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Protein Ontology report - A-type voltage-gated potassium channel KCND2
PR:000000785 - http://purl.obolibrary.org/obo/PR_000000785
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000785   
  PRO nameA-type voltage-gated potassium channel KCND2 
  Synonyms
PRO-Short-label: EXACT:KCND2
Gene-based: RELATED:KIAA1044
Other: EXACT:potassium voltage-gated channel subfamily D member 2 | voltage-gated potassium channel subunit Kv4.2
  Definition"A shal-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCND2 gene or a 1:1 ortholog thereof. Kv4.2 potassium channels play a critical role in postsynaptic excitability. They are modulated by phosphorylation as well as by association with Kv4 Channel Interacting Proteins (KChIPs). The N terminus contains an ER retention motif RKR that seems to be masked when associated to KChiPs. This masking increases surface expression." [PMID:12829703, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000710 shal-related voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:553
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000785

A-type voltage-gated potassium channel KCND2

KCND2


"A shal-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCND2 gene or a 1:1 ortholog thereof. Kv4.2 potassium channels play a critical role in postsynaptic excitability. They are modulated by phosphorylation as well as by association with Kv4 Channel Interacting Proteins (KChIPs). The N terminus contains an ER retention motif RKR that seems to be masked when associated to KChiPs. This masking increases surface expression." [PMID:12829703, PRO:CNA]


organism-gene



PR:Q5VSI1

A-type voltage-gated potassium channel KCND2 (zebrafish)

z-KCND2


"An A-type voltage-gated potassium channel KCND2 that is encoded in the genome of zebrafish." [PRO:CNA]


organism-gene



PR:Q9NZV8

A-type voltage-gated potassium channel KCND2 (human)

hKCND2


"An A-type voltage-gated potassium channel KCND2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NZV8]


organism-sequence



PR:Q9NZV8-1

A-type voltage-gated potassium channel KCND2 isoform 1 (human)

hKCND2/iso:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000084839

A-type voltage-gated potassium channel KCND2 deaminated 1 (human)

hKCND2/Deam:1


"An A-type voltage-gated potassium channel KCND2 (human) that has been deaminated on the residue at the position equivalent to Gln-554 of the amino acid sequence represented by UniProtKB:Q9NZV8. UniProtKB:Q9NZV8, Gln-554, MOD:00685." [IEDB_epitope:1823778, PRO:DNx]


organism-gene



PR:Q9Z0V2

A-type voltage-gated potassium channel KCND2 (mouse)

mKCND2


"An A-type voltage-gated potassium channel KCND2 that is encoded in the genome of mouse." [OMA:Q9Z0V2, PRO:DNx]


organism-sequence



PR:Q9Z0V2-1

A-type voltage-gated potassium channel KCND2 isoform 1 (mouse)

mKCND2/iso:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036577

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse)

mKCND2/iso:1/Phos:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047|Ser-552, MOD:00046." [PMID:10681507, PRO:CNA]


organism-modification



PR:000036578

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse)

mKCND2/iso:1/Phos:2


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047." [PMID:11040264, PRO:CNA]

Yes

organism-modification



PR:000036579

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse)

mKCND2/iso:1/Phos:3


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046." [PMID:11040264, PRO:CNA]

Yes

organism-modification



PR:000036580

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse)

mKCND2/iso:1/Phos:4


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 in mouse. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046." [PMID:11040264, PMID:16251476, PRO:CNA]

Yes

organism-modification



PR:000045389

A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse)

mKCND2/iso:1/UnPhos:3


"An A-type voltage-gated potassium channel KCND2 isoform 1 (mouse) that lacks phosphorylation on Ser-552. UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291." [PMID:12829703, PRO:CNA]

Yes

organism-modification



PR:000045390

A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse)

mKCND2/iso:1/UnPhos:4


"An A-type voltage-gated potassium channel KCND2 isoform 1 (mouse) that lacks phosphorylation on Thr-602, Thr-607, and Ser-616. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291." [PMID:16251476, PRO:CNA]

Yes

sequence



PR:000000947

A-type voltage-gated potassium channel KCND2 isoform 1

KCND2/iso:1


"An A-type voltage-gated potassium channel KCND2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZV8-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9NZV8-1

A-type voltage-gated potassium channel KCND2 isoform 1 (human)

hKCND2/iso:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9Z0V2-1

A-type voltage-gated potassium channel KCND2 isoform 1 (mouse)

mKCND2/iso:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036577

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse)

mKCND2/iso:1/Phos:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047|Ser-552, MOD:00046." [PMID:10681507, PRO:CNA]


organism-modification



PR:000036578

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse)

mKCND2/iso:1/Phos:2


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047." [PMID:11040264, PRO:CNA]

