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Protein Ontology report - voltage-gated potassium channel subunit KQT
PR:000000684 - http://purl.obolibrary.org/obo/PR_000000684
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000684   
  PRO namevoltage-gated potassium channel subunit KQT 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_sub-KQT
  Definition"A voltage-gated potassium channel protein that has a core domain composition consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. The charged S4 segment with a basic amino acid at every third position confers their voltage sensitivity. Unlike other voltage-gated potassium channels, these proteins lack the N-terminal tetramerization domain (T1), which encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Also, unique to this class is the presence of a carboxyl-terminal domain called the KCNQ voltage-gated potassium channel domain (Pfam:PF03520) or A-domain. Voltage-gated potassium channels are composed of tetramers of alpha subunits, with each alpha subunit containing a voltage sensor and contributing to the central pore. This pore is formed by these subunits that encircle a central ion conduction pathway. KQT channels are responsible for M-type potassium currents in the nervous and auditory systems and slow delayed rectifier K+ currents in the heart." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000044654 voltage-gated potassium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene5                                                  Organism-Gene 13                                        
         Sequence25                                                  Organism-Sequence 137                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038513
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000684 voltage-gated potassium channel subunit KQT
fam:Kchan_sub-KQT
Yes
gene


PR:000000728 voltage-gated potassium channel subunit KCNQ1
KCNQ1

organism-gene


PR:P51787 potassium voltage-gated channel subfamily KQT member 1 (human)
hKCNQ1

organism-sequence


PR:000000817 voltage-gated potassium channel subunit KCNQ1 sequence variant T587M (human)
hKCNQ1/var:T587M
Yes
organism-sequence


PR:000000818 voltage-gated potassium channel subunit KCNQ1 sequence variant S373P (human)
hKCNQ1/var:S373P
Yes
organism-sequence


PR:000000819 voltage-gated potassium channel subunit KCNQ1 sequence variant R243C (human)
hKCNQ1/var:R243C
Yes
organism-sequence


PR:000000820 voltage-gated potassium channel subunit KCNQ1 sequence variant D317N (human)
hKCNQ1/var:D317N
Yes
organism-sequence


PR:000000821 voltage-gated potassium channel subunit KCNQ1 sequence variant V310I (human)
hKCNQ1/var:V310I
Yes
organism-sequence


PR:000000822 voltage-gated potassium channel subunit KCNQ1 sequence variant S566F (human)
hKCNQ1/var:S566F
Yes
organism-sequence


PR:000000823 voltage-gated potassium channel subunit KCNQ1 sequence variant Y315C (human)
hKCNQ1/var:Y315C
Yes
organism-sequence


PR:000000824 voltage-gated potassium channel subunit KCNQ1 sequence variant S225L (human)
hKCNQ1/var:S225L
Yes
organism-sequence


PR:000000825 voltage-gated potassium channel subunit KCNQ1 sequence variant A178P (human)
hKCNQ1/var:A178P
Yes
organism-sequence


PR:000000826 voltage-gated potassium channel subunit KCNQ1 sequence variant A178T (human)
hKCNQ1/var:A178T
Yes
organism-sequence


PR:000000827 voltage-gated potassium channel subunit KCNQ1 sequence variant G189R (human)
hKCNQ1/var:G189R
Yes
organism-sequence


PR:000000828 voltage-gated potassium channel subunit KCNQ1 sequence variant P448R (human)
hKCNQ1/var:P448R
Yes
organism-sequence


PR:000000829 voltage-gated potassium channel subunit KCNQ1 sequence variant T309R (human)
hKCNQ1/var:T309R
Yes
organism-sequence


PR:000000830 voltage-gated potassium channel subunit KCNQ1 sequence variant R591H (human)
hKCNQ1/var:R591H
Yes
organism-sequence


PR:000000831 voltage-gated potassium channel subunit KCNQ1 sequence variant R366W (human)
hKCNQ1/var:R366W
Yes
organism-sequence


PR:000000832 voltage-gated potassium channel subunit KCNQ1 sequence variant I313M (human)
hKCNQ1/var:I313M
Yes
organism-sequence


PR:000000833 voltage-gated potassium channel subunit KCNQ1 sequence variant Y111C (human)
hKCNQ1/var:Y111C
Yes
organism-sequence


PR:000000834 voltage-gated potassium channel subunit KCNQ1 sequence variant R533W (human)
hKCNQ1/var:R533W
Yes
organism-sequence


PR:000000835 voltage-gated potassium channel subunit KCNQ1 sequence variant G168R (human)
hKCNQ1/var:G168R
Yes
organism-sequence


PR:000000836 voltage-gated potassium channel subunit KCNQ1 sequence variant E261D (human)
hKCNQ1/var:E261D
Yes
organism-sequence


PR:000000837 voltage-gated potassium channel subunit KCNQ1 sequence variant A371T (human)
hKCNQ1/var:A371T
Yes
organism-sequence


PR:000000838 voltage-gated potassium channel subunit KCNQ1 sequence variant 29 (human)
hKCNQ1/var:29
Yes
organism-sequence


PR:000000839 voltage-gated potassium channel subunit KCNQ1 sequence variant A341V (human)
hKCNQ1/var:A341V
Yes
organism-sequence


PR:000000840 voltage-gated potassium channel subunit KCNQ1 sequence variant L250H (human)
hKCNQ1/var:L250H
Yes
organism-sequence


PR:000000841 voltage-gated potassium channel subunit KCNQ1 sequence variant S349W (human)
hKCNQ1/var:S349W
Yes
organism-sequence


