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Protein Ontology report - smad1
PR:000000363 - http://purl.obolibrary.org/obo/PR_000000363
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000363   
  PRO namesmad1 
  Synonyms
PRO-Short-label: EXACT:SMAD1
Gene-based: RELATED:BSP1 | MADH1 | MADR1
Other: EXACT:BSP-1 | dwarfin-A | Dwf-A | JV4-1 | MAD homolog 1 | Mad-related protein 1 | Mad1 | mothers against DPP homolog 1 | mothers-against-DPP-related 1 | SMAD 1 | SMAD family member 1 | transforming growth factor-beta-signaling protein 1
  Definition"A BMP receptor-regulated smad protein that is a translation product of the human SMAD1 gene or a 1:1 ortholog thereof." [PMID:10708949, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000038 BMP receptor-regulated smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000363
smad1
SMAD1
"A BMP receptor-regulated smad protein that is a translation product of the human SMAD1 gene or a 1:1 ortholog thereof." [PMID:10708949, PRO:CNA]

organism-gene


PR:P70340
mothers against decapentaplegic homolog 1 (mouse)
mSMAD1
"A smad1 that is encoded in the genome of mouse." [OMA:P70340, PRO:DNx]

organism-sequence


PR:P70340-1
mothers against decapentaplegic homolog 1 isoform 1 (mouse)
mSMAD1/iso:1
"A smad1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000026724
smad1 isoform 1 phosphorylated 1 (mouse)
mSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]
Yes
organism-gene


PR:P97588
mothers against decapentaplegic homolog 1 (rat)
rSMAD1
"A smad1 that is encoded in the genome of rat." [OMA:P97588, PRO:DNx]

organism-gene


PR:Q15797
mothers against decapentaplegic homolog 1 (human)
hSMAD1
"A smad1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q15797]

organism-sequence


PR:Q15797-1
mothers against decapentaplegic homolog 1 isoform 1 (human)
hSMAD1/iso:1
"A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000026334
smad1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]
Yes
organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:Q15797-2
mothers against decapentaplegic homolog 1 isoform h2 (human)
hSMAD1/iso:h2
"A mothers against decapentaplegic homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-2." [PRO:DNx, UniProtKB:Q15797]

organism-modification


PR:000049280
mothers against decapentaplegic homolog 1 ubiquitinated form (human)
hSMAD1/UbiqLys+
"A mothers against decapentaplegic homolog 1 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q15797, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782768]

organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000050147
smad1 phosphorylated 1 (human)
hSMAD1/Phos:1
"A smad1 phosphorylated 1 in human. UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]

sequence


PR:000000467
smad1 isoform 1
SMAD1/iso:1
"A smad1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P70340-1
mothers against decapentaplegic homolog 1 isoform 1 (mouse)
mSMAD1/iso:1
"A smad1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000026724
smad1 isoform 1 phosphorylated 1 (mouse)
mSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]
Yes
organism-sequence


PR:Q15797-1
mothers against decapentaplegic homolog 1 isoform 1 (human)
hSMAD1/iso:1
"A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000026334
smad1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]
Yes
organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000570
smad1 isoform 1 phosphorylated and ubiquitinated form
SMAD1/iso:1/PhosUbiq+
"A smad1 isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000000648
smad1 isoform 1 phosphorylated and ubiquitinated 1
SMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated at the two last C-terminal SSxS motif and has been ubiquitinated by E3 ubiquitin-protein ligase SMURF1 (PR:000000466). Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000571
smad1 isoform 1 phosphorylated form
SMAD1/iso:1/PhosRes+
"A smad1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000570
smad1 isoform 1 phosphorylated and ubiquitinated form
SMAD1/iso:1/PhosUbiq+
"A smad1 isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000000648
smad1 isoform 1 phosphorylated and ubiquitinated 1
SMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated at the two last C-terminal SSxS motif and has been ubiquitinated by E3 ubiquitin-protein ligase SMURF1 (PR:000000466). Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000647
smad1 isoform 1 phosphorylated 1
SMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PMID:9136927]
Yes
organism-modification


PR:000026334
smad1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]
Yes
organism-modification


PR:000026724
smad1 isoform 1 phosphorylated 1 (mouse)
mSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]
Yes
modification


PR:000050148
smad1 phosphorylated 1
SMAD1/Phos:1
"A smad1 that has been phosphorylated on the last two Ser residues within the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]

organism-modification


PR:000050147
smad1 phosphorylated 1 (human)
hSMAD1/Phos:1
"A smad1 phosphorylated 1 in human. UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000647 SMAD1/iso:1/Phos:1
Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046		 enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
PR:000026334 hSMAD1/iso:1/Phos:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9759503
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0046332 SMAD binding with PR:Q13485 deletion target in pancreatic carcinoma 4 (human) PMID:9136927
located_inGO:0005634 nucleus PMID:11509558; PMID:9759503
PR:000026724 mSMAD1/iso:1/Phos:1
UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15899870
GO:0030509 BMP signaling pathway PMID:12370310; PMID:15198985
enablesGO:0005515 protein binding with PR:Q04211 BTG family member 2 (mouse) PMID:14633973
GO:0005515 protein binding with PR:Q8BGV5 mZNF8 PMID:14633973
GO:0005515 protein binding with PR:Q9QZH6 Ecsit PMID:14633973
located_inGO:0005634 nucleus PMID:10504300; PMID:12151307; PMID:12370310
GO:0005667 transcription factor complex PMID:14633973
GO:0005769 early endosome PMID:17592637
PR:000036553 hSMAD1/iso:1/PhosUbiq:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:12857866
PR:P70340-1 mSMAD1/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:15198985; PMID:15331632; PMID:17356069
located_inGO:0005737 cytoplasm PMID:10504300; PMID:17356069
PR:Q15797-1 hSMAD1/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8637600
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
GO:0005102 signaling receptor binding PMID:9136927; PMID:9748228
GO:0005515 protein binding PMID:17356069
located_inGO:0005737 cytoplasm PMID:11509558