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Protein Ontology report - Toll-like receptor 4
PR:000001155 - http://purl.obolibrary.org/obo/PR_000001155
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001155   
  PRO nameToll-like receptor 4 
  Synonyms
PRO-Short-label: EXACT:TLR4
Gene-based: RELATED:Lps
Other: EXACT:CD284
  Definition"A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001096 Toll-like receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1754
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001155
Toll-like receptor 4
TLR4
"A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes
organism-gene


PR:C4PCF3
Toll-like receptor 4 (chicken)
chick-TLR4
"A Toll-like receptor 4 that is encoded in the genome of chicken." [PMID:18768894, PMID:20483729, PRO:CNA]

Yes
organism-gene


PR:O00206
Toll-like receptor 4 (human)
hTLR4
"A Toll-like receptor 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00206]

organism-sequence


PR:O00206-1
Toll-like receptor 4 isoform 1 (human)
hTLR4/iso:1
"A Toll-like receptor 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036075
Toll-like receptor 4 isoform 1, signal peptide removed form (human)
hTLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-sequence


PR:O00206-2
Toll-like receptor 4 isoform 2 (human)
hTLR4/iso:2
"A Toll-like receptor 4 isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:O00206-3
Toll-like receptor 4 isoform h3 (human)
hTLR4/iso:h3
"A Toll-like receptor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00206-3." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000074467
Toll-like receptor 4 deaminated 1 (human)
hTLR4/Deam:1
"A Toll-like receptor 4 (human) that has been deaminated on the residue at the position equivalent to Gln-523 of the amino acid sequence represented by UniProtKB:O00206-1. Example: UniProtKB:O00206-1, Gln-523, MOD:00685." [IEDB_epitope:1353391, PRO:DNx]

organism-modification


PR:000079302
Toll-like receptor 4 deaminated 2 (human)
hTLR4/Deam:2
"A Toll-like receptor 4 (human) that has been deaminated on the residue at the position equivalent to Asn-409 of the amino acid sequence represented by UniProtKB:O00206-1. Example: UniProtKB:O00206-1, Asn-409, MOD:00684." [IEDB_epitope:2000330, PRO:DNx]

organism-modification


PR:000085836
Toll-like receptor 4, signal peptide removed form (human)
hTLR4/SigPep-
"A Toll-like receptor 4 (human) that has had the signal peptide removed. Example: UniProtKB:O00206-1, 24-839." [PRO:DNx, Reactome:R-HSA-2201285]

organism-modification


PR:000036075
Toll-like receptor 4 isoform 1, signal peptide removed form (human)
hTLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-modification


PR:000085995
Toll-like receptor 4, signal peptide removed N-glycosylated 1 (human)
hTLR4/SigPep-/NGlyco:1
"A Toll-like receptor 4 (human) that has had the signal peptide removed and that has been N-glycosylated on the residues at the positions equivalent to Asn-526 and Asn-575 of the amino acid sequence represented by UniProtKB:O00206-1. Example: UniProtKB:O00206-1, 24-839, Asn-526/Asn-575, MOD:00160." [PRO:DNx, Reactome:R-HSA-166045]

organism-gene


PR:Q9QUK6
Toll-like receptor 4 (mouse)
mTLR4
"A Toll-like receptor 4 that is encoded in the genome of mouse." [OMA:Q9QUK6, PRO:DNx]

organism-sequence


PR:Q9QUK6-1
Toll-like receptor 4 isoform 1 (mouse)
mTLR4/iso:1
"A Toll-like receptor 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000027172
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
mTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160." [PMID:17803912, PRO:CNA]

Yes
organism-gene


PR:Q9QX05
Toll-like receptor 4 (rat)
rTLR4
"A Toll-like receptor 4 that is encoded in the genome of rat." [OMA:Q9QX05, PRO:DNx]

sequence


PR:000025490
Toll-like receptor 4 isoform 1
TLR4/iso:1
"A Toll-like receptor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00206-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:O00206-1
Toll-like receptor 4 isoform 1 (human)
hTLR4/iso:1
"A Toll-like receptor 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036075
Toll-like receptor 4 isoform 1, signal peptide removed form (human)
hTLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-sequence