PR:000000842 voltage-gated potassium channel subunit KCNQ1 sequence variant T391I (human)
hKCNQ1/var:T391I
Yes
organism-sequence


PR:000000843 voltage-gated potassium channel subunit KCNQ1 sequence variant K318N (human)
hKCNQ1/var:K318N
Yes
organism-sequence


PR:000000844 voltage-gated potassium channel subunit KCNQ1 sequence variant A344V (human)
hKCNQ1/var:A344V
Yes
organism-sequence


PR:000000845 voltage-gated potassium channel subunit KCNQ1 sequence variant A525T (human)
hKCNQ1/var:A525T
Yes
organism-sequence


PR:000000846 voltage-gated potassium channel subunit KCNQ1 sequence variant A341E (human)
hKCNQ1/var:A341E
Yes
organism-sequence


PR:000000847 voltage-gated potassium channel subunit KCNQ1 sequence variant R583C (human)
hKCNQ1/var:R583C
Yes
organism-sequence


PR:000000848 voltage-gated potassium channel subunit KCNQ1 sequence variant D242N (human)
hKCNQ1/var:D242N
Yes
organism-sequence


PR:000000849 voltage-gated potassium channel subunit KCNQ1 sequence variant L342F (human)
hKCNQ1/var:L342F
Yes
organism-sequence


PR:000000850 voltage-gated potassium channel subunit KCNQ1 sequence variant G306R (human)
hKCNQ1/var:G306R
Yes
organism-sequence


PR:000000851 voltage-gated potassium channel subunit KCNQ1 sequence variant S140G (human)
hKCNQ1/var:S140G
Yes
organism-sequence


PR:000000852 voltage-gated potassium channel subunit KCNQ1 sequence variant G269S (human)
hKCNQ1/var:G269S
Yes
organism-sequence


PR:000000853 voltage-gated potassium channel subunit KCNQ1 sequence variant R555C (human)
hKCNQ1/var:R555C
Yes
organism-sequence


PR:000000854 voltage-gated potassium channel subunit KCNQ1 sequence variant R539W (human)
hKCNQ1/var:R539W
Yes
organism-sequence


PR:000000855 voltage-gated potassium channel subunit KCNQ1 sequence variant Y315S (human)
hKCNQ1/var:Y315S
Yes
organism-sequence


PR:000000856 voltage-gated potassium channel subunit KCNQ1 sequence variant R174H (human)
hKCNQ1/var:R174H
Yes
organism-sequence


PR:000000857 voltage-gated potassium channel subunit KCNQ1 sequence variant A194P (human)
hKCNQ1/var:A194P
Yes
organism-sequence


PR:000000858 voltage-gated potassium channel subunit KCNQ1 sequence variant Y184S (human)
hKCNQ1/var:Y184S
Yes
organism-sequence


PR:000000859 voltage-gated potassium channel subunit KCNQ1 sequence variant G345E (human)
hKCNQ1/var:G345E
Yes
organism-sequence


PR:000000860 voltage-gated potassium channel subunit KCNQ1 sequence variant R190Q (human)
hKCNQ1/var:R190Q
Yes
organism-sequence


PR:000000861 voltage-gated potassium channel subunit KCNQ1 sequence variant T311I (human)
hKCNQ1/var:T311I
Yes
organism-sequence


PR:000000862 voltage-gated potassium channel subunit KCNQ1 sequence variant G314S (human)
hKCNQ1/var:G314S
Yes
organism-sequence


PR:000000863 voltage-gated potassium channel subunit KCNQ1 sequence variant W248R (human)
hKCNQ1/var:W248R
Yes
organism-sequence


PR:000000864 voltage-gated potassium channel subunit KCNQ1 sequence variant R366P (human)
hKCNQ1/var:R366P
Yes
organism-sequence


PR:000000865 voltage-gated potassium channel subunit KCNQ1 sequence variant R366Q (human)
hKCNQ1/var:R366Q
Yes
organism-sequence


PR:000000866 voltage-gated potassium channel subunit KCNQ1 sequence variant E160K (human)
hKCNQ1/var:E160K
Yes
organism-sequence


PR:000000867 voltage-gated potassium channel subunit KCNQ1 sequence variant V254M (human)
hKCNQ1/var:V254M
Yes
organism-sequence


PR:000000868 voltage-gated potassium channel subunit KCNQ1 sequence variant G345R (human)
hKCNQ1/var:G345R
Yes
organism-sequence


PR:000000869 voltage-gated potassium channel subunit KCNQ1 sequence variant E261K (human)
hKCNQ1/var:E261K
Yes
organism-sequence


PR:000000870 voltage-gated potassium channel subunit KCNQ1 sequence variant V307L (human)
hKCNQ1/var:V307L
Yes
organism-sequence


PR:000000871 voltage-gated potassium channel subunit KCNQ1 sequence variant F339del (human)
hKCNQ1/var:F339del
Yes
organism-sequence


PR:000000872 voltage-gated potassium channel subunit KCNQ1 sequence variant R243H (human)
hKCNQ1/var:R243H
Yes
organism-sequence


PR:000000873 voltage-gated potassium channel subunit KCNQ1 sequence variant G179S (human)
hKCNQ1/var:G179S
Yes
organism-sequence


PR:000000874 voltage-gated potassium channel subunit KCNQ1 sequence variant A300T (human)
hKCNQ1/var:A300T
Yes
organism-sequence


