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Protein Ontology report - cyclic nucleotide-gated channel alpha subunit
PR:000000673 - http://purl.obolibrary.org/obo/PR_000000673
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000673   
  PRO namecyclic nucleotide-gated channel alpha subunit 
  Definition"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. In addition, CNG alpha has a carboxy-terminal leucine zipper that seems to be involved in inter-subunit interaction. CNG alpha subunits combine with the beta subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however only alpha subunits are able to homooligomerize and form functional channels." [PMID:12432397, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000044648 cyclic nucleotide-regulated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 16                                        
         Sequence4                                                  Organism-Sequence 23                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002403
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000673 cyclic nucleotide-gated channel alpha subunit
CATSPERB

gene


PR:000000686 cyclic nucleotide-gated channel alpha-1
CNGA1

organism-gene


PR:P29973 cyclic nucleotide-gated channel alpha-1 (human)
hCNGA1

organism-sequence


PR:000000738 cyclic nucleotide-gated channel alpha-1 sequence variant S320F (human)
hCNGA1/var:S320F
Yes
organism-sequence


PR:P29973-1 cyclic nucleotide-gated channel alpha-1 isoform 1 (human)
hCNGA1/iso:1
Yes
organism-modification


PR:000078527 cyclic nucleotide-gated channel alpha-1 deaminated 1 (human)
hCNGA1/Deam:1

organism-gene


PR:P29974 cyclic nucleotide-gated channel alpha-1 (mouse)
mCNGA1
Yes
organism-sequence


PR:P29974-1 cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)
mCNGA1/iso:1

organism-gene


PR:Q00194 cyclic nucleotide-gated channel alpha-1 (cow)
cow-CNGA1

organism-sequence


PR:Q00194-1 cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)
cow-CNGA1/iso:1
Yes
organism-modification


PR:000036569 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)
cow-CNGA1/iso:1/Phos:1
Yes
organism-modification


PR:000045379 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)
cow-CNGA1/iso:1/Phos:2

organism-modification


PR:000045381 cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)
cow-CNGA1/iso:1/UnPhos:1
Yes
organism-gene


PR:Q62927 cyclic nucleotide-gated channel alpha-1 (rat)
rCNGA1

organism-gene


PR:Q90980 cyclic nucleotide-gated channel rod photoreceptor subunit alpha (chicken)
chick-CNGA1

sequence


PR:000000737 cyclic nucleotide-gated channel alpha-1 isoform 1
CNGA1/iso:1

organism-sequence


PR:P29973-1 cyclic nucleotide-gated channel alpha-1 isoform 1 (human)
hCNGA1/iso:1
Yes
organism-sequence


PR:P29974-1 cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)
mCNGA1/iso:1

organism-sequence


PR:Q00194-1 cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)
cow-CNGA1/iso:1
Yes
organism-modification


PR:000036569 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)
cow-CNGA1/iso:1/Phos:1
Yes
organism-modification


PR:000045379 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)
cow-CNGA1/iso:1/Phos:2

organism-modification


PR:000045381 cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)
cow-CNGA1/iso:1/UnPhos:1
Yes
modification


PR:000000932 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form
CNGA1/iso:1/PhosRes+

modification


PR:000000981 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1
CNGA1/iso:1/Phos:1

organism-modification


PR:000036569 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)
cow-CNGA1/iso:1/Phos:1
Yes
modification


PR:000045378 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2
CNGA1/iso:1/Phos:2

organism-modification


PR:000045379 cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)
cow-CNGA1/iso:1/Phos:2

gene


PR:000000696 cyclic nucleotide-gated channel alpha-3
CNGA3

organism-gene


PR:Q16281 cyclic nucleotide-gated channel alpha-3 (human)
hCNGA3

organism-sequence


PR:000000741 cyclic nucleotide-gated channel alpha-3 sequence variant R283Q (human)
hCNGA3/var:R283Q
Yes
organism-sequence


