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Protein Ontology report - lefty 1
PR:000000287 - http://purl.obolibrary.org/obo/PR_000000287
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000287   
  PRO namelefty 1 
  Synonyms
PRO-Short-label: EXACT:LEFTY1
Gene-based: RELATED:LEFTB | LEFTYB | UNQ278/PRO317
Other: EXACT:protein lefty-1 | stimulated by retinoic acid gene 3 protein
RELATED:Ebaf | left-right determination factor B | Lefty | protein lefty-B | Stra3 | TGF-beta-4 | Tgfb4 | transforming growth factor beta-4
  Definition"A lefty protein that is a translation product of the human LEFTY1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000102 lefty protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 1                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000287 lefty 1
LEFTY1

organism-gene


PR:O75610 left-right determination factor 1 (human)
hLEFTY1

organism-sequence


PR:O75610-1 left-right determination factor 1 isoform 1 (human)
hLEFTY1/iso:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
organism-modification


PR:000077301 left-right determination factor 1 phosphorylated 1 (human)
hLEFTY1/Phos:1

sequence


PR:000000450 lefty 1 isoform 1
LEFTY1/iso:1

organism-sequence


PR:O75610-1 left-right determination factor 1 isoform 1 (human)
hLEFTY1/iso:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
organism-sequence


PR:Q64280-1 left-right determination factor 1 isoform 1 (mouse)
mLEFTY1/iso:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse)
mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000643 lefty 1 isoform 1 cleaved 1
LEFTY1/iso:1/Clv:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse)
mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000644 lefty 1 isoform 1 cleaved 2
LEFTY1/iso:1/Clv:2

organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
modification


PR:000025431 lefty 1 proteolytic cleavage product
LEFTY1/ClvPrd

modification


PR:000000643 lefty 1 isoform 1 cleaved 1
LEFTY1/iso:1/Clv:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse)
mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000644 lefty 1 isoform 1 cleaved 2
LEFTY1/iso:1/Clv:2

organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0008285 negative regulation of cell population proliferationPR:000036547 mLEFTY1/iso:1/Clv:1 PMID:15004567
PR:Q64280-1 mLEFTY1/iso:1 PMID:15004567
GO:0009948 anterior/posterior axis specificationPR:000036547 mLEFTY1/iso:1/Clv:1 PMID:15004567
PR:Q64280-1 mLEFTY1/iso:1 PMID:15004567
GO:0043406 positive regulation of MAP kinase activityPR:000036548 hLEFTY1/iso:1/Clv:2 PMID:11278322

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036546 hLEFTY1/iso:1/Clv:1 PMID:11278322
PR:000036547 mLEFTY1/iso:1/Clv:1 PMID:18039650
PR:000036548 hLEFTY1/iso:1/Clv:2 PMID:11278322