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Protein Ontology report - GTP-binding protein RhoA
PR:000000176 - http://purl.obolibrary.org/obo/PR_000000176
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000176   
  PRO nameGTP-binding protein RhoA 
  Synonyms
PRO-Short-label: EXACT:RHOA
Gene-based: RELATED:ARH12 | ARHA | Arha2 | RHO12
Other: EXACT:h12 | rho cDNA clone 12
  Definition"A Rho-related small GTPase that is a translation product of the human RHOA gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000122 Rho-related small GTPase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 8                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000176

GTP-binding protein RhoA

RHOA


"A Rho-related small GTPase that is a translation product of the human RHOA gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P06780

GTP-binding protein RHO1 (yeast)

yRHOA


"A GTP-binding protein RhoA that is encoded in the genome of yeast." [OMA:P06780, PRO:DNx]


organism-gene



PR:P48148

Ras-like GTP-binding protein Rho1 (fruit fly)

fly-RHOA


"A GTP-binding protein RhoA that is encoded in the genome of fruit fly." [PRO:CNA]


organism-gene



PR:P61585

transforming protein RhoA (cow)

cow-RHOA


"A GTP-binding protein RhoA that is encoded in the genome of cow." [OMA:P61585, PRO:DAN]


organism-sequence



PR:P61585-1

transforming protein RhoA isoform 1 (cow)

cow-RHOA/iso:1


"A GTP-binding protein RhoA isoform 1 that is encoded in the genome of cow." [PRO:DAN]


organism-modification



PR:000036521

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 (cow)

cow-RHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 in cow. UniProtKB:P61585-1, 1-190, Cys-190, MOD:01119." [PMID:1903193, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:P61586

transforming protein RhoA (human)

hRHOA


"A GTP-binding protein RhoA that is encoded in the genome of human." [PRO:CNA, UniProtKB:P61586]


organism-sequence



PR:P61586-1

transforming protein RhoA isoform 1 (human)

hRHOA/iso:1


"A GTP-binding protein RhoA isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036520

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 (human)

hRHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 in human. UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119." [PMID:1383236, PMID:16773203, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000077673

transforming protein RhoA, mature form (human)

hRHOA/mature


"A transforming protein RhoA (human) that has had the propeptide removed. UniProtKB:P61586, 1-190." [PRO:DNx, Reactome:R-HSA-194510, Reactome:R-HSA-194866, Reactome:R-HSA-2134503, Reactome:R-HSA-5672082, Reactome:R-HSA-6804971, Reactome:R-HSA-6804980]


organism-modification



PR:000036520

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 (human)

hRHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 in human. UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119." [PMID:1383236, PMID:16773203, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000084770

transforming protein RhoA cysteinylated 1 (human)

hRHOA/Cyst:1


"A transforming protein RhoA (human) that has been cysteinylated on the residue at the position equivalent to Cys-159 of the amino acid sequence represented by UniProtKB:P61586. UniProtKB:P61586, Cys-159, MOD:00765." [IEDB_epitope:2124861, PRO:DNx]


organism-gene



PR:P61589

transforming protein RhoA (rat)

rRHOA


"A GTP-binding protein RhoA that is encoded in the genome of rat." [OMA:P61589, PRO:DNx]


organism-gene



PR:Q22038

Ras-like GTP-binding protein rhoA (worm)

RHOA (worm)


"A GTP-binding protein RhoA that is encoded in the genome of worm." [OMA:Q22038, PRO:DNx]


organism-gene



PR:Q7T2E8

Rho-related GTP-binding protein RhoA-C (zebrafish)

z-RHOA


"A GTP-binding protein RhoA that is encoded in the genome of zebrafish." [PRO:CNA]


organism-gene



PR:Q9QUI0

transforming protein RhoA (mouse)

mRHOA


"A GTP-binding protein RhoA that is encoded in the genome of mouse." [OMA:Q9QUI0, PRO:DNx]


organism-sequence



PR:Q9QUI0-1

transforming protein RhoA isoform 1 (mouse)

mRHOA/iso:1


"A GTP-binding protein RhoA isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000395

GTP-binding protein RhoA isoform 1

RHOA/iso:1


"A GTP-binding protein RhoA that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61586-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P61585-1

transforming protein RhoA isoform 1 (cow)

cow-RHOA/iso:1


"A GTP-binding protein RhoA isoform 1 that is encoded in the genome of cow." [PRO:DAN]


organism-modification



PR:000036521

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 (cow)

cow-RHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 in cow. UniProtKB:P61585-1, 1-190, Cys-190, MOD:01119." [PMID:1903193, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P61586-1

transforming protein RhoA isoform 1 (human)

hRHOA/iso:1


"A GTP-binding protein RhoA isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036520

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 (human)

hRHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 in human. UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119." [PMID:1383236, PMID:16773203, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q9QUI0-1

transforming protein RhoA isoform 1 (mouse)

mRHOA/iso:1


"A GTP-binding protein RhoA isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000615

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1

RHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 that has been geranylgeranylated on the Cys residue within the C-terminal CaaX motif (a=an aliphatic residue, X=any residue), followed by cleavage of aaX and methylation of the Cys. Example: UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119." [PMID:16773203, PMID:1905729, PRO:CNA]


organism-modification



PR:000036520

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 (human)

hRHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 in human. UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119." [PMID:1383236, PMID:16773203, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036521

GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 (cow)

cow-RHOA/iso:1/IpCysEst:1


"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester-containing 1 in cow. UniProtKB:P61585-1, 1-190, Cys-190, MOD:01119." [PMID:1903193, PRO:CNA, PRO:DAN]

Yes

modification



PR:000018289

GTP-binding protein RhoA proteolytic cleavage product

RHOA/ClvPrd


"A GTP-binding protein RhoA that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036520 hRHOA/iso:1/IpCysEst:1
UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119
acts_upstream_of_or_withinGO:0030036 actin cytoskeleton organization PMID:16773203
GO:0043123 positive regulation of canonical NF-kappaB signal transduction PMID:12761501
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction PMID:12761501
located_inGO:0005886 plasma membrane PMID:16773203
PR:000036521 cow-RHOA/iso:1/IpCysEst:1
UniProtKB:P61585-1, 1-190, Cys-190, MOD:01119
located_inGO:0005886 plasma membrane PMID:1903193