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Protein Ontology report - smad2
PR:000000364 - http://purl.obolibrary.org/obo/PR_000000364
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000364   
  PRO namesmad2 
  Synonyms
PRO-Short-label: EXACT:SMAD2
Gene-based: RELATED:MADH2 | MADR2
Other: EXACT:JV18-1 | MAD homolog 2 | MAD-2 | Mad-related protein 2 | Mad2 | mothers against DPP homolog 2 | SMAD 2 | SMAD family member 2
  Definition"A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD2 gene or a 1:1 ortholog thereof." [PMID:9311995] 
  PRO Categorygene 
  ParentPR:000000066 TGF-beta receptor-regulated smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence2                                                  Organism-Sequence 9                                        
         Modification20                                                  Organism-Modification 32                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000364 smad2
SMAD2

organism-gene


PR:O70436 mothers against decapentaplegic homolog 2 (rat)
rSMAD2

organism-gene


PR:P45896 dwarfin sma-3 (worm)
SMAD2 (worm)

organism-gene


PR:Q15796 mothers against decapentaplegic homolog 2 (human)
hSMAD2

organism-sequence


PR:000000470 smad2 sequence variant R133C (human)
hSMAD2/var:R133C
Yes
organism-sequence


PR:000000471 smad2 sequence variant L440R (human)
hSMAD2/var:L440R
Yes
organism-sequence


PR:000000472 smad2 sequence variant P445H (human)
hSMAD2/var:P445H
Yes
organism-sequence


PR:000000473 smad2 sequence variant D450E (human)
hSMAD2/var:D450E
Yes
organism-sequence


PR:000000474 smad2 sequence variant 5 (human)
hSMAD2/var:5
Yes
organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000025960 smad2 isoform unphosphorylated 1 (human)
hSMAD2/iso:[Long/Short]/UnPhos:1

organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1

organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human)
hSMAD2/InitMet-

organism-modification


PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human)
hSMAD2/InitMet-/Phos:1

organism-modification


PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human)
hSMAD2/InitMet-/Phos:5

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000060357 mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300A/InitMet-/Phos:1

organism-modification


PR:000060522 mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human)
hSMAD2/var:S464L/InitMet-

organism-modification


PR:000060657 mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300V/InitMet-/Phos:1

organism-modification


PR:000060862 mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300N/InitMet-/Phos:1

organism-modification


PR:000061944 mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:A354T/InitMet-/Phos:1

organism-modification


PR:000062120 mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305Q/InitMet-/Phos:1

organism-modification


PR:000062419 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human)
hSMAD2/InitMet-/Phos:2

organism-modification


PR:000063661 mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human)
hSMAD2/var:S464*/InitMet-

organism-modification


PR:000063912 mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human)
hSMAD2/var:S467P/InitMet-

organism-modification


PR:000064349 mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305L/InitMet-/Phos:1

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000050145 smad2 phosphorylated 1 (human)
hSMAD2/Phos:1

organism-modification


PR:000065797 mothers against decapentaplegic homolog 2 methylated 1 (human)
hSMAD2/Me:1

organism-modification


PR:000077056 mothers against decapentaplegic homolog 2 cysteinylated 1 (human)
hSMAD2/Cyst:1

organism-gene


PR:Q62432 mothers against decapentaplegic homolog 2 (mouse)
mSMAD2

organism-sequence


PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse)
mSMAD2/iso:Long
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-sequence


PR:Q62432-2 mothers against decapentaplegic homolog 2 isoform Short (mouse)
mSMAD2/iso:Short

organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
organism-gene


PR:Q9I9P9 mothers against decapentaplegic homolog 2 (zebrafish)
z-SMAD2

sequence


PR:000000468 smad2 isoform Long
SMAD2/iso:Long

organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse)
mSMAD2/iso:Long
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000572 smad2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+

modification


PR:000000649 smad2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 smad2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 smad2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000574 smad2 isoform Long phosphorylated form
SMAD2/iso:Long/PhosRes+

modification


PR:000000572 smad2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+

modification


PR:000000649 smad2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 smad2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 smad2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000650 smad2 isoform Long phosphorylated 1
SMAD2/iso:Long/Phos:1

Yes
organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
modification


PR:000000651 smad2 isoform Long phosphorylated 2
SMAD2/iso:Long/Phos:2

Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
modification


PR:000000652 smad2 isoform Long phosphorylated 3
SMAD2/iso:Long/Phos:3

Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
modification


PR:000000653 smad2 isoform Long phosphorylated 4
SMAD2/iso:Long/Phos:4

organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
modification


PR:000002570 smad2 isoform Long unmodified form
SMAD2/iso:Long/UnMod

Yes
modification


PR:000026718 smad2 isoform Long, initiator methionine removed form
SMAD2/iso:Long/InitMet-

sequence


PR:000000469 smad2 isoform Short
SMAD2/iso:Short

organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-sequence


PR:Q62432-2 mothers against decapentaplegic homolog 2 isoform Short (mouse)
mSMAD2/iso:Short

organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form
SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1
SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000576 smad2 isoform Short phosphorylated form
SMAD2/iso:Short/PhosRes+

modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form
SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1
SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000656 smad2 isoform Short phosphorylated 1
SMAD2/iso:Short/Phos:1

Yes
organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000002571 smad2 isoform Short unmodified form
SMAD2/iso:Short/UnMod

modification


PR:000018296 smad2, initiator methionine removed form
SMAD2/InitMet-

modification


PR:000026718 smad2 isoform Long, initiator methionine removed form
SMAD2/iso:Long/InitMet-

organism-modification


PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human)
hSMAD2/InitMet-

organism-modification


PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human)
hSMAD2/InitMet-/Phos:1

organism-modification


PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human)
hSMAD2/InitMet-/Phos:5

