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Protein Ontology report - E3 ubiquitin-protein ligase SMURF1
PR:000000361 - http://purl.obolibrary.org/obo/PR_000000361
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000361   
  PRO nameE3 ubiquitin-protein ligase SMURF1 
  Synonyms
PRO-Short-label: EXACT:SMURF1
Gene-based: RELATED:KIAA1625
Other: EXACT:HECT-type E3 ubiquitin transferase SMURF1 | SMAD ubiquitination regulatory factor 1 | smad ubiquitination regulatory factor 1 | SMAD-specific E3 ubiquitin-protein ligase 1
  Definition"A smad ubiquitination regulatory factor that is a translation product of the human SMURF1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000127 smad ubiquitination regulatory factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000361 E3 ubiquitin-protein ligase SMURF1
SMURF1

organism-gene


PR:Q9CUN6 E3 ubiquitin-protein ligase SMURF1 (mouse)
mSMURF1
Yes
organism-sequence


PR:Q9CUN6-1 E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)
mSMURF1/iso:Short
Yes
organism-modification


PR:000049754 E3 ubiquitin-protein ligase SMURF1 phosphorylated 1 (mouse)
mSMURF1/Phos:1

organism-modification


PR:000049755 E3 ubiquitin-protein ligase SMURF1 unphosphorylated 1 (mouse)
mSMURF1/UnPhos:1

organism-gene


PR:Q9HCE7 E3 ubiquitin-protein ligase SMURF1 (human)
hSMURF1
Yes
organism-sequence


PR:Q9HCE7-1 E3 ubiquitin-protein ligase SMURF1 isoform Long (human)
hSMURF1/iso:Long

organism-sequence


PR:Q9HCE7-2 E3 ubiquitin-protein ligase SMURF1 isoform Short (human)
hSMURF1/iso:Short
Yes
organism-modification


PR:000075773 E3 ubiquitin-protein ligase SMURF1 cysteinylated 1 (human)
hSMURF1/Cyst:1

organism-gene


PR:Q9V853 E3 ubiquitin-protein ligase Smurf1 (fruit fly)
fly-SMURF1

sequence


PR:000000466 E3 ubiquitin-protein ligase SMURF1 isoform Short
SMURF1/iso:Short

organism-sequence


PR:Q9CUN6-1 E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)
mSMURF1/iso:Short
Yes
organism-sequence


PR:Q9HCE7-2 E3 ubiquitin-protein ligase SMURF1 isoform Short (human)
hSMURF1/iso:Short
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006511 ubiquitin-dependent protein catabolic processPR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
GO:0030514 negative regulation of BMP signaling pathwayPR:Q9CUN6 mSMURF1 PMID:14711801
PR:Q9HCE7 hSMURF1 PMID:10458166
GO:0036211 protein modification processPR:Q9HCE7-2 hSMURF1/iso:Short PMID:10458166

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004842 ubiquitin-protein transferase activityPR:Q9HCE7-2 hSMURF1/iso:Short PMID:10458166
GO:0005515 protein bindingPR:Q9HCE7-2 hSMURF1/iso:Short PMID:11278251; PMID:16299379

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005622 intracellular anatomical structurePR:Q9CUN6-1 mSMURF1/iso:Short PMID:14711801
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:10458166