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Protein Ontology report - smad1 isoform 1

PR:000000467 - http://purl.obolibrary.org/obo/PR_000000467

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000467

PRO name

smad1 isoform 1

Synonyms

PRO-Short-label:

EXACT:

SMAD1/iso:1

Definition

"A smad1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

PRO Category

sequence

Parent

PR:000000363 smad1

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	2
Modification	4	Organism-Modification	3

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000000467 smad1 isoform 1

SMAD1/iso:1

organism-sequence

PR:P70340-1 mothers against decapentaplegic homolog 1 isoform 1 (mouse)

mSMAD1/iso:1

Yes

organism-modification

PR:000026724 smad1 isoform 1 phosphorylated 1 (mouse)

mSMAD1/iso:1/Phos:1

Yes

organism-sequence

PR:Q15797-1 mothers against decapentaplegic homolog 1 isoform 1 (human)

hSMAD1/iso:1

Yes

organism-modification

PR:000026334 smad1 isoform 1 phosphorylated 1 (human)

hSMAD1/iso:1/Phos:1

Yes

organism-modification

PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1

Yes

modification

PR:000000570 smad1 isoform 1 phosphorylated and ubiquitinated form

SMAD1/iso:1/PhosUbiq+

modification

PR:000000648 smad1 isoform 1 phosphorylated and ubiquitinated 1

SMAD1/iso:1/PhosUbiq:1

organism-modification

PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1

Yes

modification

PR:000000571 smad1 isoform 1 phosphorylated form

SMAD1/iso:1/PhosRes+

modification

PR:000000570 smad1 isoform 1 phosphorylated and ubiquitinated form

SMAD1/iso:1/PhosUbiq+

modification

PR:000000648 smad1 isoform 1 phosphorylated and ubiquitinated 1

SMAD1/iso:1/PhosUbiq:1

organism-modification

PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1

Yes

modification

PR:000000647 smad1 isoform 1 phosphorylated 1

SMAD1/iso:1/Phos:1

Yes

organism-modification

PR:000026334 smad1 isoform 1 phosphorylated 1 (human)

hSMAD1/iso:1/Phos:1

Yes

organism-modification

PR:000026724 smad1 isoform 1 phosphorylated 1 (mouse)

mSMAD1/iso:1/Phos:1

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000647 SMAD1/iso:1/Phos:1 Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046	enables	GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:10708949
PR:000026334 hSMAD1/iso:1/Phos:1 UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046	acts_upstream_of_or_within	GO:0007165 signal transduction	PMID:9759503
	acts_upstream_of_or_within	GO:0030509 BMP signaling pathway	PMID:8653785
	enables	GO:0046332 SMAD binding with PR:Q13485 deletion target in pancreatic carcinoma 4 (human)	PMID:9136927
	located_in	GO:0005634 nucleus	PMID:11509558; PMID:9759503
PR:000026724 mSMAD1/iso:1/Phos:1 UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:15899870
	acts_upstream_of_or_within	GO:0030509 BMP signaling pathway	PMID:12370310; PMID:15198985
	enables	GO:0005515 protein binding with PR:Q04211 BTG family member 2 (mouse)	PMID:14633973
		GO:0005515 protein binding with PR:Q8BGV5 mZNF8	PMID:14633973
		GO:0005515 protein binding with PR:Q9QZH6 Ecsit	PMID:14633973
	located_in	GO:0005634 nucleus	PMID:10504300; PMID:12151307; PMID:12370310
		GO:0005667 transcription factor complex	PMID:14633973
		GO:0005769 early endosome	PMID:17592637
PR:000036553 hSMAD1/iso:1/PhosUbiq:1 UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046\|MOD:01148	acts_upstream_of_or_within	GO:0030514 negative regulation of BMP signaling pathway	PMID:12857866
PR:P70340-1 mSMAD1/iso:1	acts_upstream_of_or_within	GO:0030509 BMP signaling pathway	PMID:15198985; PMID:15331632; PMID:17356069
PR:P70340-1 mSMAD1/iso:1	located_in	GO:0005737 cytoplasm	PMID:10504300; PMID:17356069
PR:Q15797-1 hSMAD1/iso:1	acts_upstream_of_or_within	GO:0007165 signal transduction	PMID:8637600
	acts_upstream_of_or_within	GO:0030509 BMP signaling pathway	PMID:8653785
	enables	GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:10708949
		GO:0005102 signaling receptor binding	PMID:9136927; PMID:9748228
		GO:0005515 protein binding	PMID:17356069
	located_in	GO:0005737 cytoplasm	PMID:11509558