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Protein Ontology report - mitogen-activated protein kinase 1
PR:000000103 - http://purl.obolibrary.org/obo/PR_000000103
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000103   
  PRO namemitogen-activated protein kinase 1 
  Synonyms
PRO-Short-label: EXACT:MAPK1
Gene-based: RELATED:ERK2 | Mapk | PRKM1 | PRKM2
Other: EXACT:ERK-2 | ERT1 | extracellular signal-regulated kinase 2 | MAP kinase 1 | MAP kinase 2 | MAP kinase isoform p42 | MAPK 1 | MAPK 2 | mitogen-activated protein kinase 2 | p42-MAPK
  Definition"A mitogen-activated protein kinase that is a translation product of the human MAPK1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000019 mitogen-activated protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification6                                                  Organism-Modification 19                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1495
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000103 mitogen-activated protein kinase 1
MAPK1

organism-gene


PR:P28482 mitogen-activated protein kinase 1 (human)
hMAPK1

organism-sequence


PR:P28482-1 mitogen-activated protein kinase 1 isoform 1 (human)
hMAPK1/iso:1
Yes
organism-modification


PR:000026341 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
hMAPK1/iso:1/Phos:1
Yes
organism-sequence


PR:P28482-2 mitogen-activated protein kinase 1 isoform h2 (human)
hMAPK1/iso:h2

organism-modification


PR:000045734 mitogen-activated protein kinase 1 phosphorylated 1 (human)
hMAPK1/Phos:1

organism-modification


PR:000048313 mitogen-activated protein kinase 1, initiator methionine removed form (human)
hMAPK1/InitMet-

organism-modification


PR:000048314 mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)
hMAPK1/InitMet-/Phos:1

organism-modification


PR:000060366 mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321V/InitMet-/Phos:1

organism-modification


PR:000060482 mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322K/InitMet-/Phos:1

organism-modification


PR:000061403 mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58G/InitMet-/Phos:1

organism-modification


PR:000061840 mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E81K/InitMet-/Phos:1

organism-modification


PR:000062009 mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322V/InitMet-/Phos:1

organism-modification


PR:000062395 mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human)
hMAPK1/InitMet-/Phos:2

organism-modification


PR:000062794 mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321N/InitMet-/Phos:1

organism-modification


PR:000062965 mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58L/InitMet-/Phos:1

organism-modification


PR:000063285 mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:S142L/InitMet-/Phos:1

organism-modification


PR:000063321 mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322A/InitMet-/Phos:1

organism-modification


PR:000083225 mitogen-activated protein kinase 1 cysteinylated 1 (human)
hMAPK1/Cyst:1

organism-modification


PR:000083581 mitogen-activated protein kinase 1 methylated 1 (human)
hMAPK1/Me:1

organism-modification


PR:000084106 mitogen-activated protein kinase 1 methylated 2 (human)
hMAPK1/Me:2

organism-gene


PR:P39745 mitogen-activated protein kinase mpk-1 (worm)
MAPK1 (worm)

organism-sequence


PR:P39745-1 mitogen-activated protein kinase mpk-1 isoform b (worm)
MAPK1/iso:b (worm)

organism-sequence


PR:P39745-2 mitogen-activated protein kinase mpk-1 isoform a (worm)
MAPK1/iso:a (worm)

organism-gene


PR:P42525 extracellular signal-regulated kinase 1 (Dictyostelium discoideum)
Dicty-MAPK1

organism-gene


PR:P63085 mitogen-activated protein kinase 1 (mouse)
mMAPK1

organism-sequence


PR:P63085-1 mitogen-activated protein kinase 1 isoform 1 (mouse)
mMAPK1/iso:1
Yes
organism-modification


PR:000036464 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)
mMAPK1/iso:1/Phos:1
Yes
organism-gene


PR:P63086 mitogen-activated protein kinase 1 (rat)
rMAPK1

organism-modification


PR:000036466 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat)
rMAPK1/iso:1/Phos:1
Yes
sequence


PR:000000289 mitogen-activated protein kinase 1 isoform 1
MAPK1/iso:1

organism-sequence


PR:P28482-1 mitogen-activated protein kinase 1 isoform 1 (human)
hMAPK1/iso:1
Yes
organism-modification


PR:000026341 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
hMAPK1/iso:1/Phos:1
Yes
organism-sequence


