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Protein Ontology report - voltage-gated potassium channel subunit KCNA2 isoform 1
PR:000000972 - http://purl.obolibrary.org/obo/PR_000000972
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000972   
  PRO namevoltage-gated potassium channel subunit KCNA2 isoform 1 
  Synonyms
PRO-Short-label: EXACT:KCNA2/iso:1
  Definition"A voltage-gated potassium channel subunit KCNA2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16389-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000810 voltage-gated potassium channel subunit KCNA2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000972

voltage-gated potassium channel subunit KCNA2 isoform 1

KCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16389-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P16389-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (human)

hKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

organism-sequence



PR:P63141-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (mouse)

mKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P63142-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (rat)

rKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000991

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form

KCNA2/iso:1/PhosRes+


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000001000

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1

KCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the REDEGYIK sequence located adjacent to the tetramerization domain. Phosphorylation at this site promotes endocytosis and suppresses the channel activity. Example: UniProtKB:P16389-1, Tyr-132, MOD:00048." [PRO:CNA]


organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

modification



PR:000001001

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2

KCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form in which the phosphorylation occurs at the pair of Ser residues within the SSPD motif at the C terminus. Phosphorylation at this site promotes cell surface localization. Example: UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term

Protein Forms & Complexes

Evidence
contributes_to GO:0005251 delayed rectifier potassium channel activityPR:P16389-1 hKCNA2/iso:1 PMID:1715584
NOT GO:0005251 delayed rectifier potassium channel activityPR:000036584 hKCNA2/iso:1/Phos:1 PMID:15215309
GO:0005515 protein bindingPR:P63142-1 rKCNA2/iso:1 PMID:17959782

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005768 endosomePR:000036584 hKCNA2/iso:1/Phos:1 PMID:15215309
GO:0008076 voltage-gated potassium channel complexPR:000036585 mKCNA2/iso:1/Phos:2 PMID:18056633
PR:000036586 rKCNA2/iso:1/Phos:2 PMID:18056633
PR:000036587 hKCNA2/iso:1/Phos:2 PMID:18056633
PR:P16389-1 hKCNA2/iso:1 PMID:2251283
GO:0009986 cell surfacePR:000036585 mKCNA2/iso:1/Phos:2 PMID:18056633
PR:000036586 rKCNA2/iso:1/Phos:2 PMID:18056633
PR:000036587 hKCNA2/iso:1/Phos:2 PMID:18056633
PR:P16389-1 hKCNA2/iso:1 PMID:15215309