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family
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PR:000001092 |
interleukin-17
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fam:IL-17
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"A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses." [PMID:17982105, PMID:18280574]
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Yes |
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gene
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PR:000001113 |
interleukin-25
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IL25
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"An interleukin-17 that is a translation product of the human IL25 gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:Q8VHH8 |
interleukin-25 (mouse)
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mIL25
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"An interleukin-25 that is encoded in the genome of mouse." [OMA:Q8VHH8, PRO:DNx]
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organism-gene
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PR:Q9H293 |
interleukin-25 (human)
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hIL25
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"An interleukin-25 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9H293]
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organism-sequence
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PR:Q9H293-1 |
interleukin-25 isoform h1 (human)
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hIL25/iso:h1
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"An interleukin-25 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H293-1." [PRO:DNx, UniProtKB:Q9H293]
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organism-sequence
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PR:Q9H293-2 |
interleukin-25 isoform h2 (human)
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hIL25/iso:h2
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"An interleukin-25 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H293-2." [PRO:DNx, UniProtKB:Q9H293]
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organism-modification
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PR:000048012 |
interleukin-25, signal peptide removed form (human)
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hIL25/SigPep-
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"An interleukin-25 (human) that has had the signal peptide removed. UniProtKB:Q9H293, 33-177." [PRO:DNx, Reactome:R-HSA-447101]
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modification
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PR:000018341 |
interleukin-25, signal peptide removed form
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IL25/SigPep-
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"An interleukin-25 that has had the signal peptide removed." [PRO:DNx]
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organism-modification
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PR:000048012 |
interleukin-25, signal peptide removed form (human)
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hIL25/SigPep-
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"An interleukin-25 (human) that has had the signal peptide removed. UniProtKB:Q9H293, 33-177." [PRO:DNx, Reactome:R-HSA-447101]
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gene
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PR:000001138 |
interleukin-17A
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IL17A
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"An interleukin-17 that is a translation product of the human IL17A gene or a 1:1 ortholog thereof. The active product is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases." [PRO:CNA, Wikipedia:IL17A]
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organism-gene
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PR:Q16552 |
interleukin-17A (human)
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hIL17A
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"An interleukin-17A that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16552]
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organism-modification
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PR:000036602 |
interleukin-17A, signal peptide removed form (human)
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hIL17A/SigPep-
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"An interleukin-17A, signal peptide removed form in human. UniProtKB:Q16552, 24-155." [PMID:15055556, PMID:15340161, PMID:7499828, PRO:CNA]
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Yes |
Yes |
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organism-gene
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PR:Q5TKT0 |
interleukin 17_5 (zebrafish)
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z-IL17A
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"An interleukin-17A that is encoded in the genome of zebrafish." [PRO:CNA]
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organism-gene
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PR:Q61453 |
interleukin-17A (rat)
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rIL17A
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"An interleukin-17A that is encoded in the genome of rat." [OMA:Q61453, PRO:DNx]
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organism-gene
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PR:Q62386 |
interleukin-17A (mouse)
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mIL17A
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"An interleukin-17A that is encoded in the genome of mouse." [OMA:Q62386, PRO:DNx]
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modification
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PR:000018349 |
interleukin-17A, signal peptide removed form
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IL17A/SigPep-
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"An interleukin-17A that has had the signal peptide removed." [PRO:DNx]
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organism-modification
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PR:000036602 |
interleukin-17A, signal peptide removed form (human)
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hIL17A/SigPep-
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"An interleukin-17A, signal peptide removed form in human. UniProtKB:Q16552, 24-155." [PMID:15055556, PMID:15340161, PMID:7499828, PRO:CNA]
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Yes |
Yes |
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modification
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PR:000025428 |
interleukin-17A proteolytic cleavage product
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IL17A/ClvPrd
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"An interleukin-17A that has been processed by proteolytic cleavage." [PRO:DNx]
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gene
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PR:000001139 |
interleukin-17B
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IL17B
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"An interleukin-17 that is a translation product of the human IL17B gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:Q9QXT6 |
interleukin-17B (mouse)
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mIL17B
