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Protein Ontology report - Rho-associated protein kinase 1
PR:000000120 - http://purl.obolibrary.org/obo/PR_000000120
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000120   
  PRO nameRho-associated protein kinase 1 
  Synonyms
PRO-Short-label: EXACT:ROCK1
Other: EXACT:p160 ROCK-1 | p160ROCK | renal carcinoma antigen NY-REN-35 | rho-associated, coiled-coil-containing protein kinase 1 | Rho-associated, coiled-coil-containing protein kinase I | ROCK-I
  Definition"A Rho-associated protein kinase that is a translation product of the human ROCK1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000024 Rho-associated protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification5                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1503
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000120

Rho-associated protein kinase 1

ROCK1


"A Rho-associated protein kinase that is a translation product of the human ROCK1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P70335

Rho-associated protein kinase 1 (mouse)

mROCK1


"A Rho-associated protein kinase 1 that is encoded in the genome of mouse." [OMA:P70335, PRO:DNx]


organism-sequence



PR:P70335-1

Rho-associated protein kinase 1 isoform 1 (mouse)

mROCK1/iso:1


"A Rho-associated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036476

Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)

mROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in mouse. UniProtKB:P70335-1, 1-1113." [PMID:11283607, PMID:16983089, PRO:CNA]

Yes

organism-sequence



PR:P70335-2

Rho-associated protein kinase 1 isoform m2 (mouse)

mROCK1/iso:m2


"A Rho-associated protein kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70335-2." [PRO:DNx, UniProtKB:P70335]


organism-gene



PR:Q13464

Rho-associated protein kinase 1 (human)

hROCK1


"A Rho-associated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13464]


organism-sequence



PR:Q13464-1

Rho-associated protein kinase 1 isoform 1 (human)

hROCK1/iso:1


"A Rho-associated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026340

Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)

hROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in human. UniProtKB:Q13464-1, 1-1113." [PRO:DNx, UniProtKB:Q13464]

Yes

organism-modification



PR:000044586

Rho-associated protein kinase 1 isoform 1 unmodified form (human)

hROCK1/iso:1/UnMod


"A Rho-associated protein kinase 1 isoform 1 unmodified form in human." [PRO:DNx]

Yes

organism-modification



PR:000061208

Rho-associated protein kinase 1, initiator methionine removed form (human)

hROCK1/InitMet-


"A Rho-associated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:Q13464, 2-1354." [PRO:DNx, Reactome:R-HSA-212509, Reactome:R-HSA-6804967, Reactome:R-HSA-6806527]


organism-modification



PR:000070060

Rho-associated protein kinase 1 deaminated 1 (human)

hROCK1/Deam:1


"A Rho-associated protein kinase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-787 of the amino acid sequence represented by UniProtKB:Q13464. UniProtKB:Q13464, Gln-787, MOD:00685." [IEDB_epitope:1987374, PRO:DNx]


organism-modification



PR:000070524

Rho-associated protein kinase 1 phosphorylated 1 (human)

hROCK1/Phos:1


"A Rho-associated protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-1301 of the amino acid sequence represented by UniProtKB:Q13464. UniProtKB:Q13464, Ser-1301, MOD:00046." [IEDB_epitope:1360482, PRO:DNx]


organism-modification



PR:000082399

Rho-associated protein kinase 1 deaminated 2 (human)

hROCK1/Deam:2


"A Rho-associated protein kinase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-644 of the amino acid sequence represented by UniProtKB:Q13464. UniProtKB:Q13464, Asn-644, MOD:00684." [IEDB_epitope:1981270, PRO:DNx]


organism-gene



PR:Q63644

Rho-associated protein kinase 1 (rat)

rROCK1


"A Rho-associated protein kinase 1 that is encoded in the genome of rat." [OMA:Q63644, PRO:DNx]


organism-sequence



PR:Q63644-1

Rho-associated protein kinase 1 isoform r1 (rat)

rROCK1/iso:r1


"A Rho-associated protein kinase 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63644-1." [PRO:DNx, UniProtKB:Q63644]


organism-sequence



PR:Q63644-2

Rho-associated protein kinase 1 isoform r2 (rat)

rROCK1/iso:r2


"A Rho-associated protein kinase 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63644-2." [PRO:DNx, UniProtKB:Q63644]


sequence



PR:000000307

Rho-associated protein kinase 1 isoform 1

ROCK1/iso:1


"A Rho-associated protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13464-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P70335-1

