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Protein Ontology report - smad6
PR:000000373 - http://purl.obolibrary.org/obo/PR_000000373
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000373   
  PRO namesmad6 
  Synonyms
PRO-Short-label: EXACT:SMAD6
Gene-based: RELATED:MADH6 | Madh7 | Msmad6
Other: EXACT:MAD homolog 6 | Mad homolog 7 | mothers against DPP homolog 6 | SMAD 6 | SMAD family member 6
  Definition"An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6." [PMID:17493940
  PRO Categorygene 
  ParentPR:000000099 inhibitory smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000373

smad6

SMAD6


"An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6." [PMID:17493940]


organism-gene



PR:O35182

mothers against decapentaplegic homolog 6 (mouse)

mSMAD6


"A smad6 that is encoded in the genome of mouse." [OMA:O35182, PRO:DNx]


organism-sequence



PR:O35182-1

mothers against decapentaplegic homolog 6 isoform 1 (mouse)

mSMAD6/iso:1


"A smad6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036564

smad6 isoform 1 dimethylated 1 (mouse)

mSMAD6/iso:1/Me2:1


"A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]

Yes

organism-gene



PR:O43541

mothers against decapentaplegic homolog 6 (human)

hSMAD6


"A smad6 that is encoded in the genome of human." []


organism-sequence



PR:O43541-1

mothers against decapentaplegic homolog 6 isoform A (human)

hSMAD6/iso:A


"A smad6 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O43541-2

mothers against decapentaplegic homolog 6 isoform B (human)

hSMAD6/iso:B


"A smad6 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O43541-4

mothers against decapentaplegic homolog 6 isoform D (human)

hSMAD6/iso:D


"A mothers against decapentaplegic homolog 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-4." [PRO:DNx, UniProtKB:O43541]


organism-gene



PR:Q9W734

mothers against decapentaplegic homolog 6 (chicken)

chick-SMAD6


"A smad6 that is encoded in the genome of chicken." [OMA:Q9W734, PRO:DNx]


sequence



PR:000000479

smad6 isoform 1

SMAD6/iso:1


"A smad6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O35182-1

mothers against decapentaplegic homolog 6 isoform 1 (mouse)

mSMAD6/iso:1


"A smad6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036564

smad6 isoform 1 dimethylated 1 (mouse)

mSMAD6/iso:1/Me2:1


"A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]

Yes

organism-sequence



PR:O43541-1

mothers against decapentaplegic homolog 6 isoform A (human)

hSMAD6/iso:A


"A smad6 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

modification



PR:000000581

smad6 isoform 1 dimethylated form

SMAD6/iso:1/Me2Res+


"A smad6 isoform 1 that includes at least one dimethylated residue." [PRO:CNA]


modification



PR:000000662

smad6 isoform 1 dimethylated 1

SMAD6/iso:1/Me2:1


"A smad6 isoform 1 dimethylated form that has been dimethylated at Arg residues within the MH1 domain by PRMT1. Example: UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358]


organism-modification



PR:000036564

smad6 isoform 1 dimethylated 1 (mouse)

mSMAD6/iso:1/Me2:1


"A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]

Yes

sequence



PR:000000480

smad6 isoform 2

SMAD6/iso:2


"A smad6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-2 or a 1:1 ortholog thereof." [PMID:11284962, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43541-2

mothers against decapentaplegic homolog 6 isoform B (human)

hSMAD6/iso:B


"A smad6 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005515 protein bindingPR:O43541-1 hSMAD6/iso:A PMID:9436979
PR:O43541-2 hSMAD6/iso:B PMID:11284962
GO:0140416 transcription regulator inhibitor activityPR:000036564 mSMAD6/iso:1/Me2:1 PMID:17118358
PR:O35182-1 mSMAD6/iso:1 PMID:17118358
PR:O43541-1 hSMAD6/iso:A PMID:9436979
PR:O43541-2 hSMAD6/iso:B PMID:11284962