PR:000000875 voltage-gated potassium channel subunit KCNQ1 sequence variant R174C (human)
hKCNQ1/var:R174C
Yes
organism-sequence


PR:000000876 voltage-gated potassium channel subunit KCNQ1 sequence variant W305S (human)
hKCNQ1/var:W305S
Yes
organism-sequence


PR:000000877 voltage-gated potassium channel subunit KCNQ1 sequence variant L266P (human)
hKCNQ1/var:L266P
Yes
organism-sequence


PR:000000878 voltage-gated potassium channel subunit KCNQ1 sequence variant R594Q (human)
hKCNQ1/var:R594Q
Yes
organism-sequence


PR:000000879 voltage-gated potassium channel subunit KCNQ1 sequence variant L273F (human)
hKCNQ1/var:L273F
Yes
organism-sequence


PR:000000880 voltage-gated potassium channel subunit KCNQ1 sequence variant Y281C (human)
hKCNQ1/var:Y281C
Yes
organism-sequence


PR:000000881 voltage-gated potassium channel subunit KCNQ1 sequence variant P320A (human)
hKCNQ1/var:P320A
Yes
organism-sequence


PR:000000882 voltage-gated potassium channel subunit KCNQ1 sequence variant F157C (human)
hKCNQ1/var:F157C
Yes
organism-sequence


PR:000000883 voltage-gated potassium channel subunit KCNQ1 sequence variant L353P (human)
hKCNQ1/var:L353P
Yes
organism-sequence


PR:000000884 voltage-gated potassium channel subunit KCNQ1 sequence variant G325R (human)
hKCNQ1/var:G325R
Yes
organism-sequence


PR:000000885 voltage-gated potassium channel subunit KCNQ1 sequence variant W392R (human)
hKCNQ1/var:W392R
Yes
organism-sequence


PR:000000886 voltage-gated potassium channel subunit KCNQ1 sequence variant G269D (human)
hKCNQ1/var:G269D
Yes
organism-sequence


PR:000000887 voltage-gated potassium channel subunit KCNQ1 sequence variant G589D (human)
hKCNQ1/var:G589D
Yes
organism-sequence


PR:000000888 voltage-gated potassium channel subunit KCNQ1 sequence variant G216R (human)
hKCNQ1/var:G216R
Yes
organism-sequence


PR:000000889 voltage-gated potassium channel subunit KCNQ1 sequence variant V417M (human)
hKCNQ1/var:V417M
Yes
organism-sequence


PR:000000890 voltage-gated potassium channel subunit KCNQ1 sequence variant T312I (human)
hKCNQ1/var:T312I
Yes
organism-sequence


PR:P51787-1 potassium voltage-gated channel subfamily KQT member 1 isoform 1 (human)
hKCNQ1/iso:1
Yes
organism-sequence


PR:P51787-2 potassium voltage-gated channel subfamily KQT member 1 isoform 2 (human)
hKCNQ1/iso:2
Yes
organism-gene


PR:P97414 potassium voltage-gated channel subfamily KQT member 1 (mouse)
mKCNQ1

organism-sequence


PR:P97414-1 potassium voltage-gated channel subfamily KQT member 1 isoform I (mouse)
mKCNQ1/iso:I

organism-sequence


PR:P97414-2 potassium voltage-gated channel subfamily KQT member 1 isoform II (mouse)
mKCNQ1/iso:II

organism-gene


PR:Q9Z0N7 potassium voltage-gated channel subfamily KQT member 1 (rat)
rKCNQ1

sequence


PR:000000815 voltage-gated potassium channel subunit KCNQ1 isoform 1
KCNQ1/iso:1

organism-sequence


PR:P51787-1 potassium voltage-gated channel subfamily KQT member 1 isoform 1 (human)
hKCNQ1/iso:1
Yes
modification


PR:000002622 voltage-gated potassium channel subunit KCNQ1 isoform 1 unmodified form
KCNQ1/iso:1/UnMod

sequence


PR:000000816 voltage-gated potassium channel subunit KCNQ1 isoform 2
KCNQ1/iso:2

organism-sequence


PR:P51787-2 potassium voltage-gated channel subfamily KQT member 1 isoform 2 (human)
hKCNQ1/iso:2
Yes
gene


PR:000000729 voltage-gated potassium channel subunit KCNQ2
KCNQ2

organism-gene


PR:O43526 potassium voltage-gated channel subfamily KQT member 2 (human)
hKCNQ2

organism-sequence


PR:000000907 voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human)
hKCNQ2/var:S247W
Yes
organism-sequence


PR:000000908 voltage-gated potassium channel subunit KCNQ2 sequence variant H228Q (human)
hKCNQ2/var:H228Q
Yes
organism-sequence


PR:000000909 voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human)
hKCNQ2/var:R207W
Yes
organism-sequence


PR:000000910 voltage-gated potassium channel subunit KCNQ2 sequence variant L243F (human)
hKCNQ2/var:L243F
Yes
organism-sequence


PR:000000911 voltage-gated potassium channel subunit KCNQ2 sequence variant 4 (human)
hKCNQ2/var:4
Yes
organism-sequence


PR:000000912 voltage-gated potassium channel subunit KCNQ2 sequence variant Y284C (human)
hKCNQ2/var:Y284C
Yes
organism-sequence


PR:000000913 voltage-gated potassium channel subunit KCNQ2 sequence variant A306T (human)
hKCNQ2/var:A306T
Yes
organism-sequence


