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Protein Ontology report - transient receptor potential cation channel TRPC
PR:000000680 - http://purl.obolibrary.org/obo/PR_000000680
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000680   
  PRO nametransient receptor potential cation channel TRPC 
  Synonyms
PRO-Short-label: EXACT:fam:TRPC
  Definition"A transient receptor potential channel protein that is a member of the subfamily C of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 4 detectable copies of Ankyrin repeat (Pfam:PF00023) followed by the Transient receptor ion channel II domain (Pfam:PF08344). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000044657 transient receptor potential channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family3                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 17                                        
         Sequence12                                                  Organism-Sequence 31                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF005528
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000680 transient receptor potential cation channel TRPC
fam:TRPC

family


PR:000000718 transient receptor potential cation channel TRPC3/6/7
fam:TRPC[3/6/7]

gene


PR:000000775 short transient receptor potential cation channel TRPC3
TRPC3

organism-gene


PR:P34586 transient-receptor-potential-like protein (worm)
TRPC3 (worm)

organism-gene


PR:Q13507 short transient receptor potential channel 3 (human)
hTRPC3

organism-sequence


PR:Q13507-1 short transient receptor potential channel 3 isoform 1 (human)
hTRPC3/iso:1
Yes
organism-sequence


PR:Q13507-2 short transient receptor potential channel 3 isoform h1 (human)
hTRPC3/iso:h1

organism-sequence


PR:Q13507-3 short transient receptor potential channel 3 isoform h2 (human)
hTRPC3/iso:h2

organism-gene


PR:Q9JMI9 short transient receptor potential channel 3 (rat)
rTRPC3

organism-gene


PR:Q9QZC1 short transient receptor potential channel 3 (mouse)
mTRPC3

sequence


PR:000000937 short transient receptor potential cation channel TRPC3 isoform 1
TRPC3/iso:1

organism-sequence


PR:Q13507-1 short transient receptor potential channel 3 isoform 1 (human)
hTRPC3/iso:1
Yes
gene


PR:000001080 short transient receptor potential cation channel TRPC7
TRPC7

organism-gene


PR:Q9HCX4 short transient receptor potential channel 7 (human)
hTRPC7
Yes
organism-sequence


PR:Q9HCX4-1 short transient receptor potential channel 7 isoform 1 (human)
hTRPC7/iso:1

organism-sequence


PR:Q9HCX4-2 short transient receptor potential channel 7 isoform h2 (human)
hTRPC7/iso:h2

organism-sequence


PR:Q9HCX4-3 short transient receptor potential channel 7 isoform h3 (human)
hTRPC7/iso:h3

organism-gene


PR:Q9WVC5 short transient receptor potential channel 7 (mouse)
mTRPC7

organism-sequence


PR:Q9WVC5-1 short transient receptor potential channel 7 isoform 1 (mouse)
mTRPC7/iso:1
Yes
sequence


PR:000001081 short transient receptor potential cation channel TRPC7 isoform 1
TRPC7/iso:1

organism-sequence


PR:Q9HCX4-1 short transient receptor potential channel 7 isoform 1 (human)
hTRPC7/iso:1

organism-sequence


PR:Q9WVC5-1 short transient receptor potential channel 7 isoform 1 (mouse)
mTRPC7/iso:1
Yes
gene


PR:000016696 short transient receptor potential channel 6
TRPC6

organism-gene


PR:Q61143 short transient receptor potential channel 6 (mouse)
mTRPC6

organism-gene


PR:Q9Y210 short transient receptor potential channel 6 (human)
hTRPC6

organism-sequence


PR:Q9Y210-1 short transient receptor potential channel 6 isoform h1 (human)
hTRPC6/iso:h1

organism-sequence


PR:Q9Y210-2 short transient receptor potential channel 6 isoform h2 (human)
hTRPC6/iso:h2

organism-sequence


PR:Q9Y210-3 short transient receptor potential channel 6 isoform h3 (human)
hTRPC6/iso:h3

organism-modification


PR:000058350 short transient receptor potential channel 6 N-glycosylated 1 (human)
hTRPC6/NGlyco:1

organism-modification


PR:000058351 short transient receptor potential channel 6 N-glycosylated 2 (human)
hTRPC6/NGlyco:2

organism-modification


PR:000072935 short transient receptor potential channel 6 phosphorylated 1 (human)
hTRPC6/Phos:1

family


PR:000001074 transient receptor potential cation channel TRPC with PDZ-binding motif
TRPV4/iso:E

gene


PR:000001075 short transient receptor potential cation channel TRPC4
TRPC4

organism-gene


PR:O35119 short transient receptor potential channel 4 (rat)
rTRPC4

organism-sequence


PR:O35119-1 short transient receptor potential channel 4 isoform alpha (rat)
rTRPC4/iso:Alpha

organism-sequence


PR:O35119-2 short transient receptor potential channel 4 isoform beta (rat)
rTRPC4/iso:Beta

organism-gene


PR:Q9QUQ5 short transient receptor potential channel 4 (mouse)
mTRPC4
Yes
organism-sequence