PR:000000742 cyclic nucleotide-gated channel alpha-3 sequence variant T291R (human)
hCNGA3/var:T291R
Yes
organism-sequence


PR:000000743 cyclic nucleotide-gated channel alpha-3 sequence variant G557R (human)
hCNGA3/var:G557R
Yes
organism-sequence


PR:000000744 cyclic nucleotide-gated channel alpha-3 sequence variant V529M (human)
hCNGA3/var:V529M
Yes
organism-sequence


PR:000000745 cyclic nucleotide-gated channel alpha-3 sequence variant R283W (human)
hCNGA3/var:R283W
Yes
organism-sequence


PR:000000746 cyclic nucleotide-gated channel alpha-3 sequence variant F547L (human)
hCNGA3/var:F547L
Yes
organism-sequence


PR:000000747 cyclic nucleotide-gated channel alpha-3 sequence variant R410W (human)
hCNGA3/var:R410W
Yes
organism-sequence


PR:000000748 cyclic nucleotide-gated channel alpha-3 sequence variant P163L (human)
hCNGA3/var:P163L
Yes
organism-sequence


PR:Q16281-1 cyclic nucleotide-gated channel alpha-3 isoform 1 (human)
hCNGA3/iso:1
Yes
organism-sequence


PR:Q16281-2 cyclic nucleotide-gated channel alpha-3 isoform h2 (human)
hCNGA3/iso:h2

organism-sequence


PR:Q16281-3 cyclic nucleotide-gated channel alpha-3 isoform h3 (human)
hCNGA3/iso:h3

organism-modification


PR:000081665 cyclic nucleotide-gated channel alpha-3 phosphorylated 1 (human)
hCNGA3/Phos:1

organism-gene


PR:Q90805 cyclic nucleotide-gated channel cone photoreceptor subunit alpha (chicken)
chick-CNGA3

organism-gene


PR:Q94A76 potassium channel GORK (Arabidopsis thaliana)
At-CNGA3

organism-gene


PR:Q9ER33 cyclic nucleotide-gated channel alpha-3 (rat)
rCNGA3

organism-sequence


PR:Q9ER33-1 cyclic nucleotide-gated channel alpha-3 isoform r1 (rat)
rCNGA3/iso:r1

organism-sequence


PR:Q9ER33-2 cyclic nucleotide-gated channel alpha-3 isoform r2 (rat)
rCNGA3/iso:r2

organism-gene


PR:Q9JJZ8 cyclic nucleotide-gated channel alpha-3 (mouse)
mCNGA3

organism-sequence


PR:Q9JJZ8-1 cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)
mCNGA3/iso:m1
Yes
sequence


PR:000000739 cyclic nucleotide-gated channel alpha-3 isoform 1
CNGA3/iso:1

organism-sequence


PR:Q16281-1 cyclic nucleotide-gated channel alpha-3 isoform 1 (human)
hCNGA3/iso:1
Yes
sequence


PR:000000740 cyclic nucleotide-gated channel alpha-3 isoform m1
CNGA3/iso:m1

organism-sequence


PR:Q9JJZ8-1 cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)
mCNGA3/iso:m1
Yes
gene


PR:000000698 cyclic nucleotide-gated channel alpha-2
CNGA2

organism-gene


PR:Q00195 cyclic nucleotide-gated channel alpha-2 (rat)
rCNGA2

organism-gene


PR:Q16280 cyclic nucleotide-gated channel alpha-2 (human)
hCNGA2

organism-gene


PR:Q62398 cyclic nucleotide-gated channel alpha-2 (mouse)
mCNGA2
Yes
gene


PR:000005631 cyclic nucleotide-gated channel alpha-4
CNGA4

organism-gene


PR:Q3UW12 cyclic nucleotide-gated channel alpha-4 (mouse)
mCNGA4

organism-sequence


PR:Q3UW12-1 cyclic nucleotide-gated channel alpha-4 isoform 1 (mouse)
mCNGA4/iso:1

