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Protein Ontology report - cftr isoform 1
PR:000001045 - http://purl.obolibrary.org/obo/PR_000001045
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001045   
  PRO namecftr isoform 1 
  Synonyms
PRO-Short-label: EXACT:CFTR/iso:1
Other: EXACT:cystic fibrosis transmembrane conductance regulator isoform 1
  Definition"A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-1 or a 1:1 ortholog thereof." [PMID:9922375, PRO:CNA, PRO:DAN] 
  CommentNote: This isoform contains an intracellular regulatory domain (R-domain) that, when unphosphorylated, inhibits CFTR. Phosphorylation of the R-domain removes this inhibition, allowing activation of chloride flux. 
  PRO Categorysequence 
  ParentPR:000001044 cystic fibrosis transmembrane conductance regulator
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000001045

cftr isoform 1

CFTR/iso:1


"A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-1 or a 1:1 ortholog thereof." [PMID:9922375, PRO:CNA, PRO:DAN]


organism-sequence



PR:P13569-1

cystic fibrosis transmembrane conductance regulator isoform 1 (human)

hCFTR/iso:1


"A cftr isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036593

cftr isoform 1 N-glycosylated 1 (human)

hCFTR/iso:1/NGlyco:1


"A cftr isoform 1 N-glycosylated 1 in human. UniProtKB:P13569-1, Asn-894/Asn-900, MOD:00160." [PMID:7518437, PRO:CNA]


organism-modification



PR:000036594

cftr isoform 1 phosphorylated 1 (human)

hCFTR/iso:1/Phos:1


"A cftr isoform 1 phosphorylated 1 in human. Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047, PMID:1716180, PRO:CNA]

Yes

organism-modification



PR:000036595

cftr isoform 1 phosphorylated 2 (human)

hCFTR/iso:1/Phos:2


"A cftr isoform 1 phosphorylated 2 in human. Example: UniProtKB:P13569-1, Ser-686/Ser-737/Ser-768/Ser-790/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PRO:CNA]


organism-sequence



PR:P26361-1

cystic fibrosis transmembrane conductance regulator isoform 1 (mouse)

mCFTR/iso:1


"A cftr isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P34158-1

cystic fibrosis transmembrane conductance regulator isoform 1 (rat)

rCFTR/iso:1


"A cftr isoform 1 that is encoded in the genome of rat." [PRO:CNA]


modification



PR:000001048

cftr isoform 1 glycosylated form

CFTR/iso:1/GlycoRes+


"A cftr isoform 1 that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000001049

cftr isoform 1 N-glycosylated 1

CFTR/iso:1/NGlyco:1


"A cftr isoform 1 glycosylated form in which the glycosylation is at two Asn residues within the N{P}[ST]{P} motif, located in the fourth extracellular loop. Example: UniProtKB:P13569-1, Asn-894/Asn-900, MOD:00160." [PMID:7518437]


organism-modification



PR:000036593

cftr isoform 1 N-glycosylated 1 (human)

hCFTR/iso:1/NGlyco:1


"A cftr isoform 1 N-glycosylated 1 in human. UniProtKB:P13569-1, Asn-894/Asn-900, MOD:00160." [PMID:7518437, PRO:CNA]


modification



PR:000001050

cftr isoform 1 phosphorylated form

CFTR/iso:1/PhosRes+


"A cftr isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000001051

cftr isoform 1 phosphorylated 1

CFTR/iso:1/Phos:1


"A cftr isoform 1 phosphorylated form in which the phosphorylation occurs at multiple Ser and/or Thr residues within the PKA consensus sites R[RK]x [ST] located within the regulatory domain (R-domain). Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047]


organism-modification



PR:000036594

cftr isoform 1 phosphorylated 1 (human)

hCFTR/iso:1/Phos:1


"A cftr isoform 1 phosphorylated 1 in human. Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047, PMID:1716180, PRO:CNA]

Yes

modification



PR:000001052

cftr isoform 1 phosphorylated 2

CFTR/iso:1/Phos:2


"A cftr isoform 1 phosphorylated form in which the phosphorylation occurs by the action of PKA and PKC at multiple Ser and/or Thr residues within the regulatory domain (R-domain). Example: UniProtKB:P13569-1, Ser-686/Ser-737/Ser-768/Ser-790/Ser-795/Ser-813, MOD:00046." [PMID:1377674]


organism-modification



PR:000036595

cftr isoform 1 phosphorylated 2 (human)

hCFTR/iso:1/Phos:2


"A cftr isoform 1 phosphorylated 2 in human. Example: UniProtKB:P13569-1, Ser-686/Ser-737/Ser-768/Ser-790/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036594 hCFTR/iso:1/Phos:1
Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046
enablesGO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180
GO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180