Yes

organism-modification



PR:000036579

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse)

mKCND2/iso:1/Phos:3


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046." [PMID:11040264, PRO:CNA]

Yes

organism-modification



PR:000036580

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse)

mKCND2/iso:1/Phos:4


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 in mouse. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046." [PMID:11040264, PMID:16251476, PRO:CNA]

Yes

organism-modification



PR:000045389

A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse)

mKCND2/iso:1/UnPhos:3


"An A-type voltage-gated potassium channel KCND2 isoform 1 (mouse) that lacks phosphorylation on Ser-552. UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291." [PMID:12829703, PRO:CNA]

Yes

organism-modification



PR:000045390

A-type voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse)

mKCND2/iso:1/UnPhos:4


"An A-type voltage-gated potassium channel KCND2 isoform 1 (mouse) that lacks phosphorylation on Thr-602, Thr-607, and Ser-616. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291." [PMID:16251476, PRO:CNA]

Yes

modification



PR:000000988

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated form

KCND2/iso:1/PhosRes+


"An A-type voltage-gated potassium channel KCND2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000994

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1

KCND2/iso:1/Phos:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the amino- and carboxyl-terminal cytoplasmic domains by cAMP-dependent protein kinase (PKA). At the N terminus, the phosporylation occurs at a Thr residue within the PKA consensus phosphorylation sequence adjacent to the first transmembrane domain (segment S1). At the C-terminus, it occurs at the conserved Ser within the motif [RQ]GS[IV]QEL. Example: UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047|Ser-552, MOD:00046." [PMID:10681507]


organism-modification



PR:000036577

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse)

mKCND2/iso:1/Phos:1


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047|Ser-552, MOD:00046." [PMID:10681507, PRO:CNA]


modification



PR:000000995

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2

KCND2/iso:1/Phos:2


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the amino-terminal cytoplasmic domain by cAMP-dependent protein kinase (PKA). The phosporylation occurs at a Thr residue within the PKA consensus phosphorylation sequence adjacent to the first transmembrane domain (segment S1). Example: UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047." [PMID:11040264]


organism-modification



PR:000036578

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse)

mKCND2/iso:1/Phos:2


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047." [PMID:11040264, PRO:CNA]

Yes

modification



PR:000000996

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3

KCND2/iso:1/Phos:3


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the carboxyl-terminal cytoplasmic domain by cAMP-dependent protein kinase (PKA). Phosphorylation occurs at the conserved Ser within the motif [RQ]GS[IV]QEL. Example: UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046." [PRO:CNA]


organism-modification



PR:000036579

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse)

mKCND2/iso:1/Phos:3


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046." [PMID:11040264, PRO:CNA]

Yes

modification



PR:000000997

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4

KCND2/iso:1/Phos:4


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the carboxyl-terminal cytoplasmic domain by ERK at the three most C-terminal consensus motifs (minimal motif=a Ser or Thr followed directly by a proline). Example: UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046." [PMID:11080179]


organism-modification



PR:000036580

A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse)

mKCND2/iso:1/Phos:4


"An A-type voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 in mouse. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046." [PMID:11040264, PMID:16251476, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036578 mKCND2/iso:1/Phos:2
UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047
located_inGO:0030425 dendrite PMID:11040264
PR:000036579 mKCND2/iso:1/Phos:3
UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046
located_inGO:0030425 dendrite PMID:11040264
PR:000036580 mKCND2/iso:1/Phos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046
enablesdecreased|contributes_to GO:0005250 A-type (transient outward) potassium channel activity relative to PR:000002656 PMID:16251476
located_inGO:0009986 cell surface PMID:16251476
GO:0030425 dendrite PMID:11040264
PR:000045389 mKCND2/iso:1/UnPhos:3
UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291
located_inGO:0009986 cell surface PMID:12829703; PMID:16251476
PR:000045390 mKCND2/iso:1/UnPhos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291
enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:16251476
PR:Q9NZV8-1 hKCND2/iso:1 acts_upstream_of_or_withinGO:0001508 action potential PMID:11102480
GO:0007268 chemical synaptic transmission PMID:11102480
located_inGO:0009986 cell surface PMID:12493773
PR:Q9Z0V2-1 mKCND2/iso:1 located_inGO:0005783 endoplasmic reticulum PMID:12829703