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000060357 mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300A/InitMet-/Phos:1

organism-modification


PR:000060522 mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human)
hSMAD2/var:S464L/InitMet-

organism-modification


PR:000060657 mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300V/InitMet-/Phos:1

organism-modification


PR:000060862 mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300N/InitMet-/Phos:1

organism-modification


PR:000061944 mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:A354T/InitMet-/Phos:1

organism-modification


PR:000062120 mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305Q/InitMet-/Phos:1

organism-modification


PR:000062419 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human)
hSMAD2/InitMet-/Phos:2

organism-modification


PR:000063661 mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human)
hSMAD2/var:S464*/InitMet-

organism-modification


PR:000063912 mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human)
hSMAD2/var:S467P/InitMet-

organism-modification


PR:000064349 mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305L/InitMet-/Phos:1

modification


PR:000028327 smad2 unmodified form
SMAD2/UnMod

modification


PR:000002570 smad2 isoform Long unmodified form
SMAD2/iso:Long/UnMod

Yes
modification


PR:000002571 smad2 isoform Short unmodified form
SMAD2/iso:Short/UnMod

modification


PR:000025973 smad2 isoform unmodified form
SMAD2/iso:[Long/Short]/UnMod

Yes
modification


PR:000002570 smad2 isoform Long unmodified form
SMAD2/iso:Long/UnMod

modification


PR:000002571 smad2 isoform Short unmodified form
SMAD2/iso:Short/UnMod

modification


PR:000050146 smad2 phosphorylated 1
SMAD2/Phos:1

organism-modification


PR:000050145 smad2 phosphorylated 1 (human)
hSMAD2/Phos:1

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SMAD2 forms found in complexes   

SMAD2 Component
 Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025971 smad2-smad4-ski protein complex 1
PR:000000651 SMAD2/iso:Long/Phos:2 PR:000025969 smad2-smad4 protein complex 3
PR:000000652 SMAD2/iso:Long/Phos:3 PR:000025970 smad2-smad4 protein complex 4
PR:000000656 SMAD2/iso:Short/Phos:1 PR:000025968 smad2-smad4 protein complex 2
PR:000002570 SMAD2/iso:Long/UnMod PR:000025972 smad2-smad4-ski protein complex 2
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000025943 mSMAD2/iso:Short/Phos:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
PR:000025973 SMAD2/iso:[Long/Short]/UnMod PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000470 hSMAD2/var:R133C
Example: UniProtKB:Q15796-1, Arg-133, CHEBI:29950		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8752209
associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000471 hSMAD2/var:L440R
Example: UniProtKB:Q15796-1, Leu-440, CHEBI:29952		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
PR:000000472 hSMAD2/var:P445H
Example: UniProtKB:Q15796-1, Pro-445, CHEBI:29979		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000473 hSMAD2/var:D450E
Example: UniProtKB:Q15796-1, Asp-450, CHEBI:29972		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000474 hSMAD2/var:5
Example: UniProtKB:Q15796-1, 2-343, 359-467		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8673135
enablesNOT GO:0003713 transcription coactivator activity PMID:8673135
PR:000025934 hSMAD2/iso:Long/Phos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:15690394; PMID:9689110
GO:0007165 signal transduction PMID:8752209; PMID:8980228; PMID:9346966
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209; PMID:8980228
GO:0060395 SMAD protein signal transduction PMID:9346966
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228; PMID:9346966
GO:0003713 transcription coactivator activity PMID:9689110
GO:0046332 SMAD binding PMID:9311995
located_inGO:0005634 nucleus PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12193595
GO:0007165 signal transduction PMID:12193595
GO:0060395 SMAD protein signal transduction PMID:12193595
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595
GO:0003712 transcription coregulator activity PMID:12193595
GO:0046332 SMAD binding PMID:12193595
located_inGO:0005634 nucleus PMID:12193595; PMID:17074053
PR:000025936 hSMAD2/iso:Long/Phos:3
UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11027280
GO:0060395 SMAD protein signal transduction PMID:11027280
enablesNOT GO:0003713 transcription coactivator activity PMID:11027280
GO:0046332 SMAD binding PMID:11027280
located_inGO:0005737 cytoplasm PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4
UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:000025938 hSMAD2/iso:Short/Phos:1
UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
enablesGO:0003677 DNA binding PMID:14701940; PMID:9873005
GO:0003700 DNA-binding transcription factor activity PMID:9873005
GO:0003712 transcription coregulator activity PMID:14701940; PMID:9873005
PR:000025942 mSMAD2/iso:Long/Phos:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11262418
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11262418
enablesGO:0003713 transcription coactivator activity PMID:15282343
GO:0046332 SMAD binding PMID:11043574
located_inGO:0005634 nucleus PMID:11557747
PR:000025943 mSMAD2/iso:Short/Phos:1
UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:15630024
enablesGO:0003700 DNA-binding transcription factor activity PMID:15630024
PR:000036554 hSMAD2/iso:Long/AcPhos:1
UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:17074756
GO:0007165 signal transduction PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:15496141
enablesNOT GO:0003713 transcription coactivator activity PMID:15496141
PR:000036556 hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003677 DNA binding PMID:17074756
increased GO:0003700 DNA-binding transcription factor activity relative to PR:000000656 SMAD2/iso:Short/Phos:1 PMID:17074756
PR:000045371 hSMAD2/iso:Long/UnPhos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
enablesGO:0005515 protein binding PMID:8980228
located_inGO:0005737 cytoplasm PMID:15280432; PMID:17074053
GO:0005769 early endosome PMID:12356868
PR:Q62432-1 mSMAD2/iso:Long acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11557747
located_inGO:0005737 cytoplasm PMID:14701940