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Protein Ontology report - Toll-like receptor 9
PR:000001160 - http://purl.obolibrary.org/obo/PR_000001160
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001160   
  PRO nameToll-like receptor 9 
  Synonyms
PRO-Short-label: EXACT:TLR9
Gene-based: RELATED:UNQ5798/PRO19605
Other: EXACT:CD289
  Definition"A Toll-like receptor that is a translation product of the human TLR9 gene or a 1:1 ortholog thereof. Non-methylated CpG motifs, present in viral and bacterial DNA, are one of many pathogen-associated molecular patterns (PAMP) recognized by the mammalian innate immune system. Recognition of this PAMP occurs through a specific interaction with Toll-like receptor 9 and this interaction can induce cytokine responses that influence both innate and adaptive immune responses." [PMID:11022119
  PRO Categorygene 
  ParentPR:000001096 Toll-like receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1759
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001160

Toll-like receptor 9

TLR9


"A Toll-like receptor that is a translation product of the human TLR9 gene or a 1:1 ortholog thereof. Non-methylated CpG motifs, present in viral and bacterial DNA, are one of many pathogen-associated molecular patterns (PAMP) recognized by the mammalian innate immune system. Recognition of this PAMP occurs through a specific interaction with Toll-like receptor 9 and this interaction can induce cytokine responses that influence both innate and adaptive immune responses." [PMID:11022119]


organism-gene



PR:Q6Y1S0

Toll-like receptor 9 (rat)

rTLR9


"A Toll-like receptor 9 that is encoded in the genome of rat." [PRO:DAN]


organism-gene



PR:Q9EQU3

Toll-like receptor 9 (mouse)

mTLR9


"A Toll-like receptor 9 that is encoded in the genome of mouse." [PRO:DAN, UniProtKB:Q9EQU3]


organism-gene



PR:Q9NR96

Toll-like receptor 9 (human)

hTLR9


"A Toll-like receptor 9 that is encoded in the genome of human." []


organism-sequence



PR:Q9NR96-1

Toll-like receptor 9 isoform h1 (human)

hTLR9/iso:h1


"A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-1." [PRO:DNx, UniProtKB:Q9NR96]


organism-sequence



PR:Q9NR96-2

Toll-like receptor 9 isoform h2 (human)

hTLR9/iso:h2


"A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-2." [PRO:DNx, UniProtKB:Q9NR96]


organism-sequence



PR:Q9NR96-3

Toll-like receptor 9 isoform h3 (human)

hTLR9/iso:h3


"A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-3." [PRO:DNx, UniProtKB:Q9NR96]


organism-sequence



PR:Q9NR96-4

Toll-like receptor 9 isoform h4 (human)

hTLR9/iso:h4


"A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-4." [PRO:DNx, UniProtKB:Q9NR96]


organism-sequence



PR:Q9NR96-5

Toll-like receptor 9 isoform h5 (human)

hTLR9/iso:h5


"A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-5." [PRO:DNx, UniProtKB:Q9NR96]


organism-modification



PR:000049472

Toll-like receptor 9, signal peptide removed form (human)

hTLR9/SigPep-


"A Toll-like receptor 9 (human) that has had the signal peptide removed. UniProtKB:Q9NR96, 26-1032." [PRO:DNx, Reactome:R-HSA-1678961, Reactome:R-HSA-1678997, Reactome:R-HSA-167979, Reactome:R-HSA-187882]


organism-modification



PR:000065375

Toll-like receptor 9 deaminated 1 (human)

hTLR9/Deam:1


"A Toll-like receptor 9 (human) that has been deaminated on the residue at the position equivalent to Asn-200 of the amino acid sequence represented by UniProtKB:Q9NR96-1. Example: UniProtKB:Q9NR96-1, Asn-200, MOD:00684." [IEDB_epitope:1348832, PRO:DNx]


organism-modification



PR:000069493

Toll-like receptor 9 cysteinylated 1 (human)

hTLR9/Cyst:1


"A Toll-like receptor 9 (human) that has been cysteinylated on the residue at the position equivalent to Cys-35 of the amino acid sequence represented by UniProtKB:Q9NR96-1. Example: UniProtKB:Q9NR96-1, Cys-35, MOD:00765." [IEDB_epitope:1590171, PRO:DNx]


organism-modification



PR:000073643

Toll-like receptor 9 deaminated 2 (human)

hTLR9/Deam:2


"A Toll-like receptor 9 (human) that has been deaminated on the residue at the position equivalent to Gln-335 of the amino acid sequence represented by UniProtKB:Q9NR96-1. Example: UniProtKB:Q9NR96-1, Gln-335, MOD:00685." [IEDB_epitope:1811930, PRO:DNx]


organism-modification



PR:000075252

Toll-like receptor 9 N-glycosylated 1 (human)

hTLR9/NGlyco:1


"A Toll-like receptor 9 (human) that has been N-glycosylated on the residue at the position equivalent to Asn-64 of the amino acid sequence represented by UniProtKB:Q9NR96-1. Example: UniProtKB:Q9NR96-1, Asn-64, MOD:00160." [IEDB_epitope:1074850, PRO:DNx]


organism-modification



PR:000083368

Toll-like receptor 9 deaminated 3 (human)

hTLR9/Deam:3


"A Toll-like receptor 9 (human) that has been deaminated on the residue at the position equivalent to Asn-64 of the amino acid sequence represented by UniProtKB:Q9NR96-1. Example: UniProtKB:Q9NR96-1, Asn-64, MOD:00684." [IEDB_epitope:1339717, IEDB_epitope:836789, PRO:DNx]