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Protein Ontology report - thrombospondin-2

PR:000000130 - http://purl.obolibrary.org/obo/PR_000000130

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000130

PRO name

thrombospondin-2

Synonyms

PRO-Short-label:	EXACT:	THBS2
Gene-based:	RELATED:	TSP2

Definition

"A thrombospondin subgroup A that is a translation product of the human THBS2 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000029 thrombospondin subgroup A

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	3
Sequence	1	Organism-Sequence	2
Modification	4	Organism-Modification	9

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000130 thrombospondin-2

THBS2

organism-gene

PR:P35440 thrombospondin-2 (chicken)

chick-THBS2

organism-gene

PR:P35442 thrombospondin-2 (human)

hTHBS2

organism-sequence

PR:P35442-1 thrombospondin-2 isoform 1 (human)

hTHBS2/iso:1

organism-modification

PR:000036491 thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-

Yes

organism-modification

PR:000044787 thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2

Yes

organism-modification

PR:000044788 thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3

Yes

organism-modification

PR:000063790 thrombospondin-2, signal peptide removed fucosylserine form (human)

hTHBS2/SigPep-/FucSer+

organism-modification

PR:000064692 thrombospondin-2, signal peptide removed O-glycosylserine form (human)

hTHBS2/SigPep-/OGlycoSer+

organism-modification

PR:000063790 thrombospondin-2, signal peptide removed fucosylserine form (human)

hTHBS2/SigPep-/FucSer+

organism-modification

PR:000071125 thrombospondin-2 deaminated 1 (human)

hTHBS2/Deam:1

organism-modification

PR:000085983 thrombospondin-2, signal peptide removed form (human)

hTHBS2/SigPep-

organism-modification

PR:000036491 thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-

Yes

organism-modification

PR:000064692 thrombospondin-2, signal peptide removed O-glycosylserine form (human)

hTHBS2/SigPep-/OGlycoSer+

organism-modification

PR:000063790 thrombospondin-2, signal peptide removed fucosylserine form (human)

hTHBS2/SigPep-/FucSer+

organism-gene

PR:Q03350 thrombospondin-2 (mouse)

mTHBS2

organism-sequence

PR:Q03350-1 thrombospondin-2 isoform 1 (mouse)

mTHBS2/iso:1

organism-modification

PR:000036492 thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2

organism-modification

PR:000036493 thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3

sequence

PR:000000377 thrombospondin-2 isoform 1

THBS2/iso:1

organism-sequence

PR:P35442-1 thrombospondin-2 isoform 1 (human)

hTHBS2/iso:1

organism-modification

PR:000036491 thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-

Yes

organism-modification

PR:000044787 thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2

Yes

organism-modification

PR:000044788 thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3

Yes

organism-sequence

PR:Q03350-1 thrombospondin-2 isoform 1 (mouse)

mTHBS2/iso:1

organism-modification

PR:000036492 thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2

organism-modification

PR:000036493 thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3

modification

PR:000000591 thrombospondin-2 isoform 1, signal peptide removed form

THBS2/iso:1/SigPep-

organism-modification

PR:000036491 thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-

Yes

modification

PR:000000592 thrombospondin-2 isoform 1 cleaved 2

THBS2/iso:1/Clv:2

organism-modification

PR:000036492 thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2

organism-modification

PR:000044787 thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2

Yes

modification

PR:000000593 thrombospondin-2 isoform 1 cleaved 3

THBS2/iso:1/Clv:3

organism-modification

PR:000036493 thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3

organism-modification

PR:000044788 thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3

Yes

modification

PR:000025438 thrombospondin-2 proteolytic cleavage product

THBS2/ClvPrd

modification

PR:000000592 thrombospondin-2 isoform 1 cleaved 2

THBS2/iso:1/Clv:2

organism-modification

PR:000036492 thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2

organism-modification

PR:000044787 thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2

Yes

modification

PR:000000593 thrombospondin-2 isoform 1 cleaved 3

THBS2/iso:1/Clv:3

organism-modification

PR:000036493 thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3

organism-modification

PR:000044788 thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036491 hTHBS2/iso:1/SigPep- UniProtKB:P35442-1, 19-1172	enables	GO:0008201 heparin binding	PMID:1459996
PR:000044787 hTHBS2/iso:1/Clv:2 UniProtKB:P35442-1, 19-306	acts_upstream_of_or_within	GO:0016525 negative regulation of angiogenesis	PMID:17082774
	acts_upstream_of_or_within	GO:0060055 angiogenesis involved in wound healing	PMID:17082774
	located_in	GO:0005615 extracellular space	PMID:17082774
PR:000044788 hTHBS2/iso:1/Clv:3 UniProtKB:P35442-1, 307-1172	acts_upstream_of_or_within	GO:0016525 negative regulation of angiogenesis	PMID:17082774
	acts_upstream_of_or_within	GO:0060055 angiogenesis involved in wound healing	PMID:17082774