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Protein Ontology report - T-cell surface glycoprotein CD3
PR:000001027 - http://purl.obolibrary.org/obo/PR_000001027
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001027   
  PRO nameT-cell surface glycoprotein CD3 
  Synonyms
PRO-Short-label: EXACT:CD247
Gene-based: RELATED:CD3Z | T3Z | TCRZ
Other: EXACT:T-cell receptor T3 eta chain | T-cell receptor T3 zeta chain
  Definition"A protein that is a translation product of the human CD247 gene or a 1:1 ortholog thereof. It consists of an extracellular short N-terminal domain, a transmembrane domain, and an intracellular C-terminal domain with two to three copies of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM)." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF028738
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001027
T-cell surface glycoprotein CD3
CD247
"A protein that is a translation product of the human CD247 gene or a 1:1 ortholog thereof. It consists of an extracellular short N-terminal domain, a transmembrane domain, and an intracellular C-terminal domain with two to three copies of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM)." [PRO:CNA]

organism-gene


PR:P20963
T-cell surface glycoprotein CD3 (human)
hCD247
"A T-cell surface glycoprotein CD3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P20963]

organism-sequence


PR:P20963-1
T-cell surface glycoprotein CD3 zeta chain (human)
hCD247/iso:CD3 zeta
"A T-cell surface glycoprotein CD3 isoform CD3 zeta that is encoded in the genome of human." [PRO:DNx, UniProtKB:P20963]

organism-modification


PR:000036628
T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 (human)
hCD247/iso:CD3 zeta/Phos:1
"A T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 in human." [PMID:9043947, PRO:CL]
Yes
organism-modification


PR:000061848
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed form (human)
hCD247/iso:CD3 zeta/SigPep-
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed. UniProtKB:P20963-1, 22-164." [PRO:DNx, Reactome:R-HSA-198166]

organism-modification


PR:000063475
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)
hCD247/iso:CD3 zeta/SigPep-/Phos:1
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]

organism-sequence


PR:P20963-2
T-cell surface glycoprotein CD3 eta chain (human)
hCD247/iso:CD3 eta
"A T-cell surface glycoprotein CD3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20963-2." [PRO:DNx, UniProtKB:P20963]

organism-sequence


PR:P20963-3
T-cell surface glycoprotein CD3 isoform 3 (human)
hCD247/iso:3
"A T-cell surface glycoprotein CD3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20963-3." [PRO:DNx, UniProtKB:P20963]

organism-gene


PR:P24161
T-cell surface glycoprotein CD3 isoforms eta/zeta (mouse)
mCD247
"A T-cell surface glycoprotein CD3 that is encoded in the genome of mouse." [OMA:P24161, PRO:DAN]

organism-sequence


PR:P24161-1
T-cell surface glycoprotein CD3 zeta chain (mouse)
mCD247/iso:CD3 zeta
"A T-cell surface glycoprotein CD3 isoform CD3 zeta that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P24161]

organism-sequence


PR:P24161-2
T-cell surface glycoprotein CD3 eta (mouse)
mCD247/iso:CD3 eta
"A T-cell surface glycoprotein CD3 isoform CD3 eta that is encoded in the genome of mouse." [PRO:DAN, UniProtKB:P24161]

sequence


PR:000001028
T-cell surface glycoprotein CD3 isoform CD3 eta
CD247/iso:CD3 eta
"A T-cell surface glycoprotein CD3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24161-2 or a 1:1 ortholog thereof." [PMID:2150596, PRO:CNA, PRO:DAN]

organism-sequence


PR:P24161-2
T-cell surface glycoprotein CD3 eta (mouse)
mCD247/iso:CD3 eta
"A T-cell surface glycoprotein CD3 isoform CD3 eta that is encoded in the genome of mouse." [PRO:DAN, UniProtKB:P24161]

modification


PR:000026667
T-cell surface glycoprotein CD3 isoform CD3 eta, signal peptide removed form
CD247/iso:CD3 eta/SigPep-
"A T-cell surface glycoprotein CD3 isoform CD3 eta that has had the signal peptide removed." [PRO:DNx]

sequence


PR:000001029
T-cell surface glycoprotein CD3 isoform CD3 zeta
CD247/iso:CD3 zeta
"A T-cell surface glycoprotein CD3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24161-1 or a 1:1 ortholog thereof." [PMID:2150596, PRO:CNA, PRO:DAN]

organism-sequence


PR:P20963-1
T-cell surface glycoprotein CD3 zeta chain (human)
hCD247/iso:CD3 zeta
"A T-cell surface glycoprotein CD3 isoform CD3 zeta that is encoded in the genome of human." [PRO:DNx, UniProtKB:P20963]

organism-modification


PR:000036628
T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 (human)
hCD247/iso:CD3 zeta/Phos:1
"A T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 in human." [PMID:9043947, PRO:CL]
Yes
organism-modification


