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Protein Ontology report - cyclic nucleotide-gated channel beta-3
PR:000000697 - http://purl.obolibrary.org/obo/PR_000000697
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000697   
  PRO namecyclic nucleotide-gated channel beta-3 
  Synonyms
PRO-Short-label: EXACT:CNGB3
Gene-based: RELATED:Cng6
Other: EXACT:CNG channel beta-3 | cone photoreceptor cGMP-gated channel subunit beta | cyclic nucleotide-gated cation channel beta-3 | cyclic nucleotide-gated channel subunit CNG6
  Definition"A cyclic nucleotide-gated channel beta subunit that is a translation product of the human CNGB3 gene or a 1:1 ortholog thereof. Many members of this class are subunits of the cone cyclic nucleotide-gated cation channel, which generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000674 cyclic nucleotide-gated channel beta subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence3                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF501006;IUPHARobj:399
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000697 cyclic nucleotide-gated channel beta-3
CNGB3

organism-gene


PR:Q9JJZ9 cyclic nucleotide-gated channel beta-3 (mouse)
mCNGB3

organism-sequence


PR:Q9JJZ9-1 cyclic nucleotide-gated channel beta-3 isoform 1 (mouse)
mCNGB3/iso:1
Yes
organism-gene


PR:Q9NQW8 cyclic nucleotide-gated channel beta-3 (human)
hCNGB3

organism-sequence


PR:000000752 cyclic nucleotide-gated channel beta-3 sequence variant S435F (human)
hCNGB3/var:S435F
Yes
organism-sequence


PR:Q9NQW8-1 cyclic nucleotide-gated channel beta-3 isoform 1 (human)
hCNGB3/iso:1

organism-sequence


PR:Q9NQW8-2 cyclic nucleotide-gated channel beta-3 isoform 2 (human)
hCNGB3/iso:2

sequence


PR:000000749 cyclic nucleotide-gated channel beta-3 isoform 1
CNGB3/iso:1

organism-sequence


PR:Q9JJZ9-1 cyclic nucleotide-gated channel beta-3 isoform 1 (mouse)
mCNGB3/iso:1
Yes
sequence


PR:000000750 cyclic nucleotide-gated channel beta-3 isoform 2
CNGB3/iso:2

organism-sequence


PR:Q9NQW8-2 cyclic nucleotide-gated channel beta-3 isoform 2 (human)
hCNGB3/iso:2

sequence


PR:000000751 cyclic nucleotide-gated channel beta-3 isoform 3
CNGB3/iso:3

organism-sequence


PR:Q9NQW8-1 cyclic nucleotide-gated channel beta-3 isoform 1 (human)
hCNGB3/iso:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:13911 achromatopsiaPR:000000752 hCNGB3/var:S435F PMID:10888875; PMID:10958649

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005223 intracellularly cGMP-activated cation channel activityPR:Q9JJZ9-1 mCNGB3/iso:1 PMID:10662822
GO:0005515 protein bindingPR:Q9JJZ9-1 mCNGB3/iso:1 PMID:10662822

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0001750 photoreceptor outer segmentPR:Q9JJZ9-1 mCNGB3/iso:1 PMID:15634774
GO:0005886 plasma membranePR:Q9JJZ9-1 mCNGB3/iso:1 PMID:10662822