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RACE-PRO
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Documentation
Protein Ontology report - tumor necrosis factor isoform 1 cleaved 1
PR:000000604 -
http://purl.obolibrary.org/obo/PR_000000604
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000604
PRO name
tumor necrosis factor isoform 1 cleaved 1
Synonyms
PRO-Short-label
:
EXACT:
TNF/iso:1/Clv:1
Other
:
EXACT:
tumor necrosis factor soluble form
Definition
"A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [
PMID:12135369
]
PRO Category
modification
Parent
PR:000000381
tumor necrosis factor isoform 1
PR:000018285
tumor necrosis factor proteolytic cleavage product
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000604
tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1
organism-modification
PR:000036504
tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification
PR:000036505
tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
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Functional Annotation (GO-centric view)
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PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006355
regulation of DNA-templated transcription
PR:000036505
mTNF/iso:1/Clv:1
PMID:9305915
GO:0006915
apoptotic process
PR:000036504
hTNF/iso:1/Clv:1
PMID:3856324
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005164
tumor necrosis factor receptor binding
PR:000036504
hTNF/iso:1/Clv:1
PMID:14512626
GO:0042802
identical protein binding
PR:000036504
hTNF/iso:1/Clv:1
PMID:14512626
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615
extracellular space
PR:000036505
mTNF/iso:1/Clv:1
PMID:10089307
