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Protein Ontology report - smad3 isoform 1 phosphorylated 1
PR:000000658 - http://purl.obolibrary.org/obo/PR_000000658
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000658   
  PRO namesmad3 isoform 1 phosphorylated 1 
  Synonyms
PRO-Short-label: EXACT:SMAD3/iso:1/Phos:1
Other: EXACT:smad3 active
RELATED:TGF-beta receptor-activated smad3
  Definition"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the transforming growth factor beta signaling pathway. Example: UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PMID:8774881] 
  PRO Categorymodification 
  ParentPR:000000578 smad3 isoform 1 phosphorylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000000658 smad3 isoform 1 phosphorylated 1
SMAD3/iso:1/Phos:1

organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006366 transcription by RNA polymerase IIPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000026333 hSMAD3/iso:1/Phos:1 PMID:8774881; PMID:9380693

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886; PMID:12943993
GO:0003690 double-stranded DNA bindingPR:000036558 mSMAD3/iso:1/Phos:1 PMID:15282343
GO:0003700 DNA-binding transcription factor activityPR:000036558 mSMAD3/iso:1/Phos:1 PMID:10823886; PMID:12943993
GO:0008134 transcription factor bindingPR:000026333 hSMAD3/iso:1/Phos:1 PMID:15084259
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15464984; PMID:9702197
GO:0046332 SMAD bindingPR:000026333 hSMAD3/iso:1/Phos:1 PMID:15350224; PMID:9311995

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10846168; PMID:15280432
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:12943993; PMID:15282343
GO:0005667 transcription factor complexPR:000026333 hSMAD3/iso:1/Phos:1 PMID:12374795
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:9702197