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Protein Ontology report - intermediate conductance calcium-activated potassium channel protein 4
PR:000000700 - http://purl.obolibrary.org/obo/PR_000000700
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000700   
  PRO nameintermediate conductance calcium-activated potassium channel protein 4 
  Synonyms
PRO-Short-label: EXACT:KCNN4
Gene-based: RELATED:IK1 | IKCA1 | KCA4 | SK4
Other: EXACT:IKCa1 | KCa3.1 | KCa4 | putative Gardos channel | SKCa 4 | SKCa4
  Definition"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels." [PMID:9326665, PMID:9407042
  PRO Categorygene 
  ParentPR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:384
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000700

intermediate conductance calcium-activated potassium channel protein 4

KCNN4


"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels." [PMID:9326665, PMID:9407042]


organism-gene



PR:O15554

intermediate conductance calcium-activated potassium channel protein 4 (human)

hKCNN4


"An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human." []

Yes

organism-sequence



PR:O15554-1

intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)

hKCNN4/iso:1


"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000071778

intermediate conductance calcium-activated potassium channel protein 4 deaminated 1 (human)

hKCNN4/Deam:1


"An intermediate conductance calcium-activated potassium channel protein 4 (human) that has been deaminated on the residue at the position equivalent to Gln-382 of the amino acid sequence represented by UniProtKB:O15554. UniProtKB:O15554, Gln-382, MOD:00685." [IEDB_epitope:1731235, PRO:DNx]


organism-gene



PR:O89109

intermediate conductance calcium-activated potassium channel protein 4 (mouse)

mKCNN4


"An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of mouse." [OMA:O89109, PRO:DNx]


organism-sequence



PR:O89109-1

intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)

mKCNN4/iso:1


"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:Q9QYW1

intermediate conductance calcium-activated potassium channel protein 4 (rat)

rKCNN4


"An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of rat." [OMA:Q9QYW1, PRO:DNx]


sequence



PR:000000753

intermediate conductance calcium-activated potassium channel protein 4 isoform 1

KCNN4/iso:1


"An intermediate conductance calcium-activated potassium channel protein 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15554-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O15554-1

intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)

hKCNN4/iso:1


"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O89109-1

intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)

mKCNN4/iso:1


"An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006952 defense responsePR:O15554 hKCNN4 PMID:11278890; PMID:9407042
GO:0050714 positive regulation of protein secretionPR:O89109-1 mKCNN4/iso:1 PMID:11724775

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005516 calmodulin bindingPR:O15554 hKCNN4 PMID:10026195
PR:O15554-1 hKCNN4/iso:1 PMID:10026195
GO:0015269 calcium-activated potassium channel activityPR:O89109-1 mKCNN4/iso:1 PMID:11724775

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0009986 cell surfacePR:O15554-1 hKCNN4/iso:1 PMID:11395478