PR:P63085-1 mitogen-activated protein kinase 1 isoform 1 (mouse)
mMAPK1/iso:1
Yes
organism-modification


PR:000036464 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)
mMAPK1/iso:1/Phos:1
Yes
modification


PR:000000454 mitogen-activated protein kinase 1 isoform 1 phosphorylated form
MAPK1/iso:1/PhosRes+

modification


PR:000000556 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1
MAPK1/iso:1/Phos:1

organism-modification


PR:000026341 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
hMAPK1/iso:1/Phos:1
Yes
organism-modification


PR:000036464 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)
mMAPK1/iso:1/Phos:1
Yes
organism-modification


PR:000036466 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat)
rMAPK1/iso:1/Phos:1
Yes
modification


PR:000025465 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form
MAPK1/iso:1/InitMet-

modification


PR:000000453 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form
MAPK1/iso:1/InitMet-/AcRes+

modification


PR:000018278 mitogen-activated protein kinase 1, initiator methionine removed form
MAPK1/InitMet-

modification


PR:000025465 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form
MAPK1/iso:1/InitMet-

modification


PR:000000453 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form
MAPK1/iso:1/InitMet-/AcRes+

organism-modification


PR:000048313 mitogen-activated protein kinase 1, initiator methionine removed form (human)
hMAPK1/InitMet-

organism-modification


PR:000048314 mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)
hMAPK1/InitMet-/Phos:1

organism-modification


PR:000060366 mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321V/InitMet-/Phos:1

organism-modification


PR:000060482 mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322K/InitMet-/Phos:1

organism-modification


PR:000061403 mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58G/InitMet-/Phos:1

organism-modification


PR:000061840 mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E81K/InitMet-/Phos:1

organism-modification


PR:000062009 mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322V/InitMet-/Phos:1

organism-modification


PR:000062395 mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human)
hMAPK1/InitMet-/Phos:2

organism-modification


PR:000062794 mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321N/InitMet-/Phos:1

organism-modification


PR:000062965 mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58L/InitMet-/Phos:1

organism-modification


PR:000063285 mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:S142L/InitMet-/Phos:1

organism-modification


PR:000063321 mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322A/InitMet-/Phos:1

modification


PR:000025458 mitogen-activated protein kinase 1 proteolytic cleavage product
MAPK1/ClvPrd

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0000165 MAPK cascadePR:000036464 mMAPK1/iso:1/Phos:1 PMID:8626447
GO:0006468 protein phosphorylationPR:000036464 mMAPK1/iso:1/Phos:1 PMID:15284227
GO:0006915 apoptotic processPR:000026341 hMAPK1/iso:1/Phos:1 PMID:10958679
GO:0006935 chemotaxisPR:000026341 hMAPK1/iso:1/Phos:1 PMID:10706854
PR:P28482-1 hMAPK1/iso:1 PMID:10706854
GO:0006950 response to stressPR:P28482-1 hMAPK1/iso:1 PMID:10958679
GO:0007165 signal transductionPR:000026341 hMAPK1/iso:1/Phos:1 PMID:1540184
PR:000036464 mMAPK1/iso:1/Phos:1 PMID:11684667
GO:0007268 chemical synaptic transmissionPR:P28482-1 hMAPK1/iso:1 PMID:10706854

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004672 protein kinase activityPR:000026341 hMAPK1/iso:1/Phos:1 PMID:10706854
PR:000036464 mMAPK1/iso:1/Phos:1 PMID:14744933
GO:0004707 MAP kinase activityPR:000026341 hMAPK1/iso:1/Phos:1 PMID:10706854
PR:000036464 mMAPK1/iso:1/Phos:1 PMID:11684667; PMID:12223545; PMID:15314156; PMID:8626447
NOT GO:0004707 MAP kinase activityPR:P28482-1 hMAPK1/iso:1 PMID:10706854
GO:0005515 protein bindingPR:000026341 hMAPK1/iso:1/Phos:1 PMID:16291755
GO:0042803 protein homodimerization activityPR:000036466 rMAPK1/iso:1/Phos:1 PMID:9604935

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000036464 mMAPK1/iso:1/Phos:1 PMID:11726647; PMID:12925581; PMID:16251435
GO:0005737 cytoplasmPR:P63085-1 mMAPK1/iso:1 PMID:11726647; PMID:12223545