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Protein Ontology report - voltage-gated potassium channel alpha subunit with PAS domain
PR:000000682 - http://purl.obolibrary.org/obo/PR_000000682
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000682   
  PRO namevoltage-gated potassium channel alpha subunit with PAS domain 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_sub-a_PAS
  Definition"A voltage-gated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. Unique to this class is the presence of an N-terminal PAS fold domain (Pfam:PF00989). In addition, in the cytoplasmic region downstream from S6, there is a segment that shares substantial similarity to the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) present in cyclic nucleotide-gated cation channel subunits (PR:000000674 and PR:000000674). These channels regulate membrane excitability." [PMID:8159766] 
  PRO Categoryfamily 
  ParentPR:000044654 voltage-gated potassium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family4                                                  Organism-Family 0                                        
         Gene8                                                  Organism-Gene 23                                        
         Sequence15                                                  Organism-Sequence 27                                        
         Modification7                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038287
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000682 voltage-gated potassium channel alpha subunit with PAS domain
fam:Kchan_sub-a_PAS
Yes
family


PR:000000719 voltage-gated potassium channel Eag alpha subunit
fam:Kchan_Eag_a

gene


PR:000000790 voltage-gated delayed rectifier potassium channel KCNH1
KCNH1

organism-gene


PR:O95259 voltage-gated delayed rectifier potassium channel KCNH1 (human)
hKCNH1

organism-sequence


PR:O95259-1 voltage-gated delayed rectifier potassium channel KCNH1 isoform 2 (human)
hKCNH1/iso:2

organism-sequence


PR:O95259-2 voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 (human)
hKCNH1/iso:1
Yes
organism-gene


PR:Q02280 potassium voltage-gated channel protein eag (fruit fly)
fly-KCNH1

organism-gene


PR:Q60603 voltage-gated delayed rectifier potassium channel KCNH1 (mouse)
mKCNH1

organism-gene


PR:Q63472 voltage-gated delayed rectifier potassium channel KCNH1 (rat)
rKCNH1

sequence


PR:000000955 voltage-gated delayed rectifier potassium channel KCNH1 isoform 1
KCNH1/iso:1

organism-sequence


PR:O95259-2 voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 (human)
hKCNH1/iso:1
Yes
modification


PR:000002664 voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 unmodified form
KCNH1/iso:1/UnMod

sequence


PR:000000956 voltage-gated delayed rectifier potassium channel KCNH1 isoform 2
KCNH1/iso:2

organism-sequence


PR:O95259-1 voltage-gated delayed rectifier potassium channel KCNH1 isoform 2 (human)
hKCNH1/iso:2

gene


PR:000000794 voltage-gated delayed rectifier potassium channel KCNH5
KCNH5

organism-gene


PR:Q8NCM2 voltage-gated delayed rectifier potassium channel KCNH5 (human)
hKCNH5
Yes
organism-sequence


PR:Q8NCM2-1 voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 (human)
hKCNH5/iso:1

organism-sequence


PR:Q8NCM2-2 voltage-gated delayed rectifier potassium channel KCNH5 isoform 2 (human)
hKCNH5/iso:2

organism-sequence


PR:Q8NCM2-3 voltage-gated delayed rectifier potassium channel KCNH5 isoform 3 (human)
hKCNH5/iso:3

organism-gene


PR:Q920E3 voltage-gated delayed rectifier potassium channel KCNH5 (mouse)
mKCNH5

organism-sequence


PR:Q920E3-1 potassium voltage-gated channel subfamily H member 5 isoform 1 (mouse)
mKCNH5/iso:1

organism-gene


PR:Q9EPI9 voltage-gated delayed rectifier potassium channel KCNH5 (rat)
rKCNH5

sequence


PR:000000963 voltage-gated delayed rectifier potassium channel KCNH5 isoform 1
KCNH5/iso:1

organism-sequence


PR:Q8NCM2-1 voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 (human)
hKCNH5/iso:1

organism-sequence


PR:Q920E3-1 potassium voltage-gated channel subfamily H member 5 isoform 1 (mouse)
mKCNH5/iso:1

sequence


PR:000000964 voltage-gated delayed rectifier potassium channel KCNH5 isoform 2
KCNH5/iso:2

organism-sequence


PR:Q8NCM2-2 voltage-gated delayed rectifier potassium channel KCNH5 isoform 2 (human)
hKCNH5/iso:2

