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Protein Ontology report - intermediate conductance calcium-activated potassium channel protein 4
PR:000000700 - http://purl.obolibrary.org/obo/PR_000000700
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000700   
  PRO nameintermediate conductance calcium-activated potassium channel protein 4 
  Synonyms
PRO-Short-label: EXACT:KCNN4
Gene-based: RELATED:IK1 | IKCA1 | KCA4 | SK4
Other: EXACT:IKCa1 | KCa3.1 | KCa4 | putative Gardos channel | SKCa 4 | SKCa4
  Definition"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels." [PMID:9326665, PMID:9407042] 
  PRO Categorygene 
  ParentPR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:384
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
KCNN4

organism-gene


PR:O15554 intermediate conductance calcium-activated potassium channel protein 4 (human)
hKCNN4
Yes
organism-sequence


PR:O15554-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
hKCNN4/iso:1
Yes
organism-modification


PR:000071778 intermediate conductance calcium-activated potassium channel protein 4 deaminated 1 (human)
hKCNN4/Deam:1

organism-gene


PR:O89109 intermediate conductance calcium-activated potassium channel protein 4 (mouse)
mKCNN4

organism-sequence


PR:O89109-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
mKCNN4/iso:1
Yes
organism-gene


PR:Q9QYW1 intermediate conductance calcium-activated potassium channel protein 4 (rat)
rKCNN4

sequence


PR:000000753 intermediate conductance calcium-activated potassium channel protein 4 isoform 1
KCNN4/iso:1

organism-sequence


PR:O15554-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
hKCNN4/iso:1
Yes
organism-sequence


PR:O89109-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
mKCNN4/iso:1
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006952 defense responsePR:O15554 hKCNN4 PMID:11278890; PMID:9407042
GO:0050714 positive regulation of protein secretionPR:O89109-1 mKCNN4/iso:1 PMID:11724775

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005516 calmodulin bindingPR:O15554 hKCNN4 PMID:10026195
PR:O15554-1 hKCNN4/iso:1 PMID:10026195
GO:0015269 calcium-activated potassium channel activityPR:O89109-1 mKCNN4/iso:1 PMID:11724775

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0009986 cell surfacePR:O15554-1 hKCNN4/iso:1 PMID:11395478