytokine receptor common subunit beta that is encoded in the genome of human." [PRO:WCB, UniProtKB:P32927]

organism-sequence


PR:P32927-1
cytokine receptor common subunit beta isoform 1 (human)
hCSF2RB/iso:1
"A cytokine receptor common subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32927-1." [PRO:DNx, UniProtKB:P32927]

organism-modification


PR:000044814
cytokine receptor common subunit beta isoform 1 phosphorylated 1 (human)
hCSF2RB/iso:1/Phos:1
"A cytokine receptor common subunit beta isoform 1 (human) that has been phosphorylated in the Ser residue within the 14-3-3 recognition motif RSXSXP. UniProtKB:P32927-1, Ser-601, MOD:00046." [PMID:10477722, PMID:10949031, PRO:CNA]
Yes
organism-sequence


PR:P32927-2
cytokine receptor common subunit beta isoform h2 (human)
hCSF2RB/iso:h2
"A cytokine receptor common subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32927-2." [PRO:DNx, UniProtKB:P32927]

organism-modification


PR:000047082
cytokine receptor common subunit beta, signal peptide removed form (human)
hCSF2RB/SigPep-
"A cytokine receptor common subunit beta (human) that has had the signal peptide removed. UniProtKB:P32927, 17-897." [PRO:DNx, Reactome:R-HSA-879960]

organism-modification


PR:000047083
cytokine receptor common subunit beta, signal peptide removed phosphorylated 1 (human)
hCSF2RB/SigPep-/Phos:1
"A cytokine receptor common subunit beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at position 585 of the amino acid sequence represented by UniProtKB:P32927. UniProtKB:P32927, 17-897, Ser-585, MOD:00046." [PRO:DNx, Reactome:R-HSA-914170]

organism-modification


PR:000047084
cytokine receptor common subunit beta, signal peptide removed phosphorylated 2 (human)
hCSF2RB/SigPep-/Phos:2
"A cytokine receptor common subunit beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at position 593 of the amino acid sequence represented by UniProtKB:P32927. UniProtKB:P32927, 17-897, Tyr-593, MOD:00048." [PRO:DNx, Reactome:R-HSA-914092]

organism-modification


PR:000047085
cytokine receptor common subunit beta, signal peptide removed phosphorylated 3 (human)
hCSF2RB/SigPep-/Phos:3
"A cytokine receptor common subunit beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 593 and 628 of the amino acid sequence represented by UniProtKB:P32927. UniProtKB:P32927, 17-897, Tyr-593/Tyr-628, MOD:00048." [PRO:DNx, Reactome:R-HSA-912312]

organism-modification


PR:000063664
cytokine receptor common subunit beta sequence variant S271L, signal peptide removed form (human)
hCSF2RB/var:S271L/SigPep-
"A cytokine receptor common subunit beta (human) that has a Leu residue at the position equivalent to Ser-271 of the amino acid sequence represented by UniProtKB:P32927-1 and that has had the signal peptide removed. Example: UniProtKB:P32927-1, 17-897, Ser-271, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-5688879]

organism-modification


PR:000078162
cytokine receptor common subunit beta methylated 1 (human)
hCSF2RB/Me:1
"A cytokine receptor common subunit beta (human) that has been methylated on the residue at the position equivalent to Cys-45 of the amino acid sequence represented by UniProtKB:P32927-1. Example: UniProtKB:P32927-1, Cys-45, MOD:00660." [IEDB_epitope:1006797, IEDB_epitope:1062715, PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044814 hCSF2RB/iso:1/Phos:1
UniProtKB:P32927-1, Ser-601, MOD:00046		 enablesGO:0071889 14-3-3 protein binding with PR:P63104 hYWHAZ PMID:10477722