organism-sequence


PR:Q3UW12-2 cyclic nucleotide-gated channel alpha-4 isoform m2 (mouse)
mCNGA4/iso:m2

organism-gene


PR:Q64359 cyclic nucleotide-gated channel alpha-4 (rat)
rCNGA4

organism-sequence


PR:Q64359-1 cyclic nucleotide-gated channel alpha-4 isoform 1 (rat)
rCNGA4/iso:1

organism-gene


PR:Q8IV77 cyclic nucleotide-gated channel alpha-4 (human)
hCNGA4

organism-sequence


PR:Q8IV77-1 cyclic nucleotide-gated channel alpha-4 isoform 1 (human)
hCNGA4/iso:1

organism-sequence


PR:Q8IV77-2 cyclic nucleotide-gated channel alpha-4 isoform h2 (human)
hCNGA4/iso:h2

sequence


PR:000041693 cyclic nucleotide-gated channel alpha-4 isoform 1
CNGA4/iso:1

organism-sequence


PR:Q3UW12-1 cyclic nucleotide-gated channel alpha-4 isoform 1 (mouse)
mCNGA4/iso:1

organism-sequence


PR:Q64359-1 cyclic nucleotide-gated channel alpha-4 isoform 1 (rat)
rCNGA4/iso:1

organism-sequence


PR:Q8IV77-1 cyclic nucleotide-gated channel alpha-4 isoform 1 (human)
hCNGA4/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000738 hCNGA1/var:S320F
Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997		 associated_with_disease_progressionDO:10584 retinitis pigmentosa PMID:7479749
located_inNOT GO:0005886 plasma membrane PMID:7479749
PR:000000741 hCNGA3/var:R283Q
Example: UniProtKB:Q16281-1, Arg-283, CHEBI:30011		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000742 hCNGA3/var:T291R
Example: UniProtKB:Q16281-1, Thr-291, CHEBI:29952		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000743 hCNGA3/var:G557R
Example: UniProtKB:Q16281-1, Gly-557, CHEBI:29952		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000744 hCNGA3/var:V529M
Example: UniProtKB:Q16281-1, Val-529, CHEBI:16044		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000745 hCNGA3/var:R283W
Example: UniProtKB:Q16281-1, Arg-283, CHEBI:29954		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000746 hCNGA3/var:F547L
Example: UniProtKB:Q16281-1, Phe-547, CHEBI:30006		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000747 hCNGA3/var:R410W
Example: UniProtKB:Q16281-1, Arg-410, CHEBI:29954		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000748 hCNGA3/var:P163L
Example: UniProtKB:Q16281-1, Pro-163, CHEBI:30006		 associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000036569 cow-CNGA1/iso:1/Phos:1
UniProtKB:Q00194-1, Tyr-498, MOD:00048		 enablesdecreased GO:0030553 cGMP binding relative to PR:000002593 PMID:10366613
PR:000045381 cow-CNGA1/iso:1/UnPhos:1
UniProtKB:Q00194-1, Tyr-498, PR:000026291		 enablesGO:0030553 cGMP binding PMID:10366613
PR:P29973-1 hCNGA1/iso:1 located_inGO:0005886 plasma membrane PMID:7479749
PR:P29974 mCNGA1 located_inGO:0001750 photoreceptor outer segment PMID:15634774
PR:Q00194-1 cow-CNGA1/iso:1 located_inGO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12432397; PMID:12467591
PR:Q16281-1 hCNGA3/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9517456
enablesGO:0015276 ligand-gated monoatomic ion channel activity PMID:9517456
located_inGO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12467591
PR:Q62398 mCNGA2 acts_upstream_of_or_withinGO:0007608 sensory perception of smell PMID:10798394
enablesGO:0005216 monoatomic ion channel activity PMID:10798394
PR:Q9JJZ8-1 mCNGA3/iso:m1 enablescontributes_to GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity PMID:10662822
located_inGO:0001750 photoreceptor outer segment PMID:10813773; PMID:15634774
GO:0032991 protein-containing complex PMID:10662822