PR:Q9QUQ5-1 short transient receptor potential channel 4 isoform alpha (mouse)
mTRPC4/iso:Alpha
Yes
organism-sequence


PR:Q9QUQ5-2 short transient receptor potential channel 4 isoform beta (mouse)
mTRPC4/iso:Beta

organism-gene


PR:Q9UBN4 short transient receptor potential channel 4 (human)
hTRPC4

organism-sequence


PR:Q9UBN4-1 short transient receptor potential channel 4 isoform alpha (human)
hTRPC4/iso:Alpha
Yes
organism-sequence


PR:Q9UBN4-2 short transient receptor potential channel 4 isoform beta (human)
hTRPC4/iso:Beta
Yes
organism-sequence


PR:Q9UBN4-3 short transient receptor potential channel 4 isoform delta (human)
hTRPC4/iso:Delta

organism-sequence


PR:Q9UBN4-4 short transient receptor potential channel 4 isoform gamma (human)
hTRPC4/iso:Gamma

organism-sequence


PR:Q9UBN4-5 short transient receptor potential channel 4 isoform Epsilon (human)
hTRPC4/iso:Epsilon

organism-sequence


PR:Q9UBN4-6 short transient receptor potential channel 4 isoform Zeta (human)
hTRPC4/iso:Zeta

organism-sequence


PR:Q9UBN4-7 short transient receptor potential channel 4 isoform Eta (human)
hTRPC4/iso:Eta

sequence


PR:000001076 short transient receptor potential cation channel TRPC4 isoform 1
TRPC4/iso:1

organism-sequence


PR:O35119-1 short transient receptor potential channel 4 isoform alpha (rat)
rTRPC4/iso:Alpha

organism-sequence


PR:Q9QUQ5-1 short transient receptor potential channel 4 isoform alpha (mouse)
mTRPC4/iso:Alpha
Yes
organism-sequence


PR:Q9UBN4-1 short transient receptor potential channel 4 isoform alpha (human)
hTRPC4/iso:Alpha
Yes
sequence


PR:000001077 short transient receptor potential cation channel TRPC4 isoform 2
TRPC4/iso:2

organism-sequence


PR:O35119-2 short transient receptor potential channel 4 isoform beta (rat)
rTRPC4/iso:Beta

organism-sequence


PR:Q9QUQ5-2 short transient receptor potential channel 4 isoform beta (mouse)
mTRPC4/iso:Beta

organism-sequence


PR:Q9UBN4-2 short transient receptor potential channel 4 isoform beta (human)
hTRPC4/iso:Beta
Yes
sequence


PR:000001078 short transient receptor potential cation channel TRPC4 isoform 3
TRPC4/iso:3

organism-sequence


PR:Q9UBN4-3 short transient receptor potential channel 4 isoform delta (human)
hTRPC4/iso:Delta

sequence


PR:000001079 short transient receptor potential cation channel TRPC4 isoform 4
TRPC4/iso:4

organism-sequence


PR:Q9UBN4-4 short transient receptor potential channel 4 isoform gamma (human)
hTRPC4/iso:Gamma

gene


PR:000001725 short transient receptor potential cation channel TRPC2
Trpc2

organism-gene


PR:Q9R244 short transient receptor potential channel 2 (mouse)
mTrpc2
Yes
organism-sequence


PR:Q9R244-1 short transient receptor potential channel 2 isoform 1 (mouse)
mTrpc2/iso:1
Yes
organism-sequence


PR:Q9R244-2 short transient receptor potential channel 2 isoform 2 (mouse)
mTrpc2/iso:2
Yes
organism-sequence


PR:Q9R244-3 short transient receptor potential channel 2 isoform 3 (mouse)
mTrpc2/iso:3
Yes
organism-sequence


PR:Q9R244-4 short transient receptor potential channel 2 isoform 4 (mouse)
mTrpc2/iso:4
Yes
sequence


PR:000001726 short transient receptor potential cation channel TRPC2 isoform 1
Trpc2/iso:1

organism-sequence


PR:Q9R244-1 short transient receptor potential channel 2 isoform 1 (mouse)
mTrpc2/iso:1
Yes
sequence


PR:000001727 short transient receptor potential cation channel TRPC2 isoform 2
Trpc2/iso:2

organism-sequence


PR:Q9R244-2 short transient receptor potential channel 2 isoform 2 (mouse)
mTrpc2/iso:2
Yes
sequence


PR:000001728 short transient receptor potential cation channel TRPC2 isoform 3
Trpc2/iso:3

organism-sequence


PR:Q9R244-3 short transient receptor potential channel 2 isoform 3 (mouse)
mTrpc2/iso:3
Yes
sequence


PR:000001729 short transient receptor potential cation channel TRPC2 isoform 4
Trpc2/iso:4

organism-sequence


PR:Q9R244-4 short transient receptor potential channel 2 isoform 4 (mouse)
mTrpc2/iso:4
Yes
gene


