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Protein Ontology report - TGF-beta 1 isoform 1
PR:000000397 - http://purl.obolibrary.org/obo/PR_000000397
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000397   
  PRO nameTGF-beta 1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:TGFB1/iso:1
  Definition"A TGF-beta 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01137-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000182 TGF-beta 1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000397 TGF-beta 1 isoform 1
TGFB1/iso:1

organism-sequence


PR:P01137-1 transforming growth factor beta-1 isoform 1 (human)
hTGFB1/iso:1
Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
organism-sequence


PR:P04202-1 transforming growth factor beta-1 isoform 1 (mouse)
mTGFB1/iso:1
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
organism-sequence


PR:P09533-1 transforming growth factor beta-1 isoform 1 (green monkey)
GrMonkey-TGFB1/iso:1

organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
modification


PR:000000616 TGF-beta 1 isoform 1 mature form
TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat)
rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
Yes
modification


PR:000002555 TGF-beta 1 isoform 1 unmodified form
TGFB1/iso:1/UnMod

modification


PR:000025454 TGF-beta 1 isoform 1, signal peptide removed form
TGFB1/iso:1/SigPep-

modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide
TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
modification


PR:000000618 TGF-beta 1 isoform 1 inactive form
TGFB1/iso:1/inactive

organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
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TGFB1/iso:1 forms found in complexes   

TGFB1/iso:1 Component
 Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925 dimeric TGF-beta 1
PR:000025927 hTGFB1/iso:1/mature PR:000025926 dimeric TGF-beta 1 (human)
PR:000025929 rTGFB1/iso:1/mature PR:000025931 dimeric TGF-beta 1 (rat)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000025927 hTGFB1/iso:1/mature PMID:8471846
PR:000025930 GrMonkey-TGFB1/iso:1/mature PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive PMID:1448117; PMID:2677679
PR:P01137-1 hTGFB1/iso:1 PMID:1544940
GO:0030879 mammary gland developmentPR:000025928 mTGFB1/iso:1/mature PMID:1821856
PR:000036529 mTGFB1/iso:1/inactive PMID:1821856
PR:P04202-1 mTGFB1/iso:1 PMID:1821856
GO:0043066 negative regulation of apoptotic processPR:000025927 hTGFB1/iso:1/mature PMID:9918798
PR:P01137-1 hTGFB1/iso:1 PMID:9918798

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005160 transforming growth factor beta receptor bindingPR:000025928 mTGFB1/iso:1/mature PMID:14764882
NOT GO:0005160 transforming growth factor beta receptor bindingPR:000026335 hTGFB1/iso:1/inactive PMID:2677679; PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive PMID:1448117
GO:0042803 protein homodimerization activityPR:000025927 hTGFB1/iso:1/mature PMID:3162913; PMID:8471846
PR:000025930 GrMonkey-TGFB1/iso:1/mature PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive PMID:3162913
PR:P01137-1 hTGFB1/iso:1 PMID:1544940

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005796 Golgi lumenPR:P01137-1 hTGFB1/iso:1 PMID:1544940
GO:0031012 extracellular matrixPR:000025927 hTGFB1/iso:1/mature PMID:8294500
PR:000025928 mTGFB1/iso:1/mature PMID:9008713
PR:000025929 rTGFB1/iso:1/mature PMID:11907708
PR:000025930 GrMonkey-TGFB1/iso:1/mature PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive PMID:17015622; PMID:8294500
PR:000036529 mTGFB1/iso:1/inactive PMID:9008713
GO:0032991 protein-containing complexPR:000026335 hTGFB1/iso:1/inactive PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP PMID:17015622; PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive PMID:1448117; PMID:2677679