PR:000000914 voltage-gated potassium channel subunit KCNQ2 sequence variant R333Q (human)
hKCNQ2/var:R333Q
Yes
organism-sequence


PR:000000915 voltage-gated potassium channel subunit KCNQ2 sequence variant M208V (human)
hKCNQ2/var:M208V
Yes
organism-sequence


PR:O43526-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)
hKCNQ2/iso:1

organism-sequence


PR:O43526-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)
hKCNQ2/iso:2
Yes
organism-sequence


PR:O43526-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)
hKCNQ2/iso:3

organism-sequence


PR:000000916 voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)
hKCNQ2/iso:3/var:K526N
Yes
organism-sequence


PR:O43526-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)
hKCNQ2/iso:4
Yes
organism-sequence


PR:O43526-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)
hKCNQ2/iso:5

organism-sequence


PR:O43526-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)
hKCNQ2/iso:6
Yes
organism-modification


PR:000076442 potassium voltage-gated channel subfamily KQT member 2 acetylated 1 (human)
hKCNQ2/Ac:1

organism-modification


PR:000079703 potassium voltage-gated channel subfamily KQT member 2 phosphorylated 1 (human)
hKCNQ2/Phos:1

organism-gene


PR:O88943 potassium voltage-gated channel subfamily KQT member 2 (rat)
rKCNQ2

organism-sequence


PR:O88943-1 potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)
rKCNQ2/iso:A
Yes
organism-sequence


PR:O88943-2 potassium voltage-gated channel subfamily KQT member 2 isoform B (rat)
rKCNQ2/iso:B

organism-sequence


PR:O88943-3 potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)
rKCNQ2/iso:C

organism-sequence


PR:O88943-4 potassium voltage-gated channel subfamily KQT member 2 isoform D (rat)
rKCNQ2/iso:D

organism-sequence


PR:O88943-5 potassium voltage-gated channel subfamily KQT member 2 isoform E (rat)
rKCNQ2/iso:E

organism-sequence


PR:O88943-6 potassium voltage-gated channel subfamily KQT member 2 isoform F (rat)
rKCNQ2/iso:F

organism-sequence


PR:O88943-7 potassium voltage-gated channel subfamily KQT member 2 isoform G (rat)
rKCNQ2/iso:G

organism-sequence


PR:O88943-8 potassium voltage-gated channel subfamily KQT member 2 isoform H (rat)
rKCNQ2/iso:H

organism-sequence


PR:O88943-9 potassium voltage-gated channel subfamily KQT member 2 isoform I (rat)
rKCNQ2/iso:I

organism-gene


PR:Q9Z351 potassium voltage-gated channel subfamily KQT member 2 (mouse)
mKCNQ2

organism-sequence


PR:Q9Z351-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)
mKCNQ2/iso:1

organism-sequence


PR:Q9Z351-10 potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)
mKCNQ2/iso:10
Yes
organism-sequence


PR:Q9Z351-11 potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)
mKCNQ2/iso:11
Yes
organism-sequence


PR:Q9Z351-12 potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)
mKCNQ2/iso:12
Yes
organism-sequence


PR:Q9Z351-13 potassium voltage-gated channel subfamily KQT member 2 isoform m13 (mouse)
mKCNQ2/iso:m13

organism-sequence


PR:Q9Z351-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)
mKCNQ2/iso:2

organism-sequence


PR:Q9Z351-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)
mKCNQ2/iso:3

organism-sequence


PR:Q9Z351-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)
mKCNQ2/iso:4

organism-sequence


PR:Q9Z351-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)
mKCNQ2/iso:5

organism-sequence


PR:Q9Z351-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)
mKCNQ2/iso:6

organism-sequence


PR:Q9Z351-7 potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)
mKCNQ2/iso:7

organism-sequence


PR:Q9Z351-8 potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)
mKCNQ2/iso:8

organism-sequence


PR:Q9Z351-9 potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)
mKCNQ2/iso:9
Yes
sequence


PR:000000891 voltage-gated potassium channel subunit KCNQ2 isoform 1
KCNQ2/iso:1

organism-sequence


PR:O43526-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)
hKCNQ2/iso:1

organism-sequence


PR:Q9Z351-12 potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)
mKCNQ2/iso:12
Yes
sequence


PR:000000892 voltage-gated potassium channel subunit KCNQ2 isoform 10
KCNQ2/iso:10

organism-sequence


PR:Q9Z351-10 potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)
mKCNQ2/iso:10
Yes
sequence


PR:000000893 voltage-gated potassium channel subunit KCNQ2 isoform 11
KCNQ2/iso:11

organism-sequence


PR:Q9Z351-11 potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)
mKCNQ2/iso:11
Yes
sequence


PR:000000894 voltage-gated potassium channel subunit KCNQ2 isoform 12
KCNQ2/iso:12

organism-sequence


PR:Q9Z351-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)
mKCNQ2/iso:2

sequence


PR:000000895 voltage-gated potassium channel subunit KCNQ2 isoform 13
KCNQ2/iso:13

organism-sequence


PR:Q9Z351-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)
mKCNQ2/iso:3

sequence


PR:000000896 voltage-gated potassium channel subunit KCNQ2 isoform 14
KCNQ2/iso:14

organism-sequence


PR:Q9Z351-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)
mKCNQ2/iso:4

sequence


PR:000000897 voltage-gated potassium channel subunit KCNQ2 isoform 15
KCNQ2/iso:15

organism-sequence


PR:Q9Z351-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)
mKCNQ2/iso:5

sequence


PR:000000898 voltage-gated potassium channel subunit KCNQ2 isoform 16
KCNQ2/iso:16

organism-sequence


PR:Q9Z351-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)
mKCNQ2/iso:6

sequence


PR:000000899 voltage-gated potassium channel subunit KCNQ2 isoform 2
KCNQ2/iso:2

organism-sequence


PR:O43526-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)
hKCNQ2/iso:2
Yes
organism-sequence


