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Protein Ontology report - transient receptor potential cation channel TRPC with PDZ-binding motif
PR:000001074 - http://purl.obolibrary.org/obo/PR_000001074
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001074   
  PRO nametransient receptor potential cation channel TRPC with PDZ-binding motif 
  Definition"A transient receptor potential cation channel TRPC with a carboxyl-terminal PDZ-binding motif (VTTRL). They form homomeric or heteromeric (with TRPC1) cation channels that are activated following stimulation of Gq-coupled receptors." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000680 transient receptor potential cation channel TRPC
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001074

transient receptor potential cation channel TRPC with PDZ-binding motif

TRPV4/iso:E


"A transient receptor potential cation channel TRPC with a carboxyl-terminal PDZ-binding motif (VTTRL). They form homomeric or heteromeric (with TRPC1) cation channels that are activated following stimulation of Gq-coupled receptors." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB]


gene



PR:000001075

short transient receptor potential cation channel TRPC4

TRPC4


"A transient receptor potential cation channel TRPC with PDZ-binding motif that is a translation product of the human TRPC4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O35119

short transient receptor potential channel 4 (rat)

rTRPC4


"A short transient receptor potential cation channel TRPC4 that is encoded in the genome of rat." [OMA:O35119, PRO:DNx]


organism-sequence



PR:O35119-1

short transient receptor potential channel 4 isoform alpha (rat)

rTRPC4/iso:Alpha


"A short transient receptor potential cation channel TRPC4 isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-sequence



PR:O35119-2

short transient receptor potential channel 4 isoform beta (rat)

rTRPC4/iso:Beta


"A short transient receptor potential cation channel TRPC4 isoform 2 that is encoded in the genome of rat." [PRO:CNA]


organism-gene



PR:Q9QUQ5

short transient receptor potential channel 4 (mouse)

mTRPC4


"A short transient receptor potential cation channel TRPC4 that is encoded in the genome of mouse." [OMA:Q9QUQ5, PRO:DNx]

Yes

organism-sequence



PR:Q9QUQ5-1

short transient receptor potential channel 4 isoform alpha (mouse)

mTRPC4/iso:Alpha


"A short transient receptor potential cation channel TRPC4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q9QUQ5-2

short transient receptor potential channel 4 isoform beta (mouse)

mTRPC4/iso:Beta


"A short transient receptor potential cation channel TRPC4 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q9UBN4

short transient receptor potential channel 4 (human)

hTRPC4


"A short transient receptor potential cation channel TRPC4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UBN4]


organism-sequence



PR:Q9UBN4-1

short transient receptor potential channel 4 isoform alpha (human)

hTRPC4/iso:Alpha


"A short transient receptor potential cation channel TRPC4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9UBN4-2

short transient receptor potential channel 4 isoform beta (human)

hTRPC4/iso:Beta


"A short transient receptor potential cation channel TRPC4 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9UBN4-3

short transient receptor potential channel 4 isoform delta (human)

hTRPC4/iso:Delta


"A short transient receptor potential cation channel TRPC4 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9UBN4-4

short transient receptor potential channel 4 isoform gamma (human)

hTRPC4/iso:Gamma


"A short transient receptor potential cation channel TRPC4 isoform 4 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9UBN4-5

short transient receptor potential channel 4 isoform Epsilon (human)

hTRPC4/iso:Epsilon


"A short transient receptor potential channel 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBN4-5." [PRO:DNx, UniProtKB:Q9UBN4]


organism-sequence



PR:Q9UBN4-6

short transient receptor potential channel 4 isoform Zeta (human)

hTRPC4/iso:Zeta


"A short transient receptor potential channel 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBN4-6." [PRO:DNx, UniProtKB:Q9UBN4]


organism-sequence



PR:Q9UBN4-7

short transient receptor potential channel 4 isoform Eta (human)

hTRPC4/iso:Eta


"A short transient receptor potential channel 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBN4-7." [PRO:DNx, UniProtKB:Q9UBN4]


sequence



PR:000001076

short transient receptor potential cation channel TRPC4 isoform 1

TRPC4/iso:1


"A short transient receptor potential cation channel TRPC4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBN4-1 or a 1:1 ortholog thereof." [PMID:11163362, PRO:CNA]


organism-sequence



PR:O35119-1

short transient receptor potential channel 4 isoform alpha (rat)

rTRPC4/iso:Alpha


"A short transient receptor potential cation channel TRPC4 isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-sequence