Rho-associated protein kinase 1 isoform 1 (mouse)

mROCK1/iso:1


"A Rho-associated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036476

Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)

mROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in mouse. UniProtKB:P70335-1, 1-1113." [PMID:11283607, PMID:16983089, PRO:CNA]

Yes

organism-sequence



PR:Q13464-1

Rho-associated protein kinase 1 isoform 1 (human)

hROCK1/iso:1


"A Rho-associated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026340

Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)

hROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in human. UniProtKB:Q13464-1, 1-1113." [PRO:DNx, UniProtKB:Q13464]

Yes

organism-modification



PR:000044586

Rho-associated protein kinase 1 isoform 1 unmodified form (human)

hROCK1/iso:1/UnMod


"A Rho-associated protein kinase 1 isoform 1 unmodified form in human." [PRO:DNx]

Yes

modification



PR:000000563

Rho-associated protein kinase 1 isoform 1 cleaved 1

ROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 that has been processed by caspase-3 downstream the sequence motif DETD, removing the inhibitory C-terminus." [PMID:11283607, PMID:16983089]


organism-modification



PR:000026340

Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)

hROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in human. UniProtKB:Q13464-1, 1-1113." [PRO:DNx, UniProtKB:Q13464]

Yes

organism-modification



PR:000036476

Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)

mROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in mouse. UniProtKB:P70335-1, 1-1113." [PMID:11283607, PMID:16983089, PRO:CNA]

Yes

modification



PR:000002529

Rho-associated protein kinase 1 isoform 1 unmodified form

ROCK1/iso:1/UnMod


"A Rho-associated protein kinase 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


organism-modification



PR:000044586

Rho-associated protein kinase 1 isoform 1 unmodified form (human)

hROCK1/iso:1/UnMod


"A Rho-associated protein kinase 1 isoform 1 unmodified form in human." [PRO:DNx]

Yes

modification



PR:000026574

Rho-associated protein kinase 1 isoform 1, initiator methionine removed form

ROCK1/iso:1/InitMet-


"A Rho-associated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018280

Rho-associated protein kinase 1, initiator methionine removed form

ROCK1/InitMet-


"A Rho-associated protein kinase 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026574

Rho-associated protein kinase 1 isoform 1, initiator methionine removed form

ROCK1/iso:1/InitMet-


"A Rho-associated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000061208

Rho-associated protein kinase 1, initiator methionine removed form (human)

hROCK1/InitMet-


"A Rho-associated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:Q13464, 2-1354." [PRO:DNx, Reactome:R-HSA-212509, Reactome:R-HSA-6804967, Reactome:R-HSA-6806527]


modification



PR:000025435

Rho-associated protein kinase 1 proteolytic cleavage product

ROCK1/ClvPrd


"A Rho-associated protein kinase 1 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000563

Rho-associated protein kinase 1 isoform 1 cleaved 1

ROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 that has been processed by caspase-3 downstream the sequence motif DETD, removing the inhibitory C-terminus." [PMID:11283607, PMID:16983089]


organism-modification



PR:000026340

Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)

hROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in human. UniProtKB:Q13464-1, 1-1113." [PRO:DNx, UniProtKB:Q13464]

Yes

organism-modification



PR:000036476

Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)

mROCK1/iso:1/Clv:1


"A Rho-associated protein kinase 1 isoform 1 cleaved 1 in mouse. UniProtKB:P70335-1, 1-1113." [PMID:11283607, PMID:16983089, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026340 hROCK1/iso:1/Clv:1
UniProtKB:Q13464-1, 1-1113
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:11283607
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002529 ROCK1/iso:1/UnMod PMID:11283607
PR:000036476 mROCK1/iso:1/Clv:1
UniProtKB:P70335-1, 1-1113
acts_upstream_of_or_withinGO:0010659 cardiac muscle cell apoptotic process PMID:16983089
GO:0030036 actin cytoskeleton organization PMID:11283607; PMID:16983089
PR:000044586 hROCK1/iso:1/UnMod enablesGO:0004674 protein serine/threonine kinase activity PMID:15699075
GO:0004674 protein serine/threonine kinase activity PMID:15699075
PR:Q13464-1 hROCK1/iso:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:10436159
GO:0007266 Rho protein signal transduction PMID:8798490
GO:0030036 actin cytoskeleton organization PMID:10436159
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:8798490
GO:0031267 small GTPase binding PMID:14660612; PMID:15475352