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Protein Ontology report - integrin alpha-M
PR:000001012 - http://purl.obolibrary.org/obo/PR_000001012
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001012   
  PRO nameintegrin alpha-M 
  Synonyms
PRO-Short-label: EXACT:ITGAM
Gene-based: RELATED:CD11B | CR3A
Other: EXACT:CD11 antigen-like family member B | CD11b | cell surface glycoprotein MAC-1 subunit alpha | CR-3 alpha chain | leukocyte adhesion receptor MO1 | neutrophil adherence receptor
  Definition"An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." [UniProtKB:P11215] 
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000001005 integrin alpha with A domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2452
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001012 integrin alpha-M
ITGAM

organism-gene


PR:P05555 integrin alpha-M (mouse)
mITGAM

organism-sequence


PR:P05555-1 integrin alpha-M isoform m1 (mouse)
mITGAM/iso:m1

organism-sequence


PR:P05555-2 integrin alpha-M isoform m2 (mouse)
mITGAM/iso:m2

organism-gene


PR:P11215 integrin alpha-M (human)
hITGAM

organism-sequence


PR:P11215-1 integrin alpha-M isoform h1 (human)
hITGAM/iso:h1

organism-sequence


PR:P11215-2 integrin alpha-M isoform h2 (human)
hITGAM/iso:h2

organism-modification


PR:000027393 integrin alpha-M, signal peptide removed form (human)
hITGAM/SigPep-

Yes
organism-modification


PR:000065849 integrin alpha-M cysteinylated 1 (human)
hITGAM/Cyst:1

organism-modification


PR:000066531 integrin alpha-M deaminated 1 (human)
hITGAM/Deam:1

organism-modification


PR:000069121 integrin alpha-M deaminated 2 (human)
hITGAM/Deam:2

organism-modification


PR:000071155 integrin alpha-M deaminated 3 (human)
hITGAM/Deam:3

organism-modification


PR:000072678 integrin alpha-M deaminated 4 (human)
hITGAM/Deam:4

organism-modification


PR:000076367 integrin alpha-M deaminated 5 (human)
hITGAM/Deam:5

organism-modification


PR:000079184 integrin alpha-M cysteinylated 2 (human)
hITGAM/Cyst:2

organism-modification


PR:000081774 integrin alpha-M cysteinylated 3 (human)
hITGAM/Cyst:3

organism-gene


PR:Q9QYE7 integrin alpha-D (rat)
rITGAM

modification


PR:000018315 integrin alpha-M, signal peptide removed form
ITGAM/SigPep-

organism-modification


PR:000027393 integrin alpha-M, signal peptide removed form (human)
hITGAM/SigPep-

Yes
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ITGAM forms found in complexes   

ITGAM Component
 Complexes
PR:000027393 hITGAM/SigPep- PR:000027308 alphaM-beta2 integrin complex (human)
PR:000028431 integrin alphaMbeta2:JAM3 (human)