PR:Q9QUQ5-1

short transient receptor potential channel 4 isoform alpha (mouse)

mTRPC4/iso:Alpha


"A short transient receptor potential cation channel TRPC4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q9UBN4-1

short transient receptor potential channel 4 isoform alpha (human)

hTRPC4/iso:Alpha


"A short transient receptor potential cation channel TRPC4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000001077

short transient receptor potential cation channel TRPC4 isoform 2

TRPC4/iso:2


"A short transient receptor potential cation channel TRPC4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBN4-2 or a 1:1 ortholog thereof. This form lacks a region of around 84 residues at the C-terminal domain, but conserves the PDZ-binding motif as compared to isoform 1." [PMID:11713258, PRO:CNA]


organism-sequence



PR:O35119-2

short transient receptor potential channel 4 isoform beta (rat)

rTRPC4/iso:Beta


"A short transient receptor potential cation channel TRPC4 isoform 2 that is encoded in the genome of rat." [PRO:CNA]


organism-sequence



PR:Q9QUQ5-2

short transient receptor potential channel 4 isoform beta (mouse)

mTRPC4/iso:Beta


"A short transient receptor potential cation channel TRPC4 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9UBN4-2

short transient receptor potential channel 4 isoform beta (human)

hTRPC4/iso:Beta


"A short transient receptor potential cation channel TRPC4 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000001078

short transient receptor potential cation channel TRPC4 isoform 3

TRPC4/iso:3


"A short transient receptor potential cation channel TRPC4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBN4-3 or a 1:1 ortholog thereof. This form lacks a region of around 140 residues at the C-terminal domain, but conserves the PDZ-binding motif as compared to isoform 1." [PMID:11163362, PRO:CNA]


organism-sequence



PR:Q9UBN4-3

short transient receptor potential channel 4 isoform delta (human)

hTRPC4/iso:Delta


"A short transient receptor potential cation channel TRPC4 isoform 3 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000001079

short transient receptor potential cation channel TRPC4 isoform 4

TRPC4/iso:4


"A short transient receptor potential cation channel TRPC4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBN4-4 or a 1:1 ortholog thereof." [PMID:11163362, PRO:CNA]


organism-sequence



PR:Q9UBN4-4

short transient receptor potential channel 4 isoform gamma (human)

hTRPC4/iso:Gamma


"A short transient receptor potential cation channel TRPC4 isoform 4 that is encoded in the genome of human." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9QUQ5 mTRPC4 acts_upstream_of_or_withinGO:0014051 gamma-aminobutyric acid secretion PMID:14668438
located_inGO:0005901 caveola PMID:11897792
PR:Q9QUQ5-1 mTRPC4/iso:Alpha enablesGO:0015279 store-operated calcium channel activity MGI_ref:3525810; PMID:15044151
located_inGO:0005886 plasma membrane MGI_ref:3525810; PMID:15044151
PR:Q9UBN4-1 hTRPC4/iso:Alpha enablescontributes_to GO:0015279 store-operated calcium channel activity PMID:11713258
GO:0042802 identical protein binding PMID:11713258
located_inGO:0005886 plasma membrane PMID:11713258
PR:Q9UBN4-2 hTRPC4/iso:Beta enablescontributes_to GO:0015279 store-operated calcium channel activity PMID:11713258
GO:0042802 identical protein binding PMID:11713258
located_inGO:0005886 plasma membrane PMID:11713258