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Protein Ontology report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
PR:000000708 - http://purl.obolibrary.org/obo/PR_000000708
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000708   
  PRO namepotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 
  Synonyms
PRO-Short-label: EXACT:HCN4
Gene-based: RELATED:Bcng3
Other: EXACT:BCNG-3 | brain cyclic nucleotide-gated channel 3
  Definition"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN4 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000676 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500963;IUPHARobj:403
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000708 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
HCN4

organism-gene


PR:O70507 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (mouse)
mHCN4

organism-modification


PR:000029936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
mHCN4/Phos:1

organism-gene


PR:Q9JKA7 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rat)
rHCN4

organism-gene


PR:Q9TV66 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit)
rabbit-HCN4

organism-sequence


PR:Q9TV66-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform r1 (rabbit)
rabbit-HCN4/iso:r1
Yes
organism-gene


PR:Q9Y3Q4 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
hHCN4

organism-sequence


PR:000000759 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human)
hHCN4/var:D553N
Yes
organism-sequence


PR:000000760 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)
hHCN4/var:S672R
Yes
organism-sequence


PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
hHCN4/iso:1
Yes
sequence


PR:000000758 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1
HCN4/iso:1

organism-sequence


PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
hHCN4/iso:1
Yes
modification


PR:000002604 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 unmodified form
HCN4/iso:1/UnMod

modification


PR:000029935 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1
HCN4/Phos:1

organism-modification


PR:000029936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
mHCN4/Phos:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006812 monoatomic cation transportPR:Q9Y3Q4-1 hHCN4/iso:1 PMID:10228147
GO:0006936 muscle contractionPR:Q9Y3Q4-1 hHCN4/iso:1 PMID:10228147

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:13884 sick sinus syndromePR:000000759 hHCN4/var:D553N PMID:15123648
PR:000000760 hHCN4/var:S672R PMID:16407510

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005222 intracellularly cAMP-activated cation channel activityPR:000000760 hHCN4/var:S672R PMID:16407510
GO:0005261 monoatomic cation channel activityPR:Q9Y3Q4-1 hHCN4/iso:1 PMID:10228147
GO:0022843 voltage-gated monoatomic cation channel activityPR:000000760 hHCN4/var:S672R PMID:16407510

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:Q9TV66-1 rabbit-HCN4/iso:r1 PMID:15123648
NOT GO:0005886 plasma membranePR:000000759 hHCN4/var:D553N PMID:15123648