sequence


PR:000000965 voltage-gated delayed rectifier potassium channel KCNH5 isoform 3
KCNH5/iso:3

organism-sequence


PR:Q8NCM2-3 voltage-gated delayed rectifier potassium channel KCNH5 isoform 3 (human)
hKCNH5/iso:3

family


PR:000000720 voltage-gated potassium channel Elk alpha subunit
fam:Kchan_Elk_a

gene


PR:000000792 voltage-gated inwardly rectifying potassium channel KCNH3
KCNH3

organism-gene


PR:O89047 voltage-gated inwardly rectifying potassium channel KCNH3 (rat)
rKCNH3

organism-gene


PR:Q9ULD8 voltage-gated inwardly rectifying potassium channel KCNH3 (human)
hKCNH3

organism-sequence


PR:Q9ULD8-1 voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1 (human)
hKCNH3/iso:1

organism-gene


PR:Q9WVJ0 voltage-gated inwardly rectifying potassium channel KCNH3 (mouse)
mKCNH3

sequence


PR:000000961 voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1
KCNH3/iso:1

organism-sequence


PR:Q9ULD8-1 voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1 (human)
hKCNH3/iso:1

gene


PR:000000793 voltage-gated potassium channel KCNH4
KCNH4

organism-gene


PR:Q9R1T9 voltage-gated delayed rectifier potassium channel KCNH4 (rat)
rKCNH4

organism-gene


PR:Q9UQ05 voltage-gated delayed rectifier potassium channel KCNH4 (human)
hKCNH4

organism-sequence


PR:Q9UQ05-1 voltage-gated delayed rectifier potassium channel KCNH4 isoform 1 (human)
hKCNH4/iso:1
Yes
sequence


PR:000000962 voltage-gated potassium channel KCNH4 isoform 1
KCNH4/iso:1

organism-sequence


PR:Q9UQ05-1 voltage-gated delayed rectifier potassium channel KCNH4 isoform 1 (human)
hKCNH4/iso:1
Yes
gene


PR:000000797 voltage-gated delayed rectifier potassium channel KCNH8
KCNH8

organism-gene


PR:P59111 voltage-gated delayed rectifier potassium channel KCNH8 (mouse)
mKCNH8

organism-gene


PR:Q96L42 voltage-gated delayed rectifier potassium channel KCNH8 (human)
hKCNH8
Yes
organism-sequence


PR:Q96L42-1 voltage-gated delayed rectifier potassium channel KCNH8 isoform h1 (human)
hKCNH8/iso:h1

organism-sequence


PR:Q96L42-2 voltage-gated delayed rectifier potassium channel KCNH8 isoform h2 (human)
hKCNH8/iso:h2

organism-modification


PR:000065070 voltage-gated delayed rectifier potassium channel KCNH8 deaminated 1 (human)
hKCNH8/Deam:1

organism-gene


PR:Q9QWS8 voltage-gated delayed rectifier potassium channel KCNH8 (rat)
rKCNH8

family


PR:000000721 voltage-gated potassium channel Erg alpha subunit
fam:Kchan_Erg_a

gene


PR:000000791 voltage-gated inwardly rectifying potassium channel KCNH2
KCNH2

organism-gene


PR:O08962 voltage-gated inwardly rectifying potassium channel KCNH2 (rat)
rKCNH2

organism-gene


PR:O35219 voltage-gated inwardly rectifying potassium channel KCNH2 (mouse)
mKCNH2

organism-sequence


PR:O35219-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)
mKCNH2/iso:A
Yes
organism-modification


PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)
mKCNH2/iso:A/NGlyco:1
Yes
organism-sequence


PR:O35219-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)
mKCNH2/iso:1A'
Yes
organism-sequence


PR:O35219-3 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)
mKCNH2/iso:B
Yes
organism-gene


PR:Q12809 voltage-gated inwardly rectifying potassium channel KCNH2 (human)
hKCNH2
Yes
organism-sequence


PR:Q12809-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)
hKCNH2/iso:A
Yes
organism-modification


PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)
hKCNH2/iso:A/NGlyco:1
Yes
organism-modification


PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)
hKCNH2/iso:A/Phos:1
Yes
organism-modification


PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)
hKCNH2/iso:A/UnGlyco:1
Yes
organism-modification


PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)
hKCNH2/iso:A/PhosRes-
Yes
organism-sequence


PR:Q12809-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)
hKCNH2/iso:B
Yes
organism-sequence


