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Protein Ontology report - smad6
PR:000000373 - http://purl.obolibrary.org/obo/PR_000000373
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000373   
  PRO namesmad6 
  Synonyms
PRO-Short-label: EXACT:SMAD6
Gene-based: RELATED:MADH6 | Madh7 | Msmad6
Other: EXACT:MAD homolog 6 | Mad homolog 7 | mothers against DPP homolog 6 | SMAD 6 | SMAD family member 6
  Definition"An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6." [PMID:17493940] 
  PRO Categorygene 
  ParentPR:000000099 inhibitory smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000373 smad6
SMAD6

organism-gene


PR:O35182 mothers against decapentaplegic homolog 6 (mouse)
mSMAD6

organism-sequence


PR:O35182-1 mothers against decapentaplegic homolog 6 isoform 1 (mouse)
mSMAD6/iso:1
Yes
organism-modification


PR:000036564 smad6 isoform 1 dimethylated 1 (mouse)
mSMAD6/iso:1/Me2:1
Yes
organism-gene


PR:O43541 mothers against decapentaplegic homolog 6 (human)
hSMAD6

organism-sequence


PR:O43541-1 mothers against decapentaplegic homolog 6 isoform A (human)
hSMAD6/iso:A
Yes
organism-sequence


PR:O43541-2 mothers against decapentaplegic homolog 6 isoform B (human)
hSMAD6/iso:B
Yes
organism-sequence


PR:O43541-4 mothers against decapentaplegic homolog 6 isoform D (human)
hSMAD6/iso:D

organism-gene


PR:Q9W734 mothers against decapentaplegic homolog 6 (chicken)
chick-SMAD6

sequence


PR:000000479 smad6 isoform 1
SMAD6/iso:1

organism-sequence


PR:O35182-1 mothers against decapentaplegic homolog 6 isoform 1 (mouse)
mSMAD6/iso:1
Yes
organism-modification


PR:000036564 smad6 isoform 1 dimethylated 1 (mouse)
mSMAD6/iso:1/Me2:1
Yes
organism-sequence


PR:O43541-1 mothers against decapentaplegic homolog 6 isoform A (human)
hSMAD6/iso:A
Yes
modification


PR:000000581 smad6 isoform 1 dimethylated form
SMAD6/iso:1/Me2Res+

modification


PR:000000662 smad6 isoform 1 dimethylated 1
SMAD6/iso:1/Me2:1

organism-modification


PR:000036564 smad6 isoform 1 dimethylated 1 (mouse)
mSMAD6/iso:1/Me2:1
Yes
sequence


PR:000000480 smad6 isoform 2
SMAD6/iso:2

organism-sequence


PR:O43541-2 mothers against decapentaplegic homolog 6 isoform B (human)
hSMAD6/iso:B
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036564 mSMAD6/iso:1/Me2:1
UniProtKB:O35182-1, Arg-74, MOD:00783		 enablesGO:0140416 transcription regulator inhibitor activity PMID:17118358
PR:O35182-1 mSMAD6/iso:1 enablesGO:0140416 transcription regulator inhibitor activity PMID:17118358
PR:O43541-1 hSMAD6/iso:A enablesGO:0005515 protein binding with PR:000026334 hSMAD1/iso:1/Phos:1 PMID:9436979
GO:0140416 transcription regulator inhibitor activity PMID:9436979
PR:O43541-2 hSMAD6/iso:B enablesGO:0005515 protein binding PMID:11284962
GO:0140416 transcription regulator inhibitor activity PMID:11284962