PR:000016693 short transient receptor potential channel 1
TRPC1

organism-gene


PR:P48995 short transient receptor potential channel 1 (human)
hTRPC1

organism-sequence


PR:P48995-1 short transient receptor potential channel 1 isoform Long (human)
hTRPC1/iso:Long

organism-sequence


PR:P48995-2 short transient receptor potential channel 1 isoform Short (human)
hTRPC1/iso:Short

organism-gene


PR:Q61056 short transient receptor potential channel 1 (mouse)
mTRPC1

organism-sequence


PR:Q61056-1 short transient receptor potential channel 1 isoform Alpha (mouse)
mTRPC1/iso:Alpha

organism-sequence


PR:Q61056-2 short transient receptor potential channel 1 isoform Beta (mouse)
mTRPC1/iso:Beta

organism-gene


PR:Q9QX01 short transient receptor potential channel 1 (rat)
rTRPC1

organism-sequence


PR:Q9QX01-1 short transient receptor potential channel 1 isoform Beta (rat)
rTRPC1/iso:Beta

organism-sequence


PR:Q9QX01-2 short transient receptor potential channel 1 isoform Alpha (rat)
rTRPC1/iso:Alpha

sequence


PR:000039570 short transient receptor potential channel 1 isoform 1
TRPC1/iso:1

organism-sequence


PR:P48995-1 short transient receptor potential channel 1 isoform Long (human)
hTRPC1/iso:Long

organism-sequence


PR:Q61056-1 short transient receptor potential channel 1 isoform Alpha (mouse)
mTRPC1/iso:Alpha

sequence


PR:000039571 short transient receptor potential channel 1 isoform 2
TRPC1/iso:2

organism-sequence


PR:P48995-2 short transient receptor potential channel 1 isoform Short (human)
hTRPC1/iso:Short

organism-sequence


PR:Q61056-2 short transient receptor potential channel 1 isoform Beta (mouse)
mTRPC1/iso:Beta

gene


PR:000016695 short transient receptor potential channel 5
TRPC5

organism-gene


PR:Q9QX29 short transient receptor potential channel 5 (mouse)
mTRPC5

organism-gene


PR:Q9UL62 short transient receptor potential channel 5 (human)
hTRPC5

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006816 calcium ion transportPR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066
GO:0007602 phototransductionPR:Q13507-1 hTRPC3/iso:1 PMID:9215637
GO:0014051 gamma-aminobutyric acid secretionPR:Q9QUQ5 mTRPC4 PMID:14668438
NOT GO:0015279 store-operated calcium channel activityPR:Q9R244 mTrpc2 PMID:10998353

Molecular Function GO Term
Protein Forms & Complexes
Evidence
contributes_to GO:0005262 calcium channel activityPR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066
GO:0005515 protein bindingPR:Q13507-1 hTRPC3/iso:1 PMID:15744307
PR:Q9HCX4 hTRPC7 PMID:15757897
GO:0005516 calmodulin bindingPR:Q9R244-1 mTrpc2/iso:1 MGI_ref:2652910; PMID:12601176
PR:Q9R244-2 mTrpc2/iso:2 PMID:12601176
contributes_to GO:0006828 manganese ion transportPR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066
GO:0015279 store-operated calcium channel activityPR:Q13507-1 hTRPC3/iso:1 PMID:9215637
PR:Q9QUQ5-1 mTRPC4/iso:Alpha MGI_ref:3525810; PMID:15044151
contributes_to GO:0015279 store-operated calcium channel activityPR:Q9UBN4-1 hTRPC4/iso:Alpha PMID:11713258
PR:Q9UBN4-2 hTRPC4/iso:Beta PMID:11713258
GO:0042802 identical protein bindingPR:Q9UBN4-1 hTRPC4/iso:Alpha PMID:11713258
PR:Q9UBN4-2 hTRPC4/iso:Beta PMID:11713258

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0000139 Golgi membranePR:Q9R244-3 mTrpc2/iso:3 MGI_ref:1913270; PMID:10998353
PR:Q9R244-4 mTrpc2/iso:4 PMID:10998353
GO:0005635 nuclear envelopePR:Q9R244-3 mTrpc2/iso:3 MGI_ref:1913270; PMID:10998353
PR:Q9R244-4 mTrpc2/iso:4 MGI_ref:1913270; PMID:10998353
GO:0005789 endoplasmic reticulum membranePR:Q9R244-3 mTrpc2/iso:3 MGI_ref:1913270; PMID:10998353
PR:Q9R244-4 mTrpc2/iso:4 MGI_ref:1913270; PMID:10998353
GO:0005886 plasma membranePR:Q13507-1 hTRPC3/iso:1 PMID:9368034
PR:Q9QUQ5-1 mTRPC4/iso:Alpha MGI_ref:3525810; PMID:15044151
PR:Q9UBN4-1 hTRPC4/iso:Alpha PMID:11713258
PR:Q9UBN4-2 hTRPC4/iso:Beta PMID:11713258
GO:0005901 caveolaPR:Q9QUQ5 mTRPC4 PMID:11897792
GO:0016020 membranePR:Q9WVC5-1 mTRPC7/iso:1 PMID:10488066