PR:Q12809-4 voltage-gated inwardly rectifying potassium channel KCNH2 isoform h4 (human)
hKCNH2/iso:h4

organism-sequence


PR:Q12809-5 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)
hKCNH2/iso:A-USO
Yes
organism-sequence


PR:Q12809-6 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B-USO (human)
hKCNH2/iso:B-USO

organism-sequence


PR:Q12809-7 voltage-gated inwardly rectifying potassium channel KCNH2 isoform h3.1 (human)
hKCNH2/iso:h3.1

sequence


PR:000000957 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A
KCNH2/iso:A

organism-sequence


PR:O35219-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)
mKCNH2/iso:A
Yes
organism-modification


PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)
mKCNH2/iso:A/NGlyco:1
Yes
organism-sequence


PR:Q12809-1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)
hKCNH2/iso:A
Yes
organism-modification


PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)
hKCNH2/iso:A/NGlyco:1
Yes
organism-modification


PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)
hKCNH2/iso:A/Phos:1
Yes
organism-modification


PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)
hKCNH2/iso:A/UnGlyco:1
Yes
organism-modification


PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)
hKCNH2/iso:A/PhosRes-
Yes
modification


PR:000000989 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form
KCNH2/iso:A/GlycoRes+

modification


PR:000000998 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1
KCNH2/iso:A/NGlyco:1

organism-modification


PR:000036581 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)
hKCNH2/iso:A/NGlyco:1
Yes
organism-modification


PR:000036582 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)
mKCNH2/iso:A/NGlyco:1
Yes
modification


PR:000000990 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form
KCNH2/iso:A/PhosRes+

modification


PR:000000999 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1
KCNH2/iso:A/Phos:1

organism-modification


PR:000036583 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)
hKCNH2/iso:A/Phos:1
Yes
modification


PR:000002666 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unmodified form
KCNH2/iso:A/UnMod

organism-modification


PR:000045393 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)
hKCNH2/iso:A/PhosRes-
Yes
modification


PR:000045391 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1
KCNH2/iso:A/UnGlyco:1

organism-modification


PR:000045392 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)
hKCNH2/iso:A/UnGlyco:1
Yes
sequence


PR:000000958 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B
KCNH2/iso:B

organism-sequence


PR:O35219-3 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)
mKCNH2/iso:B
Yes
organism-sequence


PR:Q12809-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)
hKCNH2/iso:B
Yes
sequence


PR:000000959 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO
KCNH2/iso:A-USO

organism-sequence


PR:Q12809-5 voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)
hKCNH2/iso:A-USO
Yes
sequence


PR:000000960 voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A'
KCNH2/iso:1A'

organism-sequence


PR:O35219-2 voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)
mKCNH2/iso:1A'
Yes
gene


PR:000000795 voltage-gated inwardly rectifying potassium channel KCNH6
KCNH6

organism-gene


PR:O54853 voltage-gated inwardly rectifying potassium channel KCNH6 (rat)
rKCNH6

organism-gene


PR:Q9H252 voltage-gated inwardly rectifying potassium channel KCNH6 (human)
hKCNH6

organism-sequence


PR:Q9H252-1 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1 (human)
hKCNH6/iso:1

organism-sequence


PR:Q9H252-2 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2 (human)
hKCNH6/iso:2

organism-sequence


PR:Q9H252-3 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3 (human)
hKCNH6/iso:3

organism-sequence


PR:Q9H252-4 voltage-gated inwardly rectifying potassium channel KCNH6 isoform h1 (human)
hKCNH6/iso:h1

organism-modification


PR:000067679 voltage-gated inwardly rectifying potassium channel KCNH6 phosphorylated 1 (human)
hKCNH6/Phos:1

sequence


PR:000000966 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1
KCNH6/iso:1

organism-sequence


PR:Q9H252-1 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1 (human)
hKCNH6/iso:1

sequence


PR:000000967 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2
KCNH6/iso:2

organism-sequence


PR:Q9H252-2 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2 (human)
hKCNH6/iso:2

sequence


PR:000000968 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3
KCNH6/iso:3

organism-sequence


PR:Q9H252-3 voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3 (human)
hKCNH6/iso:3

gene


PR:000000796 voltage-gated inwardly rectifying potassium channel KCNH7
KCNH7

organism-gene


PR:O54852 voltage-gated inwardly rectifying potassium channel KCNH7 (rat)
rKCNH7

organism-sequence


PR:O54852-1 voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (rat)
rKCNH7/iso:1

