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Protein Ontology report - C-type asialoglycoprotein receptor
PR:000001291 - http://purl.obolibrary.org/obo/PR_000001291
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001291   
  PRO nameC-type asialoglycoprotein receptor 
  Definition"A protein that is an integral membrane protein and is responsible for the clearance of desialylated, galactose-terminal glycoproteins from the circulation by receptor-mediated endocytosis. It can be subdivided into four functional domains: the cytosolic domain, the transmembrane domain, the stalk and the carbohydrate recognition domain (CRD). The functional receptor, a galactose lectin, is an oligomer of two types of similar polypeptide chains, each of which weakly binds galactose. High-affinity binding of complex oligosaccharides requires a precise geometric arrangement of receptor subunits. The two subunits have different functions in receptor assembly, ligand binding and endocytosis." [PMID:10891274, PMID:1785139
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 10                                        
         Sequence1                                                  Organism-Sequence 10                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF002424
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001291

C-type asialoglycoprotein receptor

MS4A1


"A protein that is an integral membrane protein and is responsible for the clearance of desialylated, galactose-terminal glycoproteins from the circulation by receptor-mediated endocytosis. It can be subdivided into four functional domains: the cytosolic domain, the transmembrane domain, the stalk and the carbohydrate recognition domain (CRD). The functional receptor, a galactose lectin, is an oligomer of two types of similar polypeptide chains, each of which weakly binds galactose. High-affinity binding of complex oligosaccharides requires a precise geometric arrangement of receptor subunits. The two subunits have different functions in receptor assembly, ligand binding and endocytosis." [PMID:10891274, PMID:1785139]


gene



PR:000001410

C-type lectin domain family 10 member A

CLEC10A


"A C-type asialoglycoprotein receptor that is a translation product of the human CLEC10A gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:F8W3Q0

uncharacterized protein, si:ch73-361h17.1 translation product (zebrafish)

z-CLEC10A


"A C-type lectin domain family 10 member A that is encoded in the genome of zebrafish." [OMA:F8W3Q0, PRO:CNA]


organism-gene



PR:P49300

C-type lectin domain family 10 member A (mouse)

mCLEC10A


"A C-type lectin domain family 10 member A that is encoded in the genome of mouse." [OMA:P49300, PRO:DAN]


organism-gene



PR:P49301

C-type lectin domain family 10 member A (rat)

rCLEC10A


"A C-type lectin domain family 10 member A that is encoded in the genome of rat." [OMA:P49301, PRO:DAN]


organism-gene



PR:Q8IUN9

C-type lectin domain family 10 member A (human)

hCLEC10A


"A C-type lectin domain family 10 member A that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8IUN9]


organism-sequence



PR:Q8IUN9-1

C-type lectin domain family 10 member A isoform h1 (human)

hCLEC10A/iso:h1


"A C-type lectin domain family 10 member A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUN9-1." [PRO:DNx, UniProtKB:Q8IUN9]


organism-sequence



PR:Q8IUN9-2

C-type lectin domain family 10 member A isoform h2 (human)

hCLEC10A/iso:h2


"A C-type lectin domain family 10 member A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUN9-2." [PRO:DNx, UniProtKB:Q8IUN9]


organism-sequence



PR:Q8IUN9-3

C-type lectin domain family 10 member A isoform h3 (human)

hCLEC10A/iso:h3


"A C-type lectin domain family 10 member A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUN9-3." [PRO:DNx, UniProtKB:Q8IUN9]


gene



PR:000004369

asialoglycoprotein receptor 1

ASGR1


"A C-type asialoglycoprotein receptor that is a translation product of the human ASGR1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P02706

asialoglycoprotein receptor 1 (rat)

rASGR1


"An asialoglycoprotein receptor 1 that is encoded in the genome of rat." [OMA:P02706, PRO:DNx]


organism-sequence



PR:P02706-1

asialoglycoprotein receptor 1 isoform 1 (rat)

rASGR1/iso:1


"An asialoglycoprotein receptor 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P07306

