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Protein Ontology report - tumor necrosis factor
PR:000000134 - http://purl.obolibrary.org/obo/PR_000000134
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000134   
  PRO nametumor necrosis factor 
  Synonyms
PRO-Short-label: EXACT:TNF
Gene-based: RELATED:TNFA | TNFSF2
Other: EXACT:cachectin | TNF-a | TNF-alpha | TNFa | tumor necrosis factor alpha | tumor necrosis factor ligand superfamily member 2
  Definition"A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells." [PMID:11053079, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000033 tumor necrosis factor, TNF-like
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification7                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500467
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000134 tumor necrosis factor
TNF

organism-gene


PR:P01375 tumor necrosis factor (human)
hTNF

Yes
organism-sequence


PR:P01375-1 tumor necrosis factor isoform 1 (human)
hTNF/iso:1
Yes
organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
organism-modification


PR:000051774 tumor necrosis factor O-glycosylated 1 (human)
hTNF/OGlyco:1

organism-modification


PR:000051775 tumor necrosis factor O-glycosylated 2 (human)
hTNF/OGlyco:2

organism-gene


PR:P06804 tumor necrosis factor (mouse)
mTNF

organism-sequence


PR:P06804-1 tumor necrosis factor isoform 1 (mouse)
mTNF/iso:1

organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
organism-gene


PR:P16599 tumor necrosis factor (rat)
rTNF

sequence


PR:000000381 tumor necrosis factor isoform 1
TNF/iso:1

organism-sequence


PR:P01375-1 tumor necrosis factor isoform 1 (human)
hTNF/iso:1
Yes
organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
organism-sequence


PR:P06804-1 tumor necrosis factor isoform 1 (mouse)
mTNF/iso:1

organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
modification


PR:000000496 tumor necrosis factor isoform 1 myristoylated form
TNF/iso:1/MyrRes+

modification


PR:000000606 tumor necrosis factor isoform 1 myristoylated 1
TNF/iso:1/Myr:1

organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
modification


PR:000000497 tumor necrosis factor isoform 1 phosphorylated form
TNF/iso:1/PhosRes+

modification


PR:000000607 tumor necrosis factor isoform 1 phosphorylated 1
TNF/iso:1/Phos:1

organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
modification


PR:000000604 tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1

organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
modification


PR:000000605 tumor necrosis factor isoform 1 cleaved 2
TNF/iso:1/Clv:2

organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
modification


PR:000018285 tumor necrosis factor proteolytic cleavage product
TNF/ClvPrd

modification


PR:000000604 tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1

organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
modification


PR:000000605 tumor necrosis factor isoform 1 cleaved 2
TNF/iso:1/Clv:2

organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
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TNF forms found in complexes   

TNF Component
 Complexes
PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000036505 mTNF/iso:1/Clv:1 PMID:9305915
GO:0006915 apoptotic processPR:000036504 hTNF/iso:1/Clv:1 PMID:3856324
PR:P01375-1 hTNF/iso:1 PMID:3856324

Molecular Function GO Term
Protein Forms & Complexes
Evidence
NOT GO:0005125 cytokine activityPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005164 tumor necrosis factor receptor bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
GO:0042802 identical protein bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005576 extracellular regionPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005615 extracellular spacePR:000036505 mTNF/iso:1/Clv:1 PMID:10089307
GO:0005886 plasma membranePR:P01375-1 hTNF/iso:1 PMID:3349526
GO:0016020 membranePR:000036507 hTNF/iso:1/Myr:1 PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1 PMID:10205166