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Protein Ontology report - voltage-gated potassium channel KCNC4
PR:000000783 - http://purl.obolibrary.org/obo/PR_000000783
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000783   
  PRO namevoltage-gated potassium channel KCNC4 
  Synonyms
PRO-Short-label: EXACT:KCNC4
Gene-based: RELATED:C1orf30
Other: EXACT:KSHIIIC | potassium voltage-gated channel subfamily C member 4 | voltage-gated potassium channel subunit Kv3.4
  Definition"A shaw-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNC4 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000711 shaw-related voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:551
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000783

voltage-gated potassium channel KCNC4

KCNC4


"A shaw-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNC4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:E1C3U8

uncharacterized protein, KCNC4 translation product (chicken)

chick-KCNC4


"A voltage-gated potassium channel KCNC4 that is encoded in the genome of chicken." [OMA:E1C3U8, PRO:CNA]


organism-gene



PR:Q03721

voltage-gated potassium channel KCNC4 (human)

hKCNC4


"A voltage-gated potassium channel KCNC4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q03721]


organism-sequence



PR:Q03721-1

voltage-gated potassium channel KCNC4 isoform 1 (human)

hKCNC4/iso:1


"A voltage-gated potassium channel KCNC4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q03721-2

voltage-gated potassium channel KCNC4 isoform 2 (human)

hKCNC4/iso:2


"A voltage-gated potassium channel KCNC4 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q03721]


organism-modification



PR:000036576

voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 (human)

hKCNC4/iso:2/Phos:1


"A voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 in human. UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, MOD:00046." [PMID:7993631, PMID:9649584, PRO:CNA]

Yes

organism-modification



PR:000045387

voltage-gated potassium channel KCNC4 isoform 2 unphosphorylated 1 (human)

hKCNC4/iso:2/UnPhos:1


"A voltage-gated potassium channel KCNC4 isoform 2 (human) that lacks phosphorylation on Ser-8, Ser-9, Ser-15 and Ser-21. UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, PR:000026291." [PMID:7993631, PMID:9649584, PRO:CNA]

Yes

organism-sequence



PR:Q03721-3

voltage-gated potassium channel KCNC4 isoform h3 (human)

hKCNC4/iso:h3


"A voltage-gated potassium channel KCNC4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03721-3." [PRO:DNx, UniProtKB:Q03721]


organism-gene



PR:Q63734

voltage-gated potassium channel KCNC4 (rat)

rKCNC4


"A voltage-gated potassium channel KCNC4 that is encoded in the genome of rat." [OMA:Q63734, PRO:DNx]


organism-gene



PR:Q8R1C0

voltage-gated potassium channel KCNC4 (mouse)

mKCNC4


"A voltage-gated potassium channel KCNC4 that is encoded in the genome of mouse." [OMA:Q8R1C0, PRO:DNx]


sequence



PR:000000945

voltage-gated potassium channel KCNC4 isoform 1

KCNC4/iso:1


"A voltage-gated potassium channel KCNC4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03721-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q03721-1

voltage-gated potassium channel KCNC4 isoform 1 (human)

hKCNC4/iso:1


"A voltage-gated potassium channel KCNC4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000946

voltage-gated potassium channel KCNC4 isoform 2

KCNC4/iso:2


"A voltage-gated potassium channel KCNC4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03721-2 or a 1:1 ortholog thereof." [PMID:1381835, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q03721-2

voltage-gated potassium channel KCNC4 isoform 2 (human)

hKCNC4/iso:2


"A voltage-gated potassium channel KCNC4 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q03721]


organism-modification



PR:000036576

voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 (human)

hKCNC4/iso:2/Phos:1


"A voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 in human. UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, MOD:00046." [PMID:7993631, PMID:9649584, PRO:CNA]

Yes

organism-modification



PR:000045387

voltage-gated potassium channel KCNC4 isoform 2 unphosphorylated 1 (human)

hKCNC4/iso:2/UnPhos:1


"A voltage-gated potassium channel KCNC4 isoform 2 (human) that lacks phosphorylation on Ser-8, Ser-9, Ser-15 and Ser-21. UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, PR:000026291." [PMID:7993631, PMID:9649584, PRO:CNA]

Yes

modification



PR:000000987

voltage-gated potassium channel KCNC4 isoform 2 phosphorylated form

KCNC4/iso:2/PhosRes+


"A voltage-gated potassium channel KCNC4 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000993

voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1

KCNC4/iso:2/Phos:1


"A voltage-gated potassium channel KCNC4 isoform 2 phosphorylated form in which the phosphorylation occurs by the action of PKC at multiple Ser residues located in the N-terminal domain. Example: UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, MOD:00046." [PRO:CNA]


organism-modification



PR:000036576

voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 (human)

hKCNC4/iso:2/Phos:1


"A voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 in human. UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, MOD:00046." [PMID:7993631, PMID:9649584, PRO:CNA]

Yes

modification



PR:000002655

voltage-gated potassium channel KCNC4 isoform 2 unmodified form

KCNC4/iso:2/UnMod


"A voltage-gated potassium channel KCNC4 isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036576 hKCNC4/iso:2/Phos:1
UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, MOD:00046
enablesdecreased|contributes_to GO:0005250 A-type (transient outward) potassium channel activity relative to PR:000002655 KCNC4/iso:2/UnMod PMID:7993631; PMID:9649584
PR:000045387 hKCNC4/iso:2/UnPhos:1
UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, PR:000026291
enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:1381835; PMID:7993631; PMID:9649584