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Protein Ontology report - retinoblastoma-like protein 1
PR:000000118 - http://purl.obolibrary.org/obo/PR_000000118
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000118   
  PRO nameretinoblastoma-like protein 1 
  Synonyms
PRO-Short-label: EXACT:RBL1
Other: EXACT:107 kDa retinoblastoma-associated protein | pRb1
  Definition"A retinoblastoma-like protein that is a translation product of the human RBL1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000023 retinoblastoma-like protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence3                                                  Organism-Sequence 4                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000118

retinoblastoma-like protein 1

RBL1


"A retinoblastoma-like protein that is a translation product of the human RBL1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:D3ZS28

retinoblastoma-like protein 1 (rat)

rRBL1


"A retinoblastoma-like protein 1 that is encoded in the genome of rat." [OMA:D3ZS28, PRO:DNx]


organism-gene



PR:P28749

retinoblastoma-like protein 1 (human)

hRBL1


"A retinoblastoma-like protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28749]


organism-sequence



PR:P28749-1

retinoblastoma-like protein 1 isoform 1 (human)

hRBL1/iso:1


"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036470

retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)

hRBL1/iso:1/Phos:1


"A retinoblastoma-like protein 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA]

Yes

organism-sequence



PR:P28749-2

retinoblastoma-like protein 1 isoform 2 (human)

hRBL1/iso:2


"A retinoblastoma-like protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000049024

retinoblastoma-like protein 1 phosphorylated 1 (human)

hRBL1/Phos:1


"A retinoblastoma-like protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-369, and phosphoserine at positions 640, 964 and 975 of the amino acid sequence represented by UniProtKB:P28749. UniProtKB:P28749, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PRO:DNx, Reactome:R-HSA-1226085]


organism-gene



PR:Q24472

retinoblastoma family protein (fruit fly)

fly-RBL1


"A retinoblastoma-like protein 1 that is encoded in the genome of fruit fly." [PRO:CNA]


organism-gene



PR:Q64701

retinoblastoma-like protein 1 (mouse)

mRBL1


"A retinoblastoma-like protein 1 that is encoded in the genome of mouse." [OMA:Q64701, PRO:DNx]


organism-sequence



PR:Q64701-1

retinoblastoma-like protein 1 isoform Long (mouse)

mRBL1/iso:Long


"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q64701-2

retinoblastoma-like protein 1 isoform Short (mouse)

mRBL1/iso:Short


"A retinoblastoma-like protein 1 isoform 3 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000303

retinoblastoma-like protein 1 isoform 1

RBL1/iso:1


"A retinoblastoma-like protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28749-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P28749-1

retinoblastoma-like protein 1 isoform 1 (human)

hRBL1/iso:1


"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036470

retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)

hRBL1/iso:1/Phos:1


"A retinoblastoma-like protein 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA]

Yes

organism-sequence



PR:Q64701-1

retinoblastoma-like protein 1 isoform Long (mouse)

mRBL1/iso:Long


"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000458

retinoblastoma-like protein 1 isoform 1 phosphorylated form

RBL1/iso:1/PhosRes+


"A retinoblastoma-like protein 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000559

retinoblastoma-like protein 1 isoform 1 phosphorylated 1

RBL1/iso:1/Phos:1


"A retinoblastoma-like protein 1 isoform 1 phosphorylated form in which the phosphorylation occurs in an RxL motif-dependent fashion by cyclin Cdk4. Example: UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA, PRO:DAN]


organism-modification



PR:000036470

retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)

hRBL1/iso:1/Phos:1


"A retinoblastoma-like protein 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA]

Yes

sequence



PR:000000304

retinoblastoma-like protein 1 isoform 2

RBL1/iso:2


"A retinoblastoma-like protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28749-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P28749-2

retinoblastoma-like protein 1 isoform 2 (human)

hRBL1/iso:2


"A retinoblastoma-like protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000305

retinoblastoma-like protein 1 isoform 3

RBL1/iso:3


"A retinoblastoma-like protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64701-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q64701-2

retinoblastoma-like protein 1 isoform Short (mouse)

mRBL1/iso:Short


"A retinoblastoma-like protein 1 isoform 3 that is encoded in the genome of mouse." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036470 hRBL1/iso:1/Phos:1
UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046
acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:11884610
enablesGO:0005515 protein binding PMID:11884610
NOT GO:0030308 negative regulation of cell growth PMID:11884610
PR:P28749-1 hRBL1/iso:1 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:8319904
enablesGO:0005515 protein binding PMID:11884610
GO:0030308 negative regulation of cell growth PMID:11884610