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"An interleukin-17B that is encoded in the genome of mouse." [OMA:Q9QXT6, PRO:DNx]
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organism-sequence
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PR:Q9QXT6-1 |
interleukin-17B isoform 1 (mouse)
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mIL17B/iso:1
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"An interleukin-17B isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
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organism-gene
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PR:Q9UHF5 |
interleukin-17B (human)
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hIL17B
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"An interleukin-17B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UHF5]
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organism-sequence
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PR:Q9UHF5-1 |
interleukin-17B isoform 1 (human)
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hIL17B/iso:1
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"An interleukin-17B isoform 1 that is encoded in the genome of human." [PRO:DNx]
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sequence
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PR:000043889 |
interleukin-17B isoform 1
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IL17B/iso:1
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"An interleukin-17B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UHF5-1 or a 1:1 ortholog thereof." [PRO:DNx]
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organism-sequence
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PR:Q9QXT6-1 |
interleukin-17B isoform 1 (mouse)
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mIL17B/iso:1
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"An interleukin-17B isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
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organism-sequence
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PR:Q9UHF5-1 |
interleukin-17B isoform 1 (human)
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hIL17B/iso:1
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"An interleukin-17B isoform 1 that is encoded in the genome of human." [PRO:DNx]
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gene
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PR:000001140 |
interleukin-17C
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IL17C
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"An interleukin-17 that is a translation product of the human IL17C gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:Q8K4C5 |
interleukin-17C (mouse)
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mIL17C
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"An interleukin-17C that is encoded in the genome of mouse." [OMA:Q8K4C5, PRO:DNx]
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organism-gene
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PR:Q9P0M4 |
interleukin-17C (human)
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hIL17C
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"An interleukin-17C that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9P0M4]
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organism-modification
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PR:000047989 |
interleukin-17C, signal peptide removed form (human)
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hIL17C/SigPep-
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"An interleukin-17C (human) that has had the signal peptide removed. UniProtKB:Q9P0M4, 19-197." [PRO:DNx, Reactome:R-HSA-447182]
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gene
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PR:000001141 |
interleukin-17D
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IL17D
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"An interleukin-17 that is a translation product of the human IL17D gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:Q8TAD2 |
interleukin-17D (human)
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hIL17D
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"An interleukin-17D that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8TAD2]
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gene
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PR:000001142 |
interleukin-17F
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IL17F
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"An interleukin-17 that is a translation product of the human IL17F gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:Q5BJ95 |
interleukin-17F (rat)
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rIL17F
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"An interleukin-17F that is encoded in the genome of rat." [OMA:Q5BJ95, PRO:DNx]
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organism-gene
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PR:Q7TNI7 |
interleukin-17F (mouse)
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mIL17F
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"An interleukin-17F that is encoded in the genome of mouse." [OMA:Q7TNI7, PRO:DNx]
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organism-sequence
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PR:Q7TNI7-1 |
interleukin-17F isoform m1 (mouse)
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mIL17F/iso:m1
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"An interleukin-17F (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TNI7-1." [PRO:DNx, UniProtKB:Q7TNI7]
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organism-sequence
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PR:Q7TNI7-2 |
interleukin-17F isoform m2 (mouse)
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mIL17F/iso:m2
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"An interleukin-17F (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TNI7-2." [PRO:DNx, UniProtKB:Q7TNI7]
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organism-gene
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PR:Q96PD4 |
interleukin-17F (human)
|
hIL17F
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"An interleukin-17F that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96PD4]
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organism-modification
|
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PR:000044527 |
interleukin-17F, signal peptide removed form (human)
|
hIL17F/SigPep-
|
"An interleukin-17F, signal peptide removed form in human. UniProtKB:Q96PD4, 31-163." [PRO:DAN]
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Yes |
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modification
|
|
PR:000018351 |
interleukin-17F, signal peptide removed form
|
IL17F/SigPep-
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"An interleukin-17F that has had the signal peptide removed." [PRO:DNx]
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organism-modification
|
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PR:000044527 |
interleukin-17F, signal peptide removed form (human)
|
hIL17F/SigPep-
|
"An interleukin-17F, signal peptide removed form in human. UniProtKB:Q96PD4, 31-163." [PRO:DAN]
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Yes |
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