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Protein Ontology report - CD19 molecule
PR:000001002 - http://purl.obolibrary.org/obo/PR_000001002
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000001002   
  PRO nameCD19 molecule 
  Synonyms
PRO-Short-label: EXACT:CD19
Other: EXACT:B-lymphocyte surface antigen B4 | differentiation antigen CD19 | T-cell surface antigen Leu-12
  Definition"A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [PMID:15778510
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF016630;IUPHARobj:2764
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001002

CD19 molecule

CD19


"A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [PMID:15778510]


organism-gene



PR:P15391

B-lymphocyte antigen CD19 (human)

hCD19


"A CD19 molecule that is encoded in the genome of human." []


organism-sequence



PR:P15391-1

B-lymphocyte antigen CD19 isoform h1 (human)

hCD19/iso:h1


"A B-lymphocyte antigen CD19 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15391-1." [PRO:DNx, UniProtKB:P15391]


organism-sequence



PR:P15391-2

B-lymphocyte antigen CD19 isoform h2 (human)

hCD19/iso:h2


"A B-lymphocyte antigen CD19 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15391-2." [PRO:DNx, UniProtKB:P15391]


organism-modification



PR:000046612

B-lymphocyte antigen CD19, signal peptide removed form (human)

hCD19/SigPep-


"A B-lymphocyte antigen CD19 (human) that has had the signal peptide removed. UniProtKB:P15391, 20-556." [PRO:DNx, Reactome:R-HSA-197740]


organism-modification



PR:000046613

B-lymphocyte antigen CD19, signal peptide removed phosphorylated 1 (human)

hCD19/SigPep-/Phos:1


"A B-lymphocyte antigen CD19 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 348, 378, 409, 439, 500 and 531 of the amino acid sequence represented by UniProtKB:P15391. UniProtKB:P15391, 20-556, Tyr-348/Tyr-378/Tyr-409/Tyr-439/Tyr-500/Tyr-531, MOD:00048." [PRO:DNx, Reactome:R-HSA-2076270]


organism-modification



PR:000071967

B-lymphocyte antigen CD19 phosphorylated 1 (human)

hCD19/Phos:1


"A B-lymphocyte antigen CD19 (human) that has been phosphorylated on the residue at the position equivalent to Thr-47 of the amino acid sequence represented by UniProtKB:P15391-1. Example: UniProtKB:P15391-1, Thr-47, MOD:00047." [IEDB_epitope:2148449, PRO:DNx]


organism-modification



PR:000074187

B-lymphocyte antigen CD19 deaminated 1 (human)

hCD19/Deam:1


"A B-lymphocyte antigen CD19 (human) that has been deaminated on the residue at the position equivalent to Gln-519 of the amino acid sequence represented by UniProtKB:P15391-1. Example: UniProtKB:P15391-1, Gln-519, MOD:00685." [IEDB_epitope:1848031, PRO:DNx]


organism-modification



PR:000083147

B-lymphocyte antigen CD19 deaminated 2 (human)

hCD19/Deam:2


"A B-lymphocyte antigen CD19 (human) that has been deaminated on the residue at the position equivalent to Asn-86 of the amino acid sequence represented by UniProtKB:P15391-1. Example: UniProtKB:P15391-1, Asn-86, MOD:00684." [IEDB_epitope:1318398, PRO:DNx]


organism-gene



PR:P25918

B-lymphocyte antigen CD19 (mouse)

mCD19


"A CD19 molecule that is encoded in the genome of mouse." [OMA:P25918, PRO:DNx]


modification



PR:000018300

CD19 molecule, signal peptide removed form

CD19/SigPep-


"A CD19 molecule that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000046612

B-lymphocyte antigen CD19, signal peptide removed form (human)

hCD19/SigPep-


"A B-lymphocyte antigen CD19 (human) that has had the signal peptide removed. UniProtKB:P15391, 20-556." [PRO:DNx, Reactome:R-HSA-197740]


organism-modification



PR:000046613

B-lymphocyte antigen CD19, signal peptide removed phosphorylated 1 (human)

hCD19/SigPep-/Phos:1


"A B-lymphocyte antigen CD19 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 348, 378, 409, 439, 500 and 531 of the amino acid sequence represented by UniProtKB:P15391. UniProtKB:P15391, 20-556, Tyr-348/Tyr-378/Tyr-409/Tyr-439/Tyr-500/Tyr-531, MOD:00048." [PRO:DNx, Reactome:R-HSA-2076270]