PR:O88943-1 potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)
rKCNQ2/iso:A
Yes
organism-sequence


PR:Q9Z351-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)
mKCNQ2/iso:1

modification


PR:000002632 voltage-gated potassium channel subunit KCNQ2 isoform 2 unmodified form
KCNQ2/iso:2/UnMod

sequence


PR:000000900 voltage-gated potassium channel subunit KCNQ2 isoform 3
KCNQ2/iso:3

organism-sequence


PR:O43526-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)
hKCNQ2/iso:3

organism-sequence


PR:000000916 voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)
hKCNQ2/iso:3/var:K526N
Yes
organism-sequence


PR:O88943-3 potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)
rKCNQ2/iso:C

sequence


PR:000000901 voltage-gated potassium channel subunit KCNQ2 isoform 4
KCNQ2/iso:4

organism-sequence


PR:O43526-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)
hKCNQ2/iso:4
Yes
sequence


PR:000000902 voltage-gated potassium channel subunit KCNQ2 isoform 5
KCNQ2/iso:5

organism-sequence


PR:O43526-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)
hKCNQ2/iso:5

sequence


PR:000000903 voltage-gated potassium channel subunit KCNQ2 isoform 6
KCNQ2/iso:6

organism-sequence


PR:O43526-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)
hKCNQ2/iso:6
Yes
sequence


PR:000000904 voltage-gated potassium channel subunit KCNQ2 isoform 7
KCNQ2/iso:7

organism-sequence


PR:Q9Z351-7 potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)
mKCNQ2/iso:7

sequence


PR:000000905 voltage-gated potassium channel subunit KCNQ2 isoform 8
KCNQ2/iso:8

organism-sequence


PR:Q9Z351-8 potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)
mKCNQ2/iso:8

sequence


PR:000000906 voltage-gated potassium channel subunit KCNQ2 isoform 9
KCNQ2/iso:9

organism-sequence


PR:Q9Z351-9 potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)
mKCNQ2/iso:9
Yes
gene


PR:000000730 voltage-gated potassium channel subunit KCNQ3
KCNQ3

organism-gene


PR:O43525 potassium voltage-gated channel subfamily KQT member 3 (human)
hKCNQ3
Yes
organism-sequence


PR:O43525-1 potassium voltage-gated channel subfamily KQT member 3 isoform 1 (human)
hKCNQ3/iso:1

organism-sequence


PR:O43525-2 potassium voltage-gated channel subfamily KQT member 3 isoform h2 (human)
hKCNQ3/iso:h2

organism-gene


PR:O88944 potassium voltage-gated channel subfamily KQT member 3 (rat)
rKCNQ3

organism-sequence


PR:O88944-1 potassium voltage-gated channel subfamily KQT member 3 isoform r1 (rat)
rKCNQ3/iso:r1

organism-sequence


PR:O88944-2 potassium voltage-gated channel subfamily KQT member 3 isoform r2 (rat)
rKCNQ3/iso:r2

organism-gene


PR:Q8K3F6 potassium voltage-gated channel subfamily KQT member 3 (mouse)
mKCNQ3

organism-sequence


PR:Q8K3F6-1 potassium voltage-gated channel subfamily KQT member 3 isoform 1 (mouse)
mKCNQ3/iso:1

sequence


PR:000000917 voltage-gated potassium channel subunit KCNQ3 isoform 1
KCNQ3/iso:1

organism-sequence


PR:O43525-1 potassium voltage-gated channel subfamily KQT member 3 isoform 1 (human)
hKCNQ3/iso:1

organism-sequence


PR:Q8K3F6-1 potassium voltage-gated channel subfamily KQT member 3 isoform 1 (mouse)
mKCNQ3/iso:1

gene


PR:000000731 voltage-gated potassium channel subunit KCNQ4
KCNQ4

organism-gene


PR:P56696 potassium voltage-gated channel subfamily KQT member 4 (human)
hKCNQ4

organism-sequence


PR:000000920 voltage-gated potassium channel subunit KCNQ4 sequence variant G285C (human)
hKCNQ4/var:G285C
Yes
organism-sequence


PR:000000921 voltage-gated potassium channel subunit KCNQ4 sequence variant L274H (human)
hKCNQ4/var:L274H
Yes
organism-sequence


PR:000000922 voltage-gated potassium channel subunit KCNQ4 sequence variant G285S (human)
hKCNQ4/var:G285S
Yes
organism-sequence


PR:000000923 voltage-gated potassium channel subunit KCNQ4 sequence variant L281S (human)
hKCNQ4/var:L281S
Yes
organism-sequence


PR:000000924 voltage-gated potassium channel subunit KCNQ4 sequence variant W276S (human)
hKCNQ4/var:W276S
Yes
organism-sequence


PR:000000925 voltage-gated potassium channel subunit KCNQ4 sequence variant G321S (human)
hKCNQ4/var:G321S
Yes
organism-sequence


