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Protein Ontology report - Toll-like receptor 4

PR:000001155 - http://purl.obolibrary.org/obo/PR_000001155

Protein Forms

Complex

Ontology Information

Show OBO stanza

PRO ID

PR:000001155

PRO name

Toll-like receptor 4

Synonyms

PRO-Short-label:	EXACT:	TLR4
Gene-based:	RELATED:	Lps
Other:	EXACT:	CD284

Definition

"A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000001096 Toll-like receptor

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	4
Sequence	2	Organism-Sequence	4
Modification	3	Organism-Modification	7

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	IUPHARobj:1754

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000001155 Toll-like receptor 4

TLR4

Yes

organism-gene

PR:C4PCF3 Toll-like receptor 4 (chicken)

chick-TLR4

Yes

organism-gene

PR:O00206 Toll-like receptor 4 (human)

hTLR4

organism-sequence

PR:O00206-1 Toll-like receptor 4 isoform 1 (human)

hTLR4/iso:1

organism-modification

PR:000036075 Toll-like receptor 4 isoform 1, signal peptide removed form (human)

hTLR4/iso:1/SigPep-

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-sequence

PR:O00206-2 Toll-like receptor 4 isoform 2 (human)

hTLR4/iso:2

organism-sequence

PR:O00206-3 Toll-like receptor 4 isoform h3 (human)

hTLR4/iso:h3

organism-modification

PR:000074467 Toll-like receptor 4 deaminated 1 (human)

hTLR4/Deam:1

organism-modification

PR:000079302 Toll-like receptor 4 deaminated 2 (human)

hTLR4/Deam:2

organism-modification

PR:000085836 Toll-like receptor 4, signal peptide removed form (human)

hTLR4/SigPep-

organism-modification

PR:000036075 Toll-like receptor 4 isoform 1, signal peptide removed form (human)

hTLR4/iso:1/SigPep-

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000085995 Toll-like receptor 4, signal peptide removed N-glycosylated 1 (human)

hTLR4/SigPep-/NGlyco:1

organism-gene

PR:Q9QUK6 Toll-like receptor 4 (mouse)

mTLR4

organism-sequence

PR:Q9QUK6-1 Toll-like receptor 4 isoform 1 (mouse)

mTLR4/iso:1

organism-modification

PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)

mTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-gene

PR:Q9QX05 Toll-like receptor 4 (rat)

rTLR4

sequence

PR:000025490 Toll-like receptor 4 isoform 1

TLR4/iso:1

organism-sequence

PR:O00206-1 Toll-like receptor 4 isoform 1 (human)

hTLR4/iso:1

organism-modification

PR:000036075 Toll-like receptor 4 isoform 1, signal peptide removed form (human)

hTLR4/iso:1/SigPep-

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-sequence

PR:Q9QUK6-1 Toll-like receptor 4 isoform 1 (mouse)

mTLR4/iso:1

organism-modification

PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)

mTLR4/iso:1/SigPep-/NGlyco:1

Yes

modification

PR:000026585 Toll-like receptor 4 isoform 1, signal peptide removed form

TLR4/iso:1/SigPep-

Yes

modification

PR:000025492 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1

TLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)

mTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000036075 Toll-like receptor 4 isoform 1, signal peptide removed form (human)

hTLR4/iso:1/SigPep-

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

sequence

PR:000025491 Toll-like receptor 4 isoform 2

TLR4/iso:2

organism-sequence

PR:O00206-2 Toll-like receptor 4 isoform 2 (human)

hTLR4/iso:2

modification

PR:000018359 Toll-like receptor 4, signal peptide removed form

TLR4/SigPep-

modification

PR:000026585 Toll-like receptor 4 isoform 1, signal peptide removed form

TLR4/iso:1/SigPep-

Yes

modification

PR:000025492 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1

TLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)

mTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000036075 Toll-like receptor 4 isoform 1, signal peptide removed form (human)

hTLR4/iso:1/SigPep-

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000085836 Toll-like receptor 4, signal peptide removed form (human)

hTLR4/SigPep-

organism-modification

PR:000036075 Toll-like receptor 4 isoform 1, signal peptide removed form (human)

hTLR4/iso:1/SigPep-

organism-modification

PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

hTLR4/iso:1/SigPep-/NGlyco:1

Yes

organism-modification

PR:000085995 Toll-like receptor 4, signal peptide removed N-glycosylated 1 (human)

hTLR4/SigPep-/NGlyco:1

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TLR4 forms found in complexes

TLR4 Component	Complexes
PR:000001155 TLR4	PR:000025784 MYD88:TIRAP:activated TLR4 receptor
	PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
	PR:000036003 LY96:TLR4 complex
	PR:000036076 activated TLR4 complex
PR:000025492 TLR4/iso:1/SigPep-/NGlyco:1	PR:000025495 lipopolysaccharide receptor complex 1
	PR:000025496 lipopolysaccharide receptor complex 2
	PR:000025497 lipopolysaccharide receptor complex 3
	PR:000025498 lipopolysaccharide receptor complex 4
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1	PR:000025773 lipopolysaccharide receptor complex 3 (human)
	PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
	PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
	PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
	PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
	PR:000028678 ticam2:activated TLR4 complex (human)
	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
	PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
	PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
	PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036004 LY96:TLR4 complex (human)
	PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
	PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
	PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
	PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
	PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
	PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
	PR:000037479 lipopolysaccharide receptor complex 4 (human)
	PR:000044684 activated TLR4 complex (human)
PR:000026585 TLR4/iso:1/SigPep-	PR:000036078 TIRAP:PIP2:activated TLR4 complex
PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1	PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
	PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
	PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
	PR:000027196 TIRAP:PIP2:activated TLR4 (mouse)
	PR:000027204 ticam2:activated TLR4 complex (mouse)
	PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000027217 pTIRAP:PIP2:activated TLR4 complex (mouse)
	PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
	PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
	PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
	PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036005 LY96:TLR4 complex (mouse)
	PR:000036077 activated TLR4 complex (mouse)
	PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
	PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
	PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
	PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
	PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
	PR:000037794 MD2:GB4:TLR4 complex (mouse)
PR:C4PCF3 chick-TLR4	PR:000037473 LY96:TLR4 complex (chicken)
	PR:000037474 activated TLR4 complex (chicken)
	PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)