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Protein Ontology report - Na(+)/H(+) exchange regulatory cofactor NHE-RF1
PR:000001041 - http://purl.obolibrary.org/obo/PR_000001041
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001041   
  PRO nameNa(+)/H(+) exchange regulatory cofactor NHE-RF1 
  Synonyms
PRO-Short-label: EXACT:NHERF1
Gene-based: RELATED:NHERF | SLC9A3R1
Other: EXACT:EBP50 | ezrin-radixin-moesin-binding phosphoprotein 50 | NHERF-1 | regulatory cofactor of Na(+)/H(+) exchanger | sodium-hydrogen exchanger regulatory factor 1 | solute carrier family 9 isoform A3 regulatory factor 1
  Definition"A Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain that is a translation product of the human NHERF1 gene or a 1:1 ortholog thereof. It contains two copies of the PDZ domain at the N terminus and an EBP50 domain at the C-terminus. The latter allows interaction with FERM domains, resulting in the activation of ERM proteins (PR:000001030), with subsequent cytoskeletal modulation and cellular growth control." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001043 Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001041
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
NHERF1
"A Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain that is a translation product of the human NHERF1 gene or a 1:1 ortholog thereof. It contains two copies of the PDZ domain at the N terminus and an EBP50 domain at the C-terminus. The latter allows interaction with FERM domains, resulting in the activation of ERM proteins (PR:000001030), with subsequent cytoskeletal modulation and cellular growth control." [PRO:CNA]

organism-gene


PR:O14745
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human)
hNHERF1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O14745]

organism-sequence


PR:O14745-1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (human)
hNHERF1/iso:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:O14745-2
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform h2 (human)
hNHERF1/iso:h2
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14745-2." [PRO:DNx, UniProtKB:O14745]

organism-modification


PR:000084870
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 methylated 1 (human)
hNHERF1/Me:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human) that has been methylated on the residue at the position equivalent to Cys-206 of the amino acid sequence represented by UniProtKB:O14745-1. Example: UniProtKB:O14745-1, Cys-206, MOD:00660." [IEDB_epitope:1010282, PRO:DNx]

organism-gene


PR:P70441
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (mouse)
mNHERF1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of mouse." [OMA:P70441, PRO:DNx]

organism-sequence


PR:P70441-1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (mouse)
mNHERF1/iso:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-sequence


PR:P70441-2
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2 (mouse)
mNHERF1/iso:2
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000046189
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 phosphorylated 1 (mouse)
mNHERF1/Phos:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-77 of the amino acid sequence represented by UniProtKB:P70441-1. Example: UniProtKB:P70441-1, Ser-77, MOD:00046." [iPTMnet:P70441, PMID:17975671]

organism-gene


PR:Q5ZM14
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (chicken)
chick-NHERF1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of chicken." [PRO:CNA]

organism-gene


PR:Q9JJ19
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (rat)
rNHERF1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of rat." [OMA:Q9JJ19, PRO:DNx]

organism-sequence


PR:Q9JJ19-1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (rat)
rNHERF1/iso:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]

sequence


PR:000001042
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1
NHERF1/iso:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14745-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:O14745-1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (human)
hNHERF1/iso:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:P70441-1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (mouse)
mNHERF1/iso:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-sequence


PR:Q9JJ19-1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (rat)
rNHERF1/iso:1
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]

modification


PR:000026596
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1, initiator methionine removed form
NHERF1/iso:1/InitMet-
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

sequence


PR:000001058
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2
NHERF1/iso:2
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70441-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P70441-2
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2 (mouse)
mNHERF1/iso:2
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000018331
Na(+)/H(+) exchange regulatory cofactor NHE-RF1, initiator methionine removed form
NHERF1/InitMet-
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that has had the initiator methionine removed." [PRO:DNx]

modification


PR:000026596
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1, initiator methionine removed form
NHERF1/iso:1/InitMet-
"A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P70441-1 mNHERF1/iso:1 enablesGO:0051219 phosphoprotein binding with PR:000044790 mEZR/iso:1/Phos:5 PMID:15591354
located_inGO:0031526 brush border membrane PMID:15591354