PR:P56696-1 potassium voltage-gated channel subfamily KQT member 4 isoform 1 (human)
hKCNQ4/iso:1

organism-sequence


PR:P56696-2 potassium voltage-gated channel subfamily KQT member 4 isoform 2 (human)
hKCNQ4/iso:2

organism-gene


PR:Q9JK97 potassium voltage-gated channel subfamily KQT member 4 (mouse)
mKCNQ4
Yes
sequence


PR:000000918 voltage-gated potassium channel subunit KCNQ4 isoform 1
KCNQ4/iso:1

organism-sequence


PR:P56696-1 potassium voltage-gated channel subfamily KQT member 4 isoform 1 (human)
hKCNQ4/iso:1

sequence


PR:000000919 voltage-gated potassium channel subunit KCNQ4 isoform 2
KCNQ4/iso:2

organism-sequence


PR:P56696-2 potassium voltage-gated channel subfamily KQT member 4 isoform 2 (human)
hKCNQ4/iso:2

gene


PR:000000732 voltage-gated potassium channel subunit KCNQ5
KCNQ5

organism-gene


PR:Q9JK45 potassium voltage-gated channel subfamily KQT member 5 (mouse)
mKCNQ5

organism-sequence


PR:Q9JK45-1 potassium voltage-gated channel subfamily KQT member 5 isoform 1 (mouse)
mKCNQ5/iso:1
Yes
organism-gene


PR:Q9NR82 potassium voltage-gated channel subfamily KQT member 5 (human)
hKCNQ5

organism-sequence


PR:Q9NR82-1 potassium voltage-gated channel subfamily KQT member 5 isoform 1 (human)
hKCNQ5/iso:1
Yes
organism-sequence


PR:Q9NR82-2 potassium voltage-gated channel subfamily KQT member 5 isoform 2 (human)
hKCNQ5/iso:2
Yes
organism-sequence


PR:Q9NR82-3 potassium voltage-gated channel subfamily KQT member 5 isoform 3 (human)
hKCNQ5/iso:3
Yes
organism-sequence


PR:Q9NR82-4 potassium voltage-gated channel subfamily KQT member 5 isoform 4 (human)
hKCNQ5/iso:4

organism-sequence


PR:Q9NR82-5 potassium voltage-gated channel subfamily KQT member 5 isoform h5 (human)
hKCNQ5/iso:h5

organism-sequence


PR:Q9NR82-6 potassium voltage-gated channel subfamily KQT member 5 isoform h6 (human)
hKCNQ5/iso:h6

organism-sequence


PR:Q9NR82-7 potassium voltage-gated channel subfamily KQT member 5 isoform h7 (human)
hKCNQ5/iso:h7

sequence


PR:000000926 voltage-gated potassium channel subunit KCNQ5 isoform 1
KCNQ5/iso:1

organism-sequence


PR:Q9JK45-1 potassium voltage-gated channel subfamily KQT member 5 isoform 1 (mouse)
mKCNQ5/iso:1
Yes
organism-sequence


PR:Q9NR82-1 potassium voltage-gated channel subfamily KQT member 5 isoform 1 (human)
hKCNQ5/iso:1
Yes
sequence


PR:000000927 voltage-gated potassium channel subunit KCNQ5 isoform 2
KCNQ5/iso:2

organism-sequence


PR:Q9NR82-2 potassium voltage-gated channel subfamily KQT member 5 isoform 2 (human)
hKCNQ5/iso:2
Yes
sequence


PR:000000928 voltage-gated potassium channel subunit KCNQ5 isoform 3
KCNQ5/iso:3

organism-sequence


PR:Q9NR82-3 potassium voltage-gated channel subfamily KQT member 5 isoform 3 (human)
hKCNQ5/iso:3
Yes
sequence


PR:000000929 voltage-gated potassium channel subunit KCNQ5 isoform 4
KCNQ5/iso:4

organism-sequence


PR:Q9NR82-4 potassium voltage-gated channel subfamily KQT member 5 isoform 4 (human)
hKCNQ5/iso:4

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006813 potassium ion transportPR:O43525 hKCNQ3 PMID:9677360
PR:Q9JK45-1 mKCNQ5/iso:1 PMID:15963599
GO:0007268 chemical synaptic transmissionPR:O43525 hKCNQ3 PMID:9425900
PR:Q9NR82-1 hKCNQ5/iso:1 PMID:10787416
GO:0007605 sensory perception of soundPR:Q9JK97 mKCNQ4 PMID:16437162
GO:0042472 inner ear morphogenesisPR:Q9JK97 mKCNQ4 PMID:16437162