PR:Q9QUK6-1
Toll-like receptor 4 isoform 1 (mouse)
mTLR4/iso:1
"A Toll-like receptor 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000027172
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
mTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160." [PMID:17803912, PRO:CNA]

Yes
modification


PR:000026585
Toll-like receptor 4 isoform 1, signal peptide removed form
TLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1 that has had the signal peptide removed." [PRO:DNx]

Yes
modification


PR:000025492
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1
TLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1 that is the mature N-glycosylated form. Example: UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-modification


PR:000027172
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
mTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160." [PMID:17803912, PRO:CNA]

Yes
organism-modification


PR:000036075
Toll-like receptor 4 isoform 1, signal peptide removed form (human)
hTLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
sequence


PR:000025491
Toll-like receptor 4 isoform 2
TLR4/iso:2
"A Toll-like receptor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00206-2 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:O00206-2
Toll-like receptor 4 isoform 2 (human)
hTLR4/iso:2
"A Toll-like receptor 4 isoform 2 that is encoded in the genome of human." [PRO:CNA]

modification


PR:000018359
Toll-like receptor 4, signal peptide removed form
TLR4/SigPep-
"A Toll-like receptor 4 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000026585
Toll-like receptor 4 isoform 1, signal peptide removed form
TLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1 that has had the signal peptide removed." [PRO:DNx]

Yes
modification


PR:000025492
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1
TLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1 that is the mature N-glycosylated form. Example: UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-modification


PR:000027172
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
mTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160." [PMID:17803912, PRO:CNA]

Yes
organism-modification


PR:000036075
Toll-like receptor 4 isoform 1, signal peptide removed form (human)
hTLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-modification


PR:000085836
Toll-like receptor 4, signal peptide removed form (human)
hTLR4/SigPep-
"A Toll-like receptor 4 (human) that has had the signal peptide removed. Example: UniProtKB:O00206-1, 24-839." [PRO:DNx, Reactome:R-HSA-2201285]

organism-modification


PR:000036075
Toll-like receptor 4 isoform 1, signal peptide removed form (human)
hTLR4/iso:1/SigPep-
"A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]

organism-modification


PR:000025787
Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
hTLR4/iso:1/SigPep-/NGlyco:1
"A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]

Yes
organism-modification


PR:000085995
Toll-like receptor 4, signal peptide removed N-glycosylated 1 (human)
hTLR4/SigPep-/NGlyco:1
"A Toll-like receptor 4 (human) that has had the signal peptide removed and that has been N-glycosylated on the residues at the positions equivalent to Asn-526 and Asn-575 of the amino acid sequence represented by UniProtKB:O00206-1. Example: UniProtKB:O00206-1, 24-839, Asn-526/Asn-575, MOD:00160." [PRO:DNx, Reactome:R-HSA-166045]

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TLR4 forms found in complexes   

TLR4 Component
 Complexes
PR:000001155 TLR4 PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000036003 LY96:TLR4 complex
PR:000036076 activated TLR4 complex
PR:000025492 TLR4/iso:1/SigPep-/NGlyco:1 PR:000025495 lipopolysaccharide receptor complex 1
PR:000025496 lipopolysaccharide receptor complex 2
PR:000025497 lipopolysaccharide receptor complex 3
PR:000025498 lipopolysaccharide receptor complex 4
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:000028678 ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036004 LY96:TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000044684 activated TLR4 complex (human)
PR:000026585 TLR4/iso:1/SigPep- PR:000036078 TIRAP:PIP2:activated TLR4 complex
PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:000027196 TIRAP:PIP2:activated TLR4 (mouse)
PR:000027204 ticam2:activated TLR4 complex (mouse)
PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027217 pTIRAP:PIP2:activated TLR4 complex (mouse)
PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036005 LY96:TLR4 complex (mouse)
PR:000036077 activated TLR4 complex (mouse)
PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000037794 MD2:GB4:TLR4 complex (mouse)
PR:C4PCF3 chick-TLR4 PR:000037473 LY96:TLR4 complex (chicken)
PR:000037474 activated TLR4 complex (chicken)
PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)