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Protein Ontology report - T-cell surface glycoprotein CD8 alpha chain
PR:000001084 - http://purl.obolibrary.org/obo/PR_000001084
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001084   
  PRO nameT-cell surface glycoprotein CD8 alpha chain 
  Synonyms
PRO-Short-label: EXACT:CD8A
Gene-based: RELATED:Lyt-2 | Lyt2 | MAL
Other: EXACT:CD8a | T-cell surface glycoprotein Lyt-2 | T-lymphocyte differentiation antigen T8/Leu-2
  Definition"A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PMID:11114424, PRO:CNA, Wikipedia:CD8
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001084

T-cell surface glycoprotein CD8 alpha chain

CD8A


"A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PMID:11114424, PRO:CNA, Wikipedia:CD8]


organism-gene



PR:F1NXT4

uncharacterized protein, CD8A translation product (chicken)

chick-CD8A


"A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of chicken." [PRO:CNA]


organism-gene



PR:P01731

T-cell surface glycoprotein CD8 alpha chain (mouse)

mCD8A


"A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse." [OMA:P01731, PRO:DNx]


organism-sequence



PR:P01731-1

T-cell surface glycoprotein CD8 alpha chain isoform m1 (mouse)

mCD8A/iso:m1


"A T-cell surface glycoprotein CD8 alpha chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01731-1." [PRO:DNx, UniProtKB:P01731]


organism-gene



PR:P01732

T-cell surface glycoprotein CD8 alpha chain (human)

hCD8A


"A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01732]


organism-sequence



PR:P01732-1

T-cell surface glycoprotein CD8 alpha chain isoform 1 (human)

hCD8A/iso:1


"A T-cell surface glycoprotein CD8 alpha chain isoform 1 that is encoded in the genome of human." [PRO:DAN]


organism-sequence



PR:P01732-2

T-cell surface glycoprotein CD8 alpha chain isoform 2 (human)

hCD8A/iso:2


"A T-cell surface glycoprotein CD8 alpha chain isoform 2 that is encoded in the genome of human." [PRO:DAN]


organism-sequence



PR:P01732-3

T-cell surface glycoprotein CD8 alpha chain isoform h3 (human)

hCD8A/iso:h3


"A T-cell surface glycoprotein CD8 alpha chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-3." [PRO:DNx, UniProtKB:P01732]


organism-modification



PR:000046653

T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form (human)

hCD8A/SigPep-


"A T-cell surface glycoprotein CD8 alpha chain (human) that has had the signal peptide removed. UniProtKB:P01732, 22-235." [PRO:DNx, Reactome:R-HSA-197601]


organism-modification



PR:000052042

T-cell surface glycoprotein CD8 alpha chain O-glycosylated 1 (human)

hCD8A/OGlyco:1


"A T-cell surface glycoprotein CD8 alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-158 of the amino acid sequence represented by UniProtKB:P01732-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G29068FM." [GlyGen:P01732-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000052043

T-cell surface glycoprotein CD8 alpha chain O-glycosylated 2 (human)

hCD8A/OGlyco:2


"A T-cell surface glycoprotein CD8 alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-158 of the amino acid sequence represented by UniProtKB:P01732-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G43417UB." [GlyGen:P01732-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P07725

T-cell surface glycoprotein CD8 alpha chain (rat)

rCD8A


"A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of rat." [OMA:P07725, PRO:DNx]


sequence



PR:000025403

T-cell surface glycoprotein CD8 alpha chain isoform 1

CD8A/iso:1


"A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." [PRO:DAN]


organism-sequence



PR:P01732-1

T-cell surface glycoprotein CD8 alpha chain isoform 1 (human)

hCD8A/iso:1


"A T-cell surface glycoprotein CD8 alpha chain isoform 1 that is encoded in the genome of human." [PRO:DAN]


modification



PR:000025406

T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form

CD8A/iso:1/SigPep-


"A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." [PRO:DAN]


modification



PR:000025408

T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form

CD8A/iso:1/SigPep-/GlycoRes+


"A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PRO:DAN]


Yes
sequence



PR:000025404

T-cell surface glycoprotein CD8 alpha chain isoform 2

CD8A/iso:2


"A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-2 or a 1:1 ortholog thereof. Lacking the transmembrane domain found in isoform mCD8alpha, this form is therefore secreted." [PRO:DAN]


organism-sequence



PR:P01732-2

T-cell surface glycoprotein CD8 alpha chain isoform 2 (human)

hCD8A/iso:2


"A T-cell surface glycoprotein CD8 alpha chain isoform 2 that is encoded in the genome of human." [PRO:DAN]


modification



PR:000018335

T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form

CD8A/SigPep-


"A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed." [PRO:DNx]


modification



PR:000025406

T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form

CD8A/iso:1/SigPep-


"A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." [PRO:DAN]


modification



PR:000025408

T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form

CD8A/iso:1/SigPep-/GlycoRes+


"A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PRO:DAN]


Yes
organism-modification



PR:000046653

T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form (human)

hCD8A/SigPep-


"A T-cell surface glycoprotein CD8 alpha chain (human) that has had the signal peptide removed. UniProtKB:P01732, 22-235." [PRO:DNx, Reactome:R-HSA-197601]


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CD8A forms found in complexes   

CD8A Component
Complexes
PR:000025408 CD8A/iso:1/SigPep-/GlycoRes+ PR:000025402 T cell receptor co-receptor CD8