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050564 autosomal dominant nonsyndromic deafnessPR:000000920 hKCNQ4/var:G285C PMID:10369879
PR:000000921 hKCNQ4/var:L274H PMID:10925378
PR:000000922 hKCNQ4/var:G285S PMID:10025409
PR:000000923 hKCNQ4/var:L281S PMID:10571947
PR:000000924 hKCNQ4/var:W276S PMID:10369879
PR:000000925 hKCNQ4/var:G321S PMID:10369879
DO:0050650 familial atrial fibrillationPR:000000851 hKCNQ1/var:S140G PMID:12522251
DO:0050793 short QT syndromePR:000000870 hKCNQ1/var:V307L PMID:15159330
DO:14264 benign neonatal seizuresPR:000000907 hKCNQ2/var:S247W PMID:12742592
PR:000000908 hKCNQ2/var:H228Q PMID:14534157
PR:000000909 hKCNQ2/var:R207W PMID:11572947
PR:000000910 hKCNQ2/var:L243F PMID:14534157
PR:000000911 hKCNQ2/var:4 PMID:11175290
PR:000000912 hKCNQ2/var:Y284C PMID:10788442
PR:000000913 hKCNQ2/var:A306T PMID:10788442
PR:000000914 hKCNQ2/var:R333Q PMID:14534157
PR:000000915 hKCNQ2/var:M208V PMID:14534157
PR:000000916 hKCNQ2/iso:3/var:K526N PMID:15249611
DO:2842 Jervell-Lange Nielsen syndromePR:000000836 hKCNQ1/var:E261D PMID:10704188
PR:000000872 hKCNQ1/var:R243H PMID:10728423
PR:000000876 hKCNQ1/var:W305S PMID:9781056
DO:2843 long QT syndromePR:000000817 hKCNQ1/var:T587M PMID:10024302; PMID:10704188
PR:000000818 hKCNQ1/var:S373P PMID:10220144; PMID:10704188
PR:000000819 hKCNQ1/var:R243C PMID:10409658; PMID:10704188
PR:000000820 hKCNQ1/var:D317N PMID:10704188; PMID:9302275; PMID:9482580
PR:000000821 hKCNQ1/var:V310I PMID:10704188
PR:000000822 hKCNQ1/var:S566F PMID:10704188
PR:000000823 hKCNQ1/var:Y315C PMID:10704188; PMID:9693036; PMID:9927399
PR:000000824 hKCNQ1/var:S225L PMID:10704188; PMID:9927399
PR:000000825 hKCNQ1/var:A178P PMID:10704188; PMID:9323054
PR:000000826 hKCNQ1/var:A178T PMID:10704188; PMID:9024139
PR:000000827 hKCNQ1/var:G189R PMID:10220144; PMID:10704188
PR:000000828 hKCNQ1/var:P448R PMID:10704188
PR:000000829 hKCNQ1/var:T309R PMID:10704188
PR:000000830 hKCNQ1/var:R591H PMID:10024302; PMID:10704188
PR:000000831 hKCNQ1/var:R366W PMID:10704188; PMID:9693036
PR:000000832 hKCNQ1/var:I313M PMID:10704188; PMID:9024139
PR:000000833 hKCNQ1/var:Y111C PMID:10704188
PR:000000834 hKCNQ1/var:R533W PMID:10704188; PMID:10728423
PR:000000835 hKCNQ1/var:G168R PMID:9693036
PR:000000837 hKCNQ1/var:A371T PMID:10704188
PR:000000838 hKCNQ1/var:29 PMID:10511610
PR:000000839 hKCNQ1/var:A341V PMID:10704188; PMID:8818942; PMID:8872472; PMID:9570196
PR:000000840 hKCNQ1/var:L250H PMID:10704188
PR:000000841 hKCNQ1/var:S349W PMID:10704188
PR:000000842 hKCNQ1/var:T391I PMID:10704188
PR:000000843 hKCNQ1/var:K318N PMID:10704188; PMID:9693036
PR:000000844 hKCNQ1/var:A344V PMID:10704188
PR:000000845 hKCNQ1/var:A525T PMID:10482963; PMID:10704188
PR:000000846 hKCNQ1/var:A341E PMID:10704188
PR:000000847 hKCNQ1/var:R583C PMID:10704188
PR:000000848 hKCNQ1/var:D242N PMID:10704188
PR:000000849 hKCNQ1/var:L342F PMID:10704188
PR:000000850 hKCNQ1/var:G306R PMID:10704188
PR:000000852 hKCNQ1/var:G269S PMID:10704188
PR:000000853 hKCNQ1/var:R555C PMID:10704188
PR:000000854 hKCNQ1/var:R539W PMID:10728423
PR:000000855 hKCNQ1/var:Y315S PMID:10220144; PMID:10704188
PR:000000856 hKCNQ1/var:R174H PMID:10367071
PR:000000857 hKCNQ1/var:A194P PMID:10704188
PR:000000858 hKCNQ1/var:Y184S PMID:10220144
PR:000000859 hKCNQ1/var:G345E PMID:10704188
PR:000000860 hKCNQ1/var:R190Q PMID:10704188; PMID:10728423
PR:000000861 hKCNQ1/var:T311I PMID:10704188; PMID:9482580
PR:000000862 hKCNQ1/var:G314S PMID:8872472; PMID:9693036
PR:000000863 hKCNQ1/var:W248R PMID:10409658
PR:000000864 hKCNQ1/var:R366P PMID:10704188; PMID:9024139
PR:000000865 hKCNQ1/var:R366Q PMID:10704188
PR:000000866 hKCNQ1/var:E160K PMID:10704188
PR:000000867 hKCNQ1/var:V254M PMID:10704188
PR:000000868 hKCNQ1/var:G345R PMID:10220144
PR:000000869 hKCNQ1/var:E261K PMID:10409658
PR:000000871 hKCNQ1/var:F339del PMID:15159330
PR:000000873 hKCNQ1/var:G179S PMID:10728423
PR:000000874 hKCNQ1/var:A300T PMID:9641694
PR:000000875 hKCNQ1/var:R174C PMID:10704188
PR:000000877 hKCNQ1/var:L266P PMID:10704188
PR:000000878 hKCNQ1/var:R594Q PMID:10704188
PR:000000879 hKCNQ1/var:L273F PMID:9323054
PR:000000880 hKCNQ1/var:Y281C PMID:9927399
PR:000000881 hKCNQ1/var:P320A PMID:10704188
PR:000000882 hKCNQ1/var:F157C PMID:10220146
PR:000000883 hKCNQ1/var:L353P PMID:9693036
PR:000000884 hKCNQ1/var:G325R PMID:9024139
PR:000000885 hKCNQ1/var:W392R PMID:10220144
PR:000000886 hKCNQ1/var:G269D PMID:10704188
PR:000000887 hKCNQ1/var:G589D PMID:10704188
PR:000000888 hKCNQ1/var:G216R PMID:9272155
PR:000000889 hKCNQ1/var:V417M PMID:10704188
PR:000000890 hKCNQ1/var:T312I PMID:10409658; PMID:9323054
MP:0003233 prolonged QT intervalPR:000000846 hKCNQ1/var:A341E PMID:15498462