asialoglycoprotein receptor 1 (human)

hASGR1


"An asialoglycoprotein receptor 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07306]


organism-sequence



PR:P07306-1

asialoglycoprotein receptor 1 isoform hH1a (human)

hASGR1/iso:hH1a


"An asialoglycoprotein receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07306-1." [PRO:DNx, UniProtKB:P07306]


organism-sequence



PR:P07306-2

asialoglycoprotein receptor 1 isoform hH1b (human)

hASGR1/iso:hH1b


"An asialoglycoprotein receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07306-2." [PRO:DNx, UniProtKB:P07306]


organism-modification



PR:000061468

asialoglycoprotein receptor 1 palmitoylated 1 (human)

hASGR1/Palm:1


"An asialoglycoprotein receptor 1 (human) that has been palmitoylated on the residue at the position equivalent to Cys-36 of the amino acid sequence represented by UniProtKB:P07306-1. Example: UniProtKB:P07306-1, Cys-36, MOD:00069." [PRO:DNx, Reactome:R-HSA-8855714]


organism-gene



PR:P34927

asialoglycoprotein receptor 1 (mouse)

mASGR1


"An asialoglycoprotein receptor 1 that is encoded in the genome of mouse." [OMA:P34927, PRO:DNx]


organism-sequence



PR:P34927-1

asialoglycoprotein receptor 1 isoform 1 (mouse)

mASGR1/iso:1


"An asialoglycoprotein receptor 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000039316

asialoglycoprotein receptor 1 isoform 1

ASGR1/iso:1


"An asialoglycoprotein receptor 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34927-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P02706-1

asialoglycoprotein receptor 1 isoform 1 (rat)

rASGR1/iso:1


"An asialoglycoprotein receptor 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:P34927-1

asialoglycoprotein receptor 1 isoform 1 (mouse)

mASGR1/iso:1


"An asialoglycoprotein receptor 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


modification



PR:000019061

asialoglycoprotein receptor 1, initiator methionine removed form

ASGR1/InitMet-


"An asialoglycoprotein receptor 1 that has had the initiator methionine removed." [PRO:DNx]


gene



PR:000004370

asialoglycoprotein receptor 2

ASGR2


"A C-type asialoglycoprotein receptor that is a translation product of the human ASGR2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P07307

asialoglycoprotein receptor 2 (human)

hASGR2


"An asialoglycoprotein receptor 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07307]


organism-sequence



PR:P07307-1

asialoglycoprotein receptor 2 isoform h1 (human)

hASGR2/iso:h1


"An asialoglycoprotein receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07307-1." [PRO:DNx, UniProtKB:P07307]


organism-sequence



PR:P07307-2

asialoglycoprotein receptor 2 isoform h2 (human)

hASGR2/iso:h2


"An asialoglycoprotein receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07307-2." [PRO:DNx, UniProtKB:P07307]


organism-sequence



PR:P07307-3

asialoglycoprotein receptor 2 isoform h3 (human)

hASGR2/iso:h3


"An asialoglycoprotein receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07307-3." [PRO:DNx, UniProtKB:P07307]


organism-modification



PR:000062893

asialoglycoprotein receptor 2 palmitoylated 1 (human)

hASGR2/Palm:1


"An asialoglycoprotein receptor 2 (human) that has been palmitoylated on the residues at the positions equivalent to Cys-54 and Cys-58 of the amino acid sequence represented by UniProtKB:P07307-1. Example: UniProtKB:P07307-1, Cys-54/Cys-58, MOD:00069." [PRO:DNx, Reactome:R-HSA-8855706]


organism-gene



PR:P08290

asialoglycoprotein receptor 2 (rat)

rASGR2


"An asialoglycoprotein receptor 2 that is encoded in the genome of rat." [OMA:P08290, PRO:DNx]


organism-gene



PR:P24721

asialoglycoprotein receptor 2 (mouse)

mASGR2


"An asialoglycoprotein receptor 2 that is encoded in the genome of mouse." [OMA:P24721, PRO:DNx]