PR:000061848
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed form (human)
hCD247/iso:CD3 zeta/SigPep-
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed. UniProtKB:P20963-1, 22-164." [PRO:DNx, Reactome:R-HSA-198166]

organism-modification


PR:000063475
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)
hCD247/iso:CD3 zeta/SigPep-/Phos:1
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]

organism-sequence


PR:P24161-1
T-cell surface glycoprotein CD3 zeta chain (mouse)
mCD247/iso:CD3 zeta
"A T-cell surface glycoprotein CD3 isoform CD3 zeta that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P24161]

modification


PR:000003061
T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated form
CD247/iso:CD3 zeta/PhosRes+
"A T-cell surface glycoprotein CD3 isoform CD3 zeta that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003062
T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1
CD247/iso:CD3 zeta/Phos:1
"A T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated form in which the phosphorylation occurs at the Tyr residues of the tyrosine-based activation motifs (TAMs, also known as Reth motifs), a 15-16 amino acid module containing two tyrosine residues." [PMID:2927501, PMID:7528772, PMID:8195151, PRO:CL]

organism-modification


PR:000036628
T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 (human)
hCD247/iso:CD3 zeta/Phos:1
"A T-cell surface glycoprotein CD3 isoform CD3 zeta phosphorylated 1 in human." [PMID:9043947, PRO:CL]
Yes
organism-modification


PR:000063475
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)
hCD247/iso:CD3 zeta/SigPep-/Phos:1
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]

modification


PR:000026560
T-cell surface glycoprotein CD3 isoform CD3 zeta, signal peptide removed form
CD247/iso:CD3 zeta/SigPep-
"A T-cell surface glycoprotein CD3 isoform CD3 zeta that has had the signal peptide removed." [PRO:DNx]

organism-modification


PR:000061848
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed form (human)
hCD247/iso:CD3 zeta/SigPep-
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed. UniProtKB:P20963-1, 22-164." [PRO:DNx, Reactome:R-HSA-198166]

organism-modification


PR:000063475
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)
hCD247/iso:CD3 zeta/SigPep-/Phos:1
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]

modification


PR:000018329
T-cell surface glycoprotein CD3, signal peptide removed form
CD247/SigPep-
"A T-cell surface glycoprotein CD3 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000026560
T-cell surface glycoprotein CD3 isoform CD3 zeta, signal peptide removed form
CD247/iso:CD3 zeta/SigPep-
"A T-cell surface glycoprotein CD3 isoform CD3 zeta that has had the signal peptide removed." [PRO:DNx]

organism-modification


PR:000061848
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed form (human)
hCD247/iso:CD3 zeta/SigPep-
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed. UniProtKB:P20963-1, 22-164." [PRO:DNx, Reactome:R-HSA-198166]

organism-modification


PR:000063475
T-cell surface glycoprotein CD3 zeta chain, signal peptide removed phosphorylated 1 (human)
hCD247/iso:CD3 zeta/SigPep-/Phos:1
"A T-cell surface glycoprotein CD3 zeta chain (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-72, Tyr-83, Tyr-111, Tyr-123, Tyr-142, and Tyr-153 of the amino acid sequence represented by UniProtKB:P20963-1. UniProtKB:P20963-1, 22-164, Tyr-72/Tyr-83/Tyr-111/Tyr-123/Tyr-142/Tyr-153, MOD:00048." [PRO:DNx, Reactome:R-HSA-202166]

modification


PR:000026667
T-cell surface glycoprotein CD3 isoform CD3 eta, signal peptide removed form
CD247/iso:CD3 eta/SigPep-
"A T-cell surface glycoprotein CD3 isoform CD3 eta that has had the signal peptide removed." [PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036628 hCD247/iso:CD3 zeta/Phos:1 acts_upstream_of_or_withinGO:0050852 T cell receptor signaling pathway PMID:9043947
located_inGO:0005886 plasma membrane PMID:9043947