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005249 voltage-gated potassium channel activityPR:000000907 hKCNQ2/var:S247W PMID:12742592
PR:000000909 hKCNQ2/var:R207W PMID:11572947
PR:000000920 hKCNQ4/var:G285C PMID:10369879
PR:000000922 hKCNQ4/var:G285S PMID:10025409
PR:Q9JK45-1 mKCNQ5/iso:1 PMID:15963599
PR:Q9NR82-2 hKCNQ5/iso:2 PMID:10816588
PR:Q9NR82-3 hKCNQ5/iso:3 PMID:10816588
contributes_to GO:0005249 voltage-gated potassium channel activityPR:000000684 fam:Kchan_sub-KQT PIRSF:PIRSF038513
PR:O43526-2 hKCNQ2/iso:2 PMID:11160379
PR:O88943-1 rKCNQ2/iso:A PMID:11038262
decreased|contributes_to GO:0005249 voltage-gated potassium channel activityPR:O43526-6 hKCNQ2/iso:6 PMID:9039501
GO:0005251 delayed rectifier potassium channel activityPR:000000819 hKCNQ1/var:R243C PMID:10409658
PR:000000834 hKCNQ1/var:R533W PMID:10704188; PMID:10728423
PR:000000854 hKCNQ1/var:R539W PMID:10728423
altered|contributes_to GO:0005251 delayed rectifier potassium channel activityPR:000000863 hKCNQ1/var:W248R PMID:10409658
contributes_to GO:0005251 delayed rectifier potassium channel activityPR:000000874 hKCNQ1/var:A300T PMID:9641694
PR:000000879 hKCNQ1/var:L273F PMID:9323054
PR:O43526-4 hKCNQ2/iso:4 PMID:9836639
PR:P51787-1 hKCNQ1/iso:1 PMID:9312006
decreased|contributes_to GO:0005251 delayed rectifier potassium channel activityPR:000000872 hKCNQ1/var:R243H PMID:10728423
NOT|contributes_to GO:0005251 delayed rectifier potassium channel activityPR:000000825 hKCNQ1/var:A178P PMID:10704188; PMID:9323054
PR:000000860 hKCNQ1/var:R190Q PMID:10728423
PR:000000869 hKCNQ1/var:E261K PMID:8900283
PR:000000890 hKCNQ1/var:T312I PMID:10409658; PMID:9323054
GO:0005267 potassium channel activityPR:000000851 hKCNQ1/var:S140G PMID:12522251
PR:000000870 hKCNQ1/var:V307L PMID:15159330
GO:0005516 calmodulin bindingPR:Q9Z351-12 mKCNQ2/iso:12 PMID:12223552
NOT GO:0022832 voltage-gated channel activityPR:Q9Z351-10 mKCNQ2/iso:10 PMID:9666519
PR:Q9Z351-11 mKCNQ2/iso:11 PMID:9666519
PR:Q9Z351-9 mKCNQ2/iso:9 PMID:9666519
contributes_to GO:0043267 negative regulation of potassium ion transportPR:P51787-2 hKCNQ1/iso:2 PMID:9305853

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0008076 voltage-gated potassium channel complexPR:000000684 fam:Kchan_sub-KQT PIRSF:PIRSF038513
PR:000000863 hKCNQ1/var:W248R PMID:10728423
PR:000000872 hKCNQ1/var:R243H PMID:10728423
PR:Q9NR82-1 hKCNQ5/iso:1 PMID:10787416
PR:Q9Z351-12 mKCNQ2/iso:12 PMID:12223552
altered GO:0008076 voltage-gated potassium channel complexPR:000000854 hKCNQ1/var:R539W PMID:10728423
NOT GO:0008076 voltage-gated potassium channel complexPR:000000860 hKCNQ1/var:R190Q PMID:10728423
PR:000000869 hKCNQ1/var:E261K PMID:8900283
GO:0009986 cell surfacePR:000000912 hKCNQ2/var:Y284C PMID:10788442
PR:000000913 hKCNQ2/var:A306T PMID:10788442
PR:Q9Z351-12 mKCNQ2/iso:12 PMID:12223552
SO:0001557 polypeptide_gain_of_function_variantPR:000000851 hKCNQ1/var:S140G PMID:12522251
PR:000000870 hKCNQ1/var:V307L PMID:15159330
SO:0001559 polypeptide_loss_of_function_variantPR:000000825 hKCNQ1/var:A178P PMID:9323054
PR:000000860 hKCNQ1/var:R190Q PMID:10704188; PMID:9482580
PR:000000890 hKCNQ1/var:T312I PMID:10409658; PMID:9323054
SO:0001561 polypeptide_partial_loss_of_functionPR:000000863 hKCNQ1/var:W248R PMID:10409658
PR:000000879 hKCNQ1/var:L273F PMID:9323054