organism-gene


PR:Q9ER47 voltage-gated inwardly rectifying potassium channel KCNH7 (mouse)
mKCNH7

organism-sequence


PR:Q9ER47-1 voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (mouse)
mKCNH7/iso:1

organism-gene


PR:Q9NS40 voltage-gated inwardly rectifying potassium channel KCNH7 (human)
hKCNH7

organism-sequence


PR:Q9NS40-1 voltage-gated inwardly rectifying potassium channel KCNH7 isoform h1 (human)
hKCNH7/iso:h1

organism-sequence


PR:Q9NS40-2 voltage-gated inwardly rectifying potassium channel KCNH7 isoform h2 (human)
hKCNH7/iso:h2

organism-modification


PR:000068261 voltage-gated inwardly rectifying potassium channel KCNH7 deaminated 1 (human)
hKCNH7/Deam:1

sequence


PR:000043159 voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1
KCNH7/iso:1

organism-sequence


PR:O54852-1 voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (rat)
rKCNH7/iso:1

organism-sequence


PR:Q9ER47-1 voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (mouse)
mKCNH7/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000682 fam:Kchan_sub-a_PAS
These channels regulate membrane excitability		 enablescontributes_to GO:0005249 voltage-gated potassium channel activity PIRSF:PIRSF038287
located_inGO:0008076 voltage-gated potassium channel complex PIRSF:PIRSF038287
PR:000036581 hKCNH2/iso:A/NGlyco:1
UniProtKB:Q12809-1, Asn-598, MOD:00160		 located_inGO:0008076 voltage-gated potassium channel complex PMID:12063277
GO:0009986 cell surface PMID:12063277
PR:000036582 mKCNH2/iso:A/NGlyco:1
UniProtKB:O35219-1, Asn-600, MOD:00160		 located_inGO:0005886 plasma membrane MGI_ref:3040012; PMID:14668215
PR:000036583 hKCNH2/iso:A/Phos:1 enablesdecreased GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:10837251
located_inGO:0008076 voltage-gated potassium channel complex PMID:10837251
PR:000045392 hKCNH2/iso:A/UnGlyco:1
UniProtKB:Q12809-1, Asn-598, PR:000026291		 located_inGO:0009986 cell surface PMID:12063277
PR:000045393 hKCNH2/iso:A/PhosRes- enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10837251; PMID:9351446
PR:O35219-1 mKCNH2/iso:A enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446; PMID:9351462
located_inGO:0005635 nuclear envelope MGI_ref:3040012; PMID:14668215
GO:0005635 nuclear envelope MGI_ref:3040012; PMID:14668215
GO:0005737 cytoplasm MGI_ref:3040012; PMID:14668215
GO:0005737 cytoplasm MGI_ref:3040012; PMID:14668215
GO:0005886 plasma membrane MGI_ref:3040012; PMID:14668215
GO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O35219-2 mKCNH2/iso:1A' enablesGO:0005251 delayed rectifier potassium channel activity PMID:9351462
located_inGO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O35219-3 mKCNH2/iso:B enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446; PMID:9351462
located_inGO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O95259-2 hKCNH1/iso:1 acts_upstream_of_or_withinGO:0007520 myoblast fusion PMID:9738473
enablesGO:0005251 delayed rectifier potassium channel activity PMID:9738473
GO:0005516 calmodulin binding PMID:10880439
located_inGO:0008076 voltage-gated potassium channel complex PMID:11943152; PMID:9738473
PR:Q12809 hKCNH2 acts_upstream_of_or_withinGO:0006936 muscle contraction PMID:7736582
GO:0008016 regulation of heart contraction PMID:7736582
PR:Q12809-1 hKCNH2/iso:A enablesGO:0030552 cAMP binding PMID:10837251
PR:Q12809-2 hKCNH2/iso:B enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446
PR:Q12809-5 hKCNH2/iso:A-USO enablesaltered|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:9765245
located_inGO:0008076 voltage-gated potassium channel complex PMID:9765245
PR:Q8NCM2 hKCNH5 located_inGO:0008076 voltage-gated potassium channel complex PMID:11943152; PMID:9738473
PR:Q96L42 hKCNH8 enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:12890647
PR:Q9UQ05-1 hKCNH4/iso:1 located_inGO:0008076 voltage-gated potassium channel complex PMID:10455180