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RACE-PRO
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Documentation
Protein Ontology report - TGF-beta 1 isoform 1 mature form
PR:000000616 -
http://purl.obolibrary.org/obo/PR_000000616
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000616
PRO name
TGF-beta 1 isoform 1 mature form
Synonyms
PRO-Short-label
:
EXACT:
TGFB1/iso:1/mature
Other
:
RELATED:
TGF-beta 1 active protein | TGF-beta 1 mature protein
Definition
"A TGF-beta 1 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature protein. Example:
UniProtKB:P01137-1
, 279-390." [
PMID:3162913
, PRO:CNA, PRO:DAN]
PRO Category
modification
Parent
PR:000000397
TGF-beta 1 isoform 1
PR:000018292
TGF-beta 1 proteolytic cleavage product
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000616
TGF-beta 1 isoform 1 mature form
TGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature protein. Example: UniProtKB:P01137-1, 279-390." [PMID:3162913, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]
Yes
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]
Yes
organism-modification
PR:000025929
TGF-beta 1 isoform 1 mature form (rat)
rTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]
Yes
Yes
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]
Yes
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TGFB1/iso:1/mature
forms found in complexes
TGFB1/iso:1/mature
Component
Complexes
PR:000000616
TGFB1/iso:1/mature
PR:000025925
dimeric TGF-beta 1
PR:000025927
hTGFB1/iso:1/mature
PR:000025926
dimeric TGF-beta 1 (human)
PR:000025929
rTGFB1/iso:1/mature
PR:000025931
dimeric TGF-beta 1 (rat)
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179
transforming growth factor beta receptor signaling pathway
PR:000025927
hTGFB1/iso:1/mature
PMID:8471846
PR:000025930
GrMonkey-TGFB1/iso:1/mature
PMID:3185545
GO:0030879
mammary gland development
PR:000025928
mTGFB1/iso:1/mature
PMID:1821856
GO:0043066
negative regulation of apoptotic process
PR:000025927
hTGFB1/iso:1/mature
PMID:9918798
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005160
transforming growth factor beta receptor binding
PR:000025928
mTGFB1/iso:1/mature
PMID:14764882
GO:0042803
protein homodimerization activity
PR:000025927
hTGFB1/iso:1/mature
PMID:3162913
;
PMID:8471846
PR:000025930
GrMonkey-TGFB1/iso:1/mature
PMID:3185545
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0031012
extracellular matrix
PR:000025927
hTGFB1/iso:1/mature
PMID:8294500
PR:000025928
mTGFB1/iso:1/mature
PMID:9008713
PR:000025929
rTGFB1/iso:1/mature
PMID:11907708
PR:000025930
GrMonkey-TGFB